The Official Newsletter of the Department of Surgery
June 2021 - Volume 10 - Issue 10

Dear Colleagues,

As another academic year draws to a close, I would like to take the time to acknowledge the efforts of our office and faculty for yet again another productive and successful year. We undertook many new initiatives, renewed support for existing ones, and upheld our clinical and academic leadership on the world stage.  We continued with our virtual annual social gatherings including:  Breakfasts with the Chair, a PGY1-2 research town hall, global surgery symposium, EDI symposia, the biennial book club, a career night for medical students interested in surgery, Gallie Day and the Gordon Murray Lecture. 
Dean Trevor Young announced a historic gift to the Faculty of Medicine (FOM) at the University of Toronto (UofT) from James and Louise Temerty, and the Temerty Foundation with an unprecedented $250M donation.
Homer Tien (General Surgery, Sunnybrook Health Sciences Centre, President and CEO of ORNGE) led Operation Remote Immunity which enabled faculty in the Department of Surgery to administer vaccinations in 31 remote Indigenous communities in a culturally respectful partnership between ORNGE and Nishnawbe Aski Nations, including clinic set-up and translation services. 
The year 2021 marked the 100th Anniversary of the discovery of insulin at the University of Toronto. Sir Frederick Banting began his training in surgery at Sick Kids Hospital, and a video commemorating this discovery and Banting’s role as a surgeon can be found at
The Department of Surgery was ranked 4th in the world by the US News and World Report for the second year in a row. 

All Surgical Residency Programs and Surgical Foundations underwent accreditation by the Royal College of Physicians and all Programs in Surgery received Full Accreditation, with a recommended next accreditation visit and external review in 2028.

In February 2021, the Department of Surgery was reviewed by Dr. Susan Reid, McMaster University; and Dr. Nita Ahuja, Yale University. 

University Rounds and guest lectures continue to play a major role in the Department in knowledge dissemination and networking. Our invited speakers this year included: Dr. Joanna Chikwe, Bigelow Lecturer; Dr. Dana A. Telem, Robin McLeod Lecturer; Dr. Steven Scherer, Ben Alman Research and Science Lecturer; Dr. Lindsey Fitzharris, Kergin Lecturer; Dr. Marcie Bowers, Balfour Lecturer; and Dr. Joseph Sakran, Tile Lecturer. Gallie Day was once again a resounding success with Dr. James Shapiro, The University of Alberta speaking on “Cell Transplantation for Diabetes 100 Years on from Insulin – The Sweetest Solution for Elimination of this Disease”. Our sixth Global Surgery Symposium was based on “The Future of Virtual Learning in Global Surgery: Augmented Reality, Artificial Intelligence, and Telesimulation”.  The inaugural Equity, Diversion and Inclusion lecture, as organized by Laura Snell and Najib Saffiedine, took place with Dr Frances Henry, Fellow of the Royal Society of Canada, speaking on “White privilege and unconscious bias”. 

