DxF Newsletter  Vol 1 Num 7.

Welcome to the DxF Newsletter!
We are commited to promoting holistic causal diagnosis for everyone to understand the underlying cause of a condition.

Investigating Causes, Providing Choices

This week we conclude our series on inflammation as a causal factor for depression in the body domain.  The information has been very detailed to give you an idea of how the body functions. However, here are the diagnostic tests we have discussed that will determine causal factors of inflammation:

For Allergies:
IgE, Vitamin A, Amino Acid Profile, Stool Analysis

For Chemical Sensitivities:
IgG, Elimination Diets, Quick Environmental Exposure Sensitivity Indicator, Liver & Kidney Function tests, Intestinal Inflammation Imaging

This week’s Inflammation Regulation:
Serum Amino Acids, Omega 3 & 6 Fatty Acids blood test and Minerals blood or hair analysis, Cortisone & ‘Adrenaline’ tests

A medical history and physical exam findings will give you more clues to help you choose the most fruitful laboratory tests. Contact the DxF for information about  health care providers who would be knowledgeable in this field of diagnosis.


Week 7 – Depression / Body
Nerve Inflammation – Part 3 of 3

Part 1 – Allergies
Part 2 – Food & Chemical Sensitivities
Part 3 - Inflammation Regulators
Over the past 2 weeks, we continued our review of potential causes of clinical depression in the body domain by addressing inflammations that are caused by allergies, food & chemical sensitivities. This week, we’ll continue with inflammation causes of depression in part 3 of 3: Inflammation - Regulation.
With allergies and sensitivities, the site of initiating the inflammation frequently starts in the skin, the respiratory, or gastro-intestinal tracts when an offending protein or chemical gets through the body’s initial barrier.  Histamine and other pro-inflammatory chemicals are released at the site of entry of the offending agent to cause a local inflammation by dilating arteries which allows chemicals and cells to leak out of the circulatory system at an accelerated rate.  The leakage of fluids out of the blood vessels is a normal part of the body’s defense system to dilute, contain and destroy offending agents.
If too much of the offending agents get through the body’s barriers or there is an overreaction of histamine release, or the inflammation is not regulated properly, the inflammation may spread to distant sites in the body including the brain.  When portions of the brain become inflamed, nerves do not function properly.  Depending on the degree of severity, they may fire too rapidly, repetitively, or conversely too slow and infrequently.  Depending on which nerves are inflamed will determine which emotions, cognitive or motor functions behave abnormally.  If some degree of inflammation is already present in the parts of the brain responsible for initiating or inhibiting depression, symptoms may be produced during episodes when inflammation is exacerbated.
Part 3 – Regulating Inflammation
What Are Chemical Messengers?
Once the inflammation process has begun, it must be regulated to control the degree, location and duration of inflammation.  This is accomplished by a wide range of different chemical messengers that together regulate different portions of the inflammation process.
Effects of Chemical Messengers Hi Honey<3
Some chemical messengers increase inflammation.  Others will decrease it.  The chemical messengers that have the most notable direct effects on inflammation regulation are: cortisone, ‘adrenalin’, the omega 3 & 6 eicosanoids as well as VIP and PACAP.  Many of the other chemical messengers have indirect or less pronounced effects on inflammation regulation.
If the chemical messengers are being produced in either too high or too low a quantity, there is a possibility for the inflammatory response to be excessive, too prolonged or too widespread.  
What Causes An Excess or Deficiency of Chemical Messengers
  • Insufficient Raw Materials - A major factor that leads to insufficient production of the inflammation chemical messengers is when there is a deficiency of the nutrients that make up the messengers.   An excess of the chemical messenger can be produced when there is too much of the raw materials present.  For example, too little omega 3 fatty acids (fish, grass fed cows, free range chicken eggs) will lead to a deficiency to the omega 3 based regulators that decrease inflammation.  Too much omega 6 fatty acids (canola, corn and safflower oils, eggs & beef from feed lots) will lead to an excess of the pro-inflammatory messengers.
  • Organ or Tissue Functional ‘Weakness’ at the Chemical Messenger Production Site - Alterations in any of the organs or tissues that influence the production or release of these inflammatory regulators.  For example, adrenal gland stress (i.e. caffeine, too little sleep, skipped meals, stress, altered nerve or vascular supply) can cause a localized inflammation in the adrenal gland which can impair blood flow to the glands.  This reduced blood flow can reduce the rate of production or release of the inflammatory regulatory chemical cortisone.   The insufficient cortisone release will then exacerbate inflammation throughout the body.

