DxF Newsletter  Vol 1 Num 5.
Diagnosis Foundation
Investigating Causes, Providing Choices

 Week 5 – Depression / Body

Nerve Inflammation – Part 1 of 3

Last week, we continued our review of potential causes of clinical depression in the body domain by touching on neurotransmitters that are correlated with depression. .  This week, we’ll start part 1 of 3 regarding some of the causes of depression related to inflammation.
The inflammation factors we will be addressing fall into 3 rough categories:
1.       Allergies
2.       Chemical intolerance (foods, drugs, etc.)
3.       Chemical inflammation regulators ( cortico-steroids, interleukins  and prostaglandins)

This week we will cover allergic causes of brain inflammation.

When portions of the brain become inflamed, nerves do not function properly.  Depending on the degree of severity, they may fire too rapidly, repetitively, or conversely too slow and infrequently.  Depending on which nerves are inflamed will determine which emotions, cognitive or motor functions behave abnormally.  If some degree of inflammation is already present in the parts of the brain responsible for initiating or inhibiting depression, symptoms may be produced during episodes when inflammation is exacerbated.
The inflammation may be short lived (seconds to minutes) or chronic (years or decades).  The duration is dependent on which mechanisms are involved.

Part 1 - Allergies
 Allergies that result in elevated systemic histamines are capable of causing inflammation at any point in the body and interfering with proper nerve functioning in the brain.  True allergies are relatively fast acting, involve proteins as the allergen (the substance the body is having the allergic reaction to) and involve one component of the immune system (IgE).  Allergies may be triggered by proteins that enter the body through the respiratory or digestive tract
Allergy triggers may be diagnosed by IgE serum or intra-dermal (pin prick) tests.  Once the allergens that a person is allergic to are determined, continued diagnosis is necessary to determine why the person is allergic to those substances. 

Factors to consider here include:
  • increased penetrance of the allergen into the body,
  • excessive release of histamine,
  • insufficient control of the inflammation (which will be covered in part 3 of this series)
 Increased penetrance of allergens into the body can happen for many reasons.  Causes include increased permeability of the intestinal or respiratory tract through weakly constructed walls, damage, local inflammation, insufficient mucous or maldigestion.  Maldigestion contributes to allergies through undigested foods being eaten by intestinal bacteria that produce toxic waste products.  Diagnosing intestinal and respiratory permeability can be initiated with a serum amino acid profile. Maldigestion diagnosis may be initiated with a stool analysis for undigested food and digestive enzyme content.
Histamine release is a normal part of the body’s defense mechanisms.  Excessive release of histamine has been associated with fragility of the packets that hold the histamine in cells.  Vitamin A deficiency is a causal factor for histamine packet fragility and may be tested in the blood.

Summary of Diagnostic Testing
Allergies Triggers (What you are allergic to?)
  • IgE blood allergy test or
  • intra-dermal (pin prick)
Allergy Causes (Why are you allergic to anything?)
  • Vitamin A
  • Amino Acid profile
  • Stool Analysis – for maldigestion, digestive enzymes

Next week we will continue exploring the possible causes of depression in the body domain with Part 2 of Inflammation – Chemical Sensitivities.


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Word of the Week

Histamine is a normally found chemical in the body.  The actions of histamine include being a part of the immune system’s defense.  Histamine acts a chemical messenger from the early alert system that detects chemical intruders into the body.  The early alert system which utilizes histamine messengers includes mast cells (found in lymph nodes) and basophiles (one type of white blood cell).  When foreign proteins get into the body the mast cells and basophiles swallow and destroy them and release histamine.  Histamine then diffuses into the surrounding tissues where it will dilate local blood vessels.
The dilated vessels will allow an increased amount of blood to leak out.  This leaking blood contains additional chemical and white blood cells to help contain and eliminate any additional foreign proteins that have gotten through the body’s walls.  This redness (from dilated blood vessels) and swelling (from increased fluid leakage out of the blood vessels) is inflammation.  So histamine is the chemical messenger that initiates inflammation.
Histamine released in progressively greater amounts, will spread further through the body causing increasing inflammation at more distant sites (including the brain).  If severe enough, anaphylactic shock will be the result as too many arteries throughout the body dilate and blood pressure drops to lethal levels.
Regulating histamine releases, as well as containing the duration of its effect, is a vitally important component of the body’s defenses.  When excessively released or unopposed sufficiently by regulating chemical, inflammation can spread too far, and can affect the nervous system. Inflammation in the brain may cause depression among other symptoms depending on which nerves are most vulnerable.

Education Program - DxProtocols

OK...take a breath! We know this is a lot of information and it can be overwhelming. The information in our Spotlight is so valuable and we want to make access to the information easy! 

The DxF is committed to educating the world by investigating causes to provide choices.  Our Spotlight selections are part of our continued growing educational program. The information contained in our newsletter will be compiled into a DxProtocol resource that will be easy to reference when needed.

Is this information valuable to you? Would you like to donate to the DxProtocol program? Contact the DxF for more information.

Samples of current DxProtocols awaiting funding:                                                               

  • Depression 
  • ADHD
  • Anxiety
  • Etc.
Next week we will provide additional details of the DxProtocol program. Thank you for your continued support.

Important Note:

The information in this newsletter is not intended to replace the services of trained health professionals. You are advised to consult with your health care professional with regard to matters relating to diagnosising and treating your health, and in particular regarding symptoms that may require immediate attention. If you suspect that you have a medical problem, please seek competent medical care from your licensed healthcare provider. The information here is designed to help you make informed choices about your health. 
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