Major Faculty achievements included
Najma Ahmed is the recipient of the CPSO Council Award for her advocacy work with gun control and protection.  Veronica Wadey was elected to serve on UofT Governing Council representing all Teaching Staff holding appointments in the Temerty Faculty of Medicine including clinical faculty. Gelareh Zadeh has been named as one of the 2021 Top 25 Women of Influence. Danielle Bentley is the recipient of a 2020-2021 University of Toronto Early Career Teaching Award. Robin McLeod completed her term as President of the American Surgical Association and gave her Presidential Address on the topic of "Greening the Operating Room" on Friday, April 16, 2021. Mark Bernstein is the recipient of this year’s Temerty Medicine Humanitarian award for his efforts in Global Neurosurgery. Natalie Coburn and Kazuhiro Yasufuku were elected to Fellowship within the American Surgical Association in 2020.  Katherine Howe was the 2020 Wylie Scholar recipient for her stroke research - only the third Canadian to receive this prestigious award.
I would also like to underscore several notable accomplishments of our faculty this year. Earl Bogoch has recently been named as the holder of the Brookfield Chair in Fracture Prevention; Tulin Cil has been appointed to the Gattuso Chair in Breast Surgical Oncology at University Health Network; Leodante (Leo) da Costa has been appointed as the inaugural Medical Director of the Centre for Neurovascular Intervention at Sunnybrook; Elisa Greco has been selected as UofT Vascular Surgery Residency Program Director; Mohit Kapoor has been appointed as the inaugural Tony and Shari Fell Platinum Chair in Arthritis Research; John Marshall has recently been named as the holder of an Endowed Chair in Trauma Research; Carmine Simone assumed the role of Interim Vice President, Clinical Programs, Michael Garron Hospital; Rajiv Singal became Surgeon-in-Chief and Co-Medical Director for the Surgery Health Service at Michael Garron Hospital; Jory Simpson accepted the position of Division Head for General Surgery at Unity Health, SMH, was appointed as Director of MD Program, Department of Surgery, University of Toronto and the Rae Early Career Professorship in Cancer Surgical Care; Mojgan Hodaie was appointed as Director Postgraduate Medical Education, Department of Surgery and the Greg Wilkins - Barrick Chair in International Surgery; Najma Ahmed has been appointed as Surgeon-in-Chief of Unity Health, St. Michael's Hospital; Nir Lipsman has been announced as the new residency program director for neurosurgery at the University of Toronto; Gideon Cohen has been appointed to the Dr. Bernard S. Goldman Chair in Cardiovascular Surgery; Maral Ouzounian has been appointed as the Antonio and Helga De Gasperis Chair in Clinical Trials and Outcomes Research at University Health Network; James Drake and Michael Jewett were named as Members of the Order of Canada; Girish Kulkarni has been appointed as Head, Division of Surgical Oncology, Sprott Department of Surgery, University Health Network; Geoff Fernie became a member of the Order of Ontario; Andrew Howard was appointed to Head, Division of Orthopaedic Surgery at The Hospital for Sick Children; Mary-Anne Aarts has been appointed as the new Chief of the Department of Surgery and co-Medical Director, Peri-operative Program at St. Joseph’s Hospital; Kazu Yasufuku was appointed as the Division Head of Thoracic Surgery at University Health Network and Chair of the Division of Thoracic Surgery in the Department of Surgery at the University of Toronto.
In 2020-2021 the Department of Surgery had an incredible year with $7.1M in philanthropic support raised. I extend a sincere thanks to our faculty and alumni for their continued support, and especially our leadership across the Department who give generously and dedicate a genuine effort toward building philanthropic relationships to advance excellence in research and education. Here are some of the highlights over the last year.
The Department received $2M in support of our Surgeon Scientist Training Program as part of the Temerty Foundation’s investment in the Faculty of Medicine. Two new Surgeon Scientist Trainee Awards were also established through generous gifts from Dr. Wally Peters and Julie Di Lorenzo.
The Department was also a recipient of a generous $500K gift from Dr. Neville Poy and The Honourable Dr. Vivienne Poy in support of senior resident education in aesthetic plastic surgery. Dr. Nancy McKee and her family also established a new fund with a $200K gift to support education and research in reconstructive surgery.
Additional highlights include gifts from Dr. Robin Richards in support of physician wellness and from Mark Daniels in support of research into surgical treatments of complex vascular conditions. Finally, we also continue to see significant support from our industry partners towards our educational programming and clinical and research fellowships across the Divisions.
This past year a Department of Surgery alumni newsletter was launched and is receiving above industry standard open rates (44.7%). Also for the first time, judges from the alumni were involved in Gallie Day.

Research funding continues to rise each year, and this year reached an all time high of $102,655,553.

Tess Weber retired at the end of April 2021 after 40 years with the University of Toronto.

Sadly, we lost some giants in the Department, and we extend our condolences to the family and friends of Drs. Robert Filler (Paediatric General Surgery, July 2, 2020); Neil Watters (General Surgery, September 22, 2020); Al Harrison (General Surgery, October 2020); William “Bill” Spence, (General Surgery, February 22, 2021); Lucas Murnaghan (Orthopaedic Surgeon, March 23, 2021); and Dan Stojimirovic (Orthopaedic Divisional Administrator, April 11, 2021).
As always, I am truly honoured to be leading such a capable and accomplished group of women and men across all levels of training, and at all levels of faculty appointments.  While no one can predict the future, it is a safe bet, in my opinion, that the Department of Surgery will continue to reach new milestones and landmarks that can only be dreamed of at this time.  Please enjoy the summer with your family and friends, and I hope to see you all virtually at my Annual Address, Friday, September 11th!