Words of The Week

Hormones, Cytokines & Eicosanoids

These terms refer to three overlapping classes of chemical messengers in the body.  There are many different chemicals in each of these classes and each chemical performs different functions.  Many of these chemicals can regulate inflammation, causing different parts of the inflammation process to either increase or decrease.

They are all secreted directly into either the tissue surrounding the cell where they are manufactured, into the blood or even within their own cell.  These three classes of chemical messengers may be identified by the types of chemicals they are and where they are produced.

Hormones – The features of this group of chemical messengers are:
Production sites – each hormone is produced by a specific set of cells in a specific organ and; has their effect on distant cells.  
Chemical Class - hormones have the widest range of compositions.  They may be
  1. Amino acid based
    1. Proteins (long chains of amino acids) - insulin
    2. Peptides (short chains of amino acids) – growth hormone, thyroid stimulating hormone, adrenocorticotropic hormone (ACTH), etc.
    3. Mono-amines (single amino acid based chemicals) – thyroxin, ‘adrenalin’, serotonin, dopamine, etc.
  2. Lipids (fats & oils) – These are hormones manufactured from cholesterol: cortisone, estrogen, progesterone, testosterone, etc.


Words cont.

Cytokines – The features of this group of chemical messengers are:
Production sites - They are produced by a wide range of cells throughout the body.  
Chemical Class – cytokines are proteins.
Examples of cytokines includes: interferon and interleukins.

Eicosanoids – The features of this group of chemical messengers are:  
Production sites - They are produced by a wide range of cells throughout the body.  
Chemical Class – eicosanoids are derived from fatty acids, commonly omega 3 (usually anti-inflammitory) and omega 6 (usually pro-inflammitory).  Eicosanoids fall into 4 families: prostaglandins; prostacyclins; thromboxanes and leukotrienes.

In addition, eicosanoids are notable that they also typically exert their effect for a very short time period compared to many of the hormones and cytokines.
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Diagnostic Testing
Hormones – There are blood or urine tests for ‘adrenalin’ and thyroxin although particular care must be taken regarding the extremely high false negative rates for thyroxin.  That hormone may need additional diagnosis through evaluation of Thyroid Stimulating Hormone (TSH), the ingredients of thyroxin (tyrosine & iodine) or other methods.
Cytokines – cortisone breakdown products may be evaluated in the urine.  The estrogens, progesterones and testosterones may be evaluated although they generally do not have as pronounced effect on inflammation regulation as cortisone.
Eicosanoids – There are a wide range of eicosanoids that may be involved.  A good screening tool is to evaluate the omega 3 and omega 6 fatty acids in the blood and follow up from there if the ratio between the two is inappropriate.
The range of nutrients to test why any given hormone, cytokine, or eicosanoids are inappropriate is extensive but a good starting point is to consider a screening test for serum amino acids, the omega 3 & 6 fatty acids and minerals.

Inflammation may be caused by mechanisms in addition to allergies, chemical & food sensitivities or inadequate resolution.  It may also be caused by any type of trauma (physical, chemical, thermal, electrical, etc.) or infection.  Traumas and infections may also result in inflammations distant from the primary site including the brain where it may cause or contribute to depression.  
These types of inflammation triggers and wide spectrum reactions are typically easy for the patient to associate and need little diagnostic follow up if the symptoms resolve with resolution of the infection or trauma.  When symptoms persist after the trauma or infection are healed, then it may be appropriate to consider diagnosing why there are aftereffects, including consideration that inflammation regulation nutrients and organs have been stressed to the point of becoming symptomatic.

Important Note:

The information in this newsletter is not intended to replace the services of trained health professionals. You are advised to consult with your health care professional with regard to matters relating to diagnosising and treating your health, and in particular regarding symptoms that may require immediate attention. If you suspect that you have a medical problem, please seek competent medical care from your licensed healthcare provider. The information here is designed to help you make informed choices about your health. 
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