Nerve Inflammation – Part 1 of 3
Week 5 – Depression / Body
Last week, we continued our review of potential causes of clinical depression in the body domain by touching on neurotransmitters that are correlated with depression. . This week, we’ll start part 1 of 3 regarding some of the causes of depression related to inflammation.
The inflammation factors we will be addressing fall into 3 rough categories:
2. Chemical intolerance (foods, drugs, etc.)
3. Chemical inflammation regulators ( cortico-steroids, interleukins and prostaglandins)
This week we will cover allergic causes of brain inflammation.
When portions of the brain become inflamed, nerves do not function properly. Depending on the degree of severity, they may fire too rapidly, repetitively, or conversely too slow and infrequently. Depending on which nerves are inflamed will determine which emotions, cognitive or motor functions behave abnormally. If some degree of inflammation is already present in the parts of the brain responsible for initiating or inhibiting depression, symptoms may be produced during episodes when inflammation is exacerbated.
The inflammation may be short lived (seconds to minutes) or chronic (years or decades). The duration is dependent on which mechanisms are involved.
Part 1 - Allergies
Allergies that result in elevated systemic histamines are capable of causing inflammation at any point in the body and interfering with proper nerve functioning in the brain. True allergies are relatively fast acting, involve proteins as the allergen (the substance the body is having the allergic reaction to) and involve one component of the immune system (IgE). Allergies may be triggered by proteins that enter the body through the respiratory or digestive tract
Allergy triggers may be diagnosed by IgE serum or intra-dermal (pin prick) tests. Once the allergens that a person is allergic to are determined, continued diagnosis is necessary to determine why the person is allergic to those substances.
Factors to consider here include:
increased penetrance of the allergen into the body,
excessive release of histamine,
insufficient control of the inflammation (which will be covered in part 3 of this series)
Increased penetrance of allergens into the body can happen for many reasons. Causes include increased permeability of the intestinal or respiratory tract through weakly constructed walls, damage, local inflammation, insufficient mucous or maldigestion. Maldigestion contributes to allergies through undigested foods being eaten by intestinal bacteria that produce toxic waste products. Diagnosing intestinal and respiratory permeability can be initiated with a serum amino acid profile
. Maldigestion diagnosis may be initiated with a stool analysis
for undigested food and digestive enzyme content.
Histamine release is a normal part of the body’s defense mechanisms. Excessive release of histamine has been associated with fragility of the packets that hold the histamine in cells. Vitamin A deficiency is a causal factor for histamine packet fragility and may be tested in the blood.
Summary of Diagnostic Testing
Allergies Triggers (What you are allergic to?)
IgE blood allergy test or
intra-dermal (pin prick)
Allergy Causes (Why are you allergic to anything?)
Next week we will continue exploring the possible causes of depression in the body domain with Part 2 of Inflammation – Chemical Sensitivities.
Amino Acid profile
Stool Analysis – for maldigestion, digestive enzymes