James T. Rutka, OC, O Ont, MD, PhD, FRCSC, FRSC, FACS, FAANS
RS McLaughlin Professor and Chair
Department of Surgery, University of Toronto

Annual Address
Save the Date

Friday, September 10, 2021
7:30 - 8:30 AM

Dr. James T. Rutka
Department of Surgery Book Club

Wednesday, July 14, 2021
6:30 PM EST

If you wish to participate, please RSVP to
Tile Lecturer
Dr. Joseph Sakran, Associate Professor of Surgery and Nursing, Associate Chief, Division of Acute Care Surgery, Director, Emergency General Surgery, Falls Church, Virginia gave the Tile Lecture on Friday, June 4, 2021.  He spoke on "Turning Public Narrative into Action: Gun Violence in America"
Applications are invited for the position of Chair of the Department of Surgery in the Temerty Faculty of Medicine at the University of Toronto.

For more details, please go here

Dr. Richard Fessler, Department of Neurosurgery, Rush University Medical Center, Chicago was the Keynote Speaker at SpineFest held virtually on Monday, June 14, 2021.  He spoke on "Minimally Invasive Surgery for Adult Scoliosis: Who, When, Why". 
MD Convocation 2021

James Rutka attended, and presented the awards from the Department of Surgery to several deserving medical students.
Michael and Amira Dan Fellowship

A special acknowledgement and tribute were made to Michael and Amira Dan for their generosity in supporting clinical neurosurgery fellowships.
Tribute to Dr. Todd Mainprize

A tribute highlighting the many contributions of Dr. Todd Mainprize to the Division of Neurosurgery at Sunnybrook, the Department of Surgery, and the Faculty of Medicine, the University of Toronto was held virtually on Tuesday, June 22, 2021.
Virtual Celebration for All Successful Promotees

A pizza party celebration via zoom was held for all promotees in the Department of Surgery, June 16, 2021.  This year, all candidates who applied for promotion were successfully promoted! Many thanks to Earl Bogoch for leading the Departmental Promotions Committee, and to Sylvia Perry for all of her assistance throughout the year!
Moji Hodaie (Neurosurgery) has been appointed as Director Postgraduate Medical Education, Department of Surgery and the Greg Wilkins - Barrick Chair in International Surgery.

Marc Jeschke (Plastic Surgery) Director, Ross Tilley Burn Centre, Sunnybrook Health Sciences Centre and his team were recently reviewed by the American Burn Association and recommended to be re-verified as an adult burn centre.

Jory Simpson (General Surgery) has been appointed as Director, MD Program, Department of Surgery, University of Toronto and the Rae Early Career Professorship in Cancer Surgical Care.

Kazuhiro Yasufuku (Thoracic Surgery) has been appointed as the F.G. Pearson – R.J. Ginsberg Chair in Thoracic Surgery at University Health Network, a Hospital-University Endowed Named Chair

Danielle Bischof received a Medical Humanities Education Grant for her submission Indigenous Cultural Safety Curriculum for Senior General Surgery Residents: Does Emotional Learning Make the Difference?
Augusto Zani (General Surgery) received an award/grant from the APSA Foundation for the research grant entitled: “Amniotic Fluid Stem Cell Extracellular Vesicles as a Novel Therapy for Pulmonary Hypertension Secondary to Congenital Diaphragmatic Hernia”.
Kim Tsoi (Orthopaedic Surgery) has been chosen as a 2021 Banting-Mitacs Discovery Award recipient for her project entitled:  Development of a Nanotherapeutic to Target Pro-Tumourigenic Immune Cells in Soft Tissue Sarcoma Lung Metastases” 
Maryam Faiz (Anatomy) a Professor in the Department of Surgery, developed a technique to 'reprogram' cells to replace those lost to stroke damage.   The article "Reprogramming the Brain for Better Recovery After Stroke" can be read here.  


