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Vol 5 Issue 2                                                                                                                                                  Subscribe
In This Issue:

This issue will focus on “Mastering the Challenges of Air-Sensitive Slurries.”     

Welcome to A&SoF. A&SoF is an e-newsletter, managed by BHS, with its sole purpose to enhance the filtration knowledge of the marketplace to solve actual plant problems.   

The focus of this issue is “Mastering the Challenges of Air-Sensitive Slurries.”  

In a recent article in Chemical Engineering, Joy LePree writes that “air sensitive materials, such as OLED applications, lithium-ion batteries and other chemical and pharmaceutical processes, create an abundance of challenges for tightly controlled atmospheres as well as for available filtration technologies.”


Following this abstract is a technical article by BHS “THIN-CAKE FILTRATION TECHNOLOGY TO MEET FULL CONTAINMENT FOR AIR-SENSITIVE AND TOXIC CHEMICAL & PHARMACEUTICAL PRODUCTION.”  The article is summarized below.    

Finally, BHS and A&SoF are growing again!  We are pleased to announce that Garrett Bergquist has joined us as a “Lab and Pilot Filtration Testing Engineer”.  Garrett will expand our testing capabilities as well as oversee the opening of our new filtration lab.  Please contact Garrett with your ideas.  This will be an important benefit to current and future BHS clients.    

I hope that you find A&SoF useful and informative. Your comments, ideas and suggestions for future issues are much appreciated. You can now follow A&SoF on Facebook Facebook; please visit our page and soon on our "blog." If you missed any of the issues, please click on the following link: A&SoF, to view them. We look forward to your continued input and wish all of our readers a successful and healthy 2014.

Barry A. Perlmutter - barry.perlmutter@bhs-filtration.com 


Featured Problem Solving Technical Articles
 

Chemical Engineering:  
“Mastering the Challenges of Air-Sensitive Slurries.”


Joy LePree, Chemical Engineering Magazine, www.che.com, April 2014, pages 24 – 27. 

In this article, Joy discusses the techniques for maintaining inert and controlled atmospheres.  She then continues by examining the use of glove boxes / glove bags for filtration and drying, product unloading, transfer and handling.  Joy summarizes by saying that new technologies are making it easier to master the tricky challenges for these materials.     

BHS ARTICLE:  
“THIN-CAKE FILTRATION TECHNOLOGY TO MEET FULL CONTAINMENT FOR AIR-SENSITIVE AND TOXIC CHEMICAL & PHARMACEUTICAL PRODUCTION.” 

ABSTRACT & INTRODUCTION
In many chemical and pharmaceutical processes, solid-liquid separation, cake washing and drying steps directly impact the effectiveness of the production operation.  Further complicating these operations is the nature of the process and especially if the process is air-sensitive or toxic.  

This article discusses the choice of thin-cake (2 – 25 mm) pressure separation technology for full containment, no residual heel and the benefits of optimizing the effectiveness of the production process.  For full containment, the paper then continues with a discussion of clean-in-place operations to meet current Good Manufacturing Practices (cGMP) guidelines including riboflavin tests and validations.  ANSI/ISA S88 batch process control system standards are also examined.  Finally, factory and site acceptance testing is described.

The Autopress AP Pressure Filter technology is able to conduct filtration, cake washing, pressure and vacuum drying all in a contained environment.  Cake discharge is complete and there in no residual liquid or solid heel.  This is an important benefit for air-sensitive and toxic products.    

The materials of construction provide for all product wetted parts to be polished stainless steel or alloys with rounded corners to eliminate product holdup.  The filter media can be metallic, synthetic or sintered stainless steel that is welded to the filter plates. All process and mechanical operations are either pneumatic or electric which allowed for a clean installation.  
The PLC controls and including the functional specification, Factory Acceptance Test (FAT) and Site Acceptance Test (SAT) all comply with Good Automated Manufacturing Practices (GAMP) guidelines.  Finally, as part of the FAT and SAT, a Riboflavin CIP test is conducted to demonstrate the ability of the AP Filter to be cleaned for batch-to-batch integrity or product-to-product campaigns. Read More and Download the full article 

C³ - Customer Contribution Corner
 
 
 
BHS-Filtration Inc. News & Updates:

Welcome Garrett Bergquist, BHS Lab & Pilot Filtration Testing Engineer    
Garrett joins BHS with experience as a process engineer from Celgard, a global leader in the development and production of specialty microporous membranes and products for the lithium battery separator industry. He has a BS degree in Chemical Engineering from the University of South Carolina.  You can reach Garrett at garrett.bergquist@bhs-filtration.com.   


 
Upcoming BHS Presentations:

2014 AIChE Process Development Symposium in Philadelphia, PA.  

BHS presentation “Continuous Pressure and Vacuum Filtration Technologies as Alternatives to Batch Filtration Operations.

2014 GPA (Gas Processors Association) Europe Annual Conference, Madrid 17 - 19 September 2014, Spain.

BHS Presentation “Removing Divalent Salts from MEG Reclamation Units - Developing a Tailor Made Solution

 


For Our Existing Clients- Please Remember to Contact BHS for Your On-Site Service

"Lunch & Learn Filtration Seminars"; BHS is organizing technical seminars focusing on the principles of filtration with application specific information. Contact BHS for details and scheduling.