The bad news - or not?
The Dry Eye Assessment and Management (DREAM) study is the first large scale (n=535), randomised clinical trial to look into long term (12 months) efficacy and safety of omega-3 in relieving symptoms (using the Ocular Surface Discomfort Index or OSDI) and signs (conjunctival and corneal staining, BUT and Schirmer's) of dry eye disease. Daily doses of either 2000 mg of EPA plus 1000mg of DHA versus a placebo of olive oil flavoured with fish concentrate, found that both groups improved, with no significant difference between the groups. Before you stop recommending supplements,
- Is olive oil really a placebo when it is known to have anti inflammatory properties?
- What kind of omega-3 was used? Remember the controvery about re-esterified or not? So which is this?