Giuseppe Papia (Vascular Surgery) is Associate Professor of Surgery at the University of Toronto and the J. Ross & Patricia Quigley Chair in Limb Preservation at U of T. He was recently featured in The UofTMed Magazine Summer.  The article can be read here

Please note that only publications that denote your affiliation with the Department of Surgery, University of Toronto will be featured in this section.
Acuna SA, Dossa F, Chesney TR. Comments and Concerns on the LASER Trial. JAMA Surg. 2021 Jun 9.
Ajib K, Berjaoui MB, Herrera-Caceres J, Nason G, Tan GH, Tjong MC, Lajkosz K, Sridhar S, Fleshner NE, Zlotta AR, Catton C, Berlin A, Chung P, Kulkarni GS. Characterization and management of NMIBC recurrences after TMT: a matched cohort analysis. Urol Oncol. 2021 Jun 13:S1078-1439(21)00214-3.
Ali Hassan SM, Paleczny S, Hamilton A, Payne DM, Petsikas D, Bisleri G. Is It Feasible To Implant Sutureless Valves In Presence of Diseased Aortic Root And Aortic Aneurysm?
Ann Thorac Surg. 2021 May 22:S0003-4975(21)00888-2.
Aversa M, Martinu T, Patriquin C, Cypel M, Barth D, Ghany R, Ma J, Keshavjee S, Singer LG, Tinckam K. Long-term outcomes of sensitized lung transplant recipients after peri-operative desensitization. Am J Transplant. 2021 May 31.
Baxter T, To T, Chiu M, Camp M, Howard A. Factors affecting management of children's low-risk distal radius fractures in the emergency department: a population-based retrospective cohort study. CMAJ Open. 2021 Jun 15;9(2):E659-E666.
Boutet A, Madhavan R, Elias GJB, Joel SE, Gramer R, Ranjan M, Paramanandam V, Xu D, Germann J, Loh A, Kalia SK, Hodaie M, Li B, Prasad S, Coblentz A, Munhoz RP, Ashe J, Kucharczyk W, Fasano A, Lozano AM. Predicting optimal deep brain stimulation parameters for Parkinson's disease using functional MRI and machine learning. Nat Commun. 2021 May 24;12(1):3043.
Capitanio U, Autorino R, Bandini M, Briganti A, Cheng L, Cooperberg MR, Dehò F, Gallina A, Klotz L, Lane BR, Montironi R, Salonia A, Stief C, Tombal B, Montorsi F. Reply to Nicolas Mottet, Olivier Rouviere, and Theodorus H. van der Kwast. Incidental Prostate Cancer: A Real Need for Expansion in Guidelines? Eur Urol Oncol. In press: Incidental Prostate Cancer: An Example of How Important Guidelines Are, Especially When Evidence Is Limited.Eur Urol Oncol. 2021 May 31:S2588-9311(21)00110-3.
Cheng TW, Farber A, Levin SR, Malas MB, Garg K, Patel VI, Kayssi A, Rybin D, Hasley RB, Siracuse JJ. Perioperative Outcomes for Centers Routinely Admitting Postoperative Endovascular Aortic Aneurysm Repair to the ICU. J Am Coll Surg. 2021 Jun;232(6):856-863.
Cheung DC, Alibhai SMH, Martin LJ, Komisarenko M, Dharma C, Warde P, Sridhar SS, Fleshner NE, Kulkarni GS, Finelli A. Real World Practice Patterns and Predictors of Continuous versus Intermittent ADT Use for Prostate Cancer in Older Men. J Urol. 2021 May 25:101097JU0000000000001876.
Corbett K, Sharma A, Pond GR, Brastianos PK, Das S, Sahgal A, Jerzak KJ. Central Nervous System-Specific Outcomes of Phase 3 Randomized Clinical Trials in Patients With Advanced Breast Cancer, Lung Cancer, and Melanoma. JAMA Oncol. 2021 May 20:e211359.
Crivellaro P, Tafur M, George R, Muradali D. Diagnostic interval for non-screening patients undergoing mammography during the COVID-19 pandemic. Eur Radiol. 2021 Jun 18.
Dai C, Zhang Z, Shan G, Chu LT, Huang Z, Moskovstev S, Librach C, Jarvi K, Sun Y. Advances in sperm analysis: techniques, discoveries and applications. Nat Rev Urol. 2021 Jun 1.
De Vloo P, Boutet A, Elias GJB, Gramer RM, Joel SE, Llinas M, Kucharczyk W, Fasano A, Hamani C, Lozano AM. Dysgeusia induced and resolved by focused ultrasound thalamotomy: case report. J Neurosurg. 2021 Jun 18:1-6.
Dekirmendjian A, Retrouvey H, Jakubowski J, Sander B, Binhammer P. Assessing New Technologies in Surgery: Case Example of Acute Primary Repair of the Thumb Ulnar Collateral Ligament. J Hand Surg Am. 2021 Jun 3:S0363-5023(21)00197-0.
Deng MX, Tam DY, Fremes SE. Commentary: A Puzzle With Many "Moving" Parts. Semin Thorac Cardiovasc Surg. 2021 Jun 4;S1043-0679(21)00277-X.

