Call for participation SIMcal study
Dear ESID members,
The ESID Registry defines selective IgM deficiency (sIgMdef) as a serum IgM level below 2 SDs of normal with normal levels of serum IgA, IgG and IgG subclasses, normal vaccine responses and absence of T-cell defects. It is a rare disorder about which we as yet know but little. Primary selective IgM deficiency is reported to be associated with a wide range of clinical presentations (but in many papers the ESID Registry definition is not met). As it is also found in asymptomatic individuals, its clinical significance remains uncertain. In the Primary selective IgM deficiency: clinical and laboratory features (SIMcal) study we will analyze patients with ‘true’ primary sIgMdef registered in the ESID Online Database (mostly tertiary centres) and cases retrospectively collected from the laboratory files of a Dutch large teaching hospital (Jeroen Bosch Hospital, ‘s-Hertogenbosch) to gain more insight into the clinical and laboratory phenotype.
Seventeen centres are already participating. Since there are but relatively few sIgMdef patients in the ESID Registry, we hope all of you will participate in this effort!
Participation is not that much work. Of course we will all publish the results together.
For more information, please go to: http://esid.org/Working-Parties/Registry/Studies/SIMcal-Study.
Interested in participation? Send an email to email@example.com !