Deniffel D, Healy GM, Dong X, Ghai S, Salinas-Miranda E, Fleshner N, Hamilton R, Kulkarni G, Toi A, van der Kwast T, Zlotta A, Finelli A, Perlis N, Haider MA. Avoiding Unnecessary Biopsy: MRI-based Risk Models versus a PI-RADS and PSA Density Strategy for Clinically Significant Prostate Cancer. Radiology. 2021 May 25:204112.
Domínguez-Gil B, Ascher N, Capron AM, Gardiner D, Manara AR, Bernat JL, Miñambres E, Singh JM, Porte RJ, Markmann JF, Dhital K, Ledoux D, Fondevila C, Hosgood S, Van Raemdonck D, Keshavjee S, Dubois J, McGee A, Henderson GV, Glazier AK, Tullius SG, Shemie SD, Delmonico FL. Correction to: Expanding controlled donation after the circulatory determination of death: statement from an international collaborative. Intensive Care Med. 2021 Jun 15.
Donovan LK, Delaidelli A, Joseph SK, Bielamowicz K, Fousek K, Holgado BL, Manno A, Srikanthan D, Gad AZ, Van Ommeren R, Przelicki D, Richman C, Ramaswamy V, Daniels C, Pallota JG, Douglas T, Joynt ACM, Haapasalo J, Nor C, Vladoiu MC, Kuzan-Fischer CM, Garzia L, Mack SC, Varadharajan S, Baker ML, Hendrikse L, Ly M, Kharas K, Balin P, Wu X, Qin L, Huang N, Stucklin AG, Morrissy AS, Cavalli FMG, Luu B, Suarez R, De Antonellis P, Michealraj A, Rastan A, Hegde M, Komosa M, Sirbu O, Kumar SA, Abdullaev Z, Faria CC, Yip S, Hukin J, Tabori U, Hawkins C, Aldape K, Daugaard M, Maris JM, Sorensen PH, Ahmed N, Taylor MD. Author Correction: Locoregional delivery of CAR T cells to the cerebrospinal fluid for treatment of metastatic medulloblastoma and ependymoma. Nat Med. 2021 Jun;27(6):1117-1120.
Drynan D, Leroux TS, Zywiel MG. Acute Postoperative Pulmonary Embolism Detected at Home by a Patient's Personal Activity Monitor: A Case Report. JBJS Case Connect. 2021 Jun 8;11(2).
Elias GJB, Germann J, Neudorfer C, Namasivayam AA, Loh A, Gramer RM, Ibrahim GM, Valiante T, Tomaszczyk JC, McAndrews MP, Kucharczyk W, Boutet A, Lozano AM. Impact of mesial temporal lobe resection on brain structure in medically refractory epilepsy. World Neurosurg. 2021 Jun 15:S1878-8750(21)00870-6.
Eliathamby D, Gutierrez M, Liu A, Ouzounian M, Forbes TL, Tan KT, Chung J. Ascending Aortic Length and Its Association With Type A Aortic Dissection. J Am Heart Assoc. 2021 Jun 14:e020140.
Elsolh B, Ko M, Cheung V, Gomez D. Oesophageal rupture from a pneumatic blast injury: an unusual mechanism of blunt oesophageal trauma. BMJ Case Rep. 2021 Jun 11;14(6):e242218.
Erickson AW, Habbous S, Wright F, Lofters AK, Jerzak KJ, Das S. Assessing the Association of Targeted Therapy and Intracranial Metastatic Disease. JAMA Oncol. 2021 Jun 3:e211600.
Falegan OS, Jarvi K, Vogel HJ, Hyndman ME. Seminal plasma metabolomics reveals lysine and serine dysregulation as unique features distinguishing between prostate cancer tumors of Gleason grades 6 and 7. Prostate. 2021 Jun 7.
Finelli A, Beer TM, Chowdhury S, Evans CP, Fizazi K, Higano CS, Kim J, Martin L, Saad F, Saarela O. Comparison of Joint and Landmark Modeling for Predicting Cancer Progression in Men With Castration-Resistant Prostate Cancer: A Secondary Post Hoc Analysis of the PREVAIL Randomized Clinical Trial. JAMA Netw Open. 2021 Jun 1;4(6):e2112426.
Furlan JC, Tator CH. In Reply: A Scoping Review of Registered Clinical Studies on Mild Traumatic Brain Injury and Concussion (2000-2019). Neurosurgery. 2021 Jun 5:nyab191.
Gattini D, Roberts AJ, Wales PW, Beath SV, Evans HM, Hind J, Mercer D, Wong T, Yap J, Belza C, Huysentruyt K, Avitzur Y. Trends in Pediatric Intestinal Failure: A Multicenter, Multinational Study. J Pediatr. 2021 Jun 18:S0022-3476(21)00555-2.
Genovesi LA, Millar A, Tolson E, Singleton M, Hassall E, Kojic M, Brighi C, Girard E, Andradas C, Kuchibhotla M, Bhuva DD, Endersby R, Gottardo NG, Bernard A, Adolphe C, Olson JM, Taylor MD, Davis MJ, Wainwright BJ. Systems pharmacogenomics identifies novel targets and clinically actionable therapeutics for medulloblastoma. Genome Med. 2021 Jun 21;13(1):103.
Germann J, Elias GJB, Neudorfer C, Boutet A, Chow CT, Wong EHY, Parmar R, Gouveia FV, Loh A, Giacobbe P, Kim SJ, Jung HH, Bhat V, Kucharczyk W, Chang JW, Lozano AM. Potential optimization of focused ultrasound capsulotomy for obsessive compulsive disorder. Brain. 2021 Jun 18:awab232.
Glennie RA, Canizares M, Perruccio AV, Abraham E, Nicholls F, Nataraj A, Phan P, Attabib N, Johnson MG, Richardson E, McIntosh G, Ahn H, Fisher CG, Manson N, Thomas K, Rampersaud YR. The impact of pathoanatomical diagnosis on elective spine surgery patient expectations: a Canadian Spine Outcomes and Research Network study. J Neurosurg Spine. 2021 May 21:1-8.
Gomez D, Simpson AN, Sue-Chue-Lam C, de Mestral C, Dossa F, Nantais J, Wilton AS, Urbach D, Austin PC, Baxter NN. A population-based analysis of the impact of the COVID-19 pandemic on common abdominal and gynecological emergency department visits. CMAJ. 2021 May 25;193(21):E753-E760.
Gorgen A, Sapisochin G. Re: Hepatobiliary Scintigraphy to Increase the Safety in Right Lobe Living Donor Liver Transplantation: Not Just a Matter of Age and Remnant Volume.Transplantation. 2021 Jun 1;105(6):e64.

Gorgen A, Sapisochin G. Reply to "Reducing the Safety Limit for Remnant Liver Volume in Living Donor Hepatectomy: Are We Pushing the Envelope Off the Edge?". Transplantation. 2021 Jun 1;105(6):e62.
Griffiths AL, Donnan LT, Iobst CA, Kelley SP, Bouchard M, Narayanan UG. The Gait Outcomes Assessment List for Children With Lower Limb Difference (GOAL-LD): Assessment of Reliability and Validity. J Pediatr Orthop. 2021 Jun 3.
Guidolin K, Catton J, Rubin B, Bell J, Marangos J, Munro-Heesters A, Stuart-McEwan T, Quereshy F. Ethical decision making during a healthcare crisis: a resource allocation framework and tool. J Med Ethics. 2021 May 21:medethics-2021-107255.
Guo MH, Appoo JJ, Wells GA, Chu M, Ouzounian M, Fortier J, Boodhwani M. Protocol for a randomised controlled trial for Treatment in Thoracic Aortic Aneurysm: Surgery versus Surveillance (TITAN: SvS). BMJ Open. 2021 May 26;11(5):e052070.

Hall JA, Schemitsch CE, Vicente MR, Dehghan N, Nauth A, Nowak LL, Schemitsch EH, McKee MD. Operative vs. Non-operative Treatment of Acute Displaced Distal Clavicle Fractures: A Multicentre Randomized Controlled Trial. J Orthop Trauma. 2021 Jun 14.
Harrington J, AlSubaihin A, Dupuis L, Kannu P, Mendoza-Londono R, Howard A. Diagnostic utility of next-generation sequence genetic panel testing in children presenting with a clinically significant fracture history. Arch Osteoporos. 2021 Jun 5;16(1):88.
Hassan A, Ouzounian M, Dagenais F, El-Hamamsy I, Moon MC, Pozeg Z, McClure RS, Yamashita M, Peterson MD, MacArthur R, Appoo JJ, Chu MWA. Development of Quality Indicators for the Management of Acute Type A Aortic Dissection. Can J Cardiol. 2021 Jun 3:S0828-282X(21)00291-9.
Hazekamp MG, Barron DJ, Dangel J, Homfray T, Jongbloed MRM, Voges I. Consensus document on optimal management of patients with common arterial trunk. Cardiol Young. 2021 May 21:1-25.
Hendriks EJ, Lynch J, Swaminathan SK, Nicholson P, Agid R, Radovanovic I, Pereira VM, terBrugge K, Krings T. Embolization strategies for intracranial dural arteriovenous fistulas with an isolated sinus: a single-center experience in 20 patients. J Neurointerv Surg. 2021 Jun 3:neurintsurg-2021-017652.
Horton JD, Davies JC, Vaitaitis VJ, Rist TM, Agur AMR, Day TA. Aberrant Hypoglossal Nerve During Neck Dissection. JAMA Otolaryngol Head Neck Surg. 2021 Jun 3.
Hrincu V, McDonald PJ, Connolly MB, Harrison MJ, Ibrahim GM, Naftel RP, Chiong W, Alam A, Ribary U, Illes J. Choice and Trade-offs: Parent Decision Making for Neurotechnologies for Pediatric Drug-Resistant Epilepsy. J Child Neurol. 2021 Jun 2:8830738211015010.
Hung PS, Noorani A, Zhang JY, Tohyama S, Laperriere N, Davis KD, Mikulis DJ, Rudzicz F, Hodaie M. Regional brain morphology predicts pain relief in trigeminal neuralgia. Neuroimage Clin. 2021 May 25;31:102706.
Jacob-Brassard J, Al-Omran M, Stukel TA, Mamdani M, Lee DS, De Mestral C. Validation of Diagnosis and Procedure Codes for Revascularization for Peripheral Artery Disease in Ontario Administrative Databases. Clin Invest Med. 2021 Jun 14;44(2):E36-43.
Jiang SM, Ali Hassan SM, Nguyen G, Bisleri G. Zone 0 frozen elephant trunk for type A retrograde acute aortic dissection following endovascular stenting of the arch. J Card Surg. 2021 Jun;36(6):2124-2126.
Khoshbin A, Hoit G, Nowak LL, Daud A, Steiner M, Juni P, Ravi B, Atrey A. The association of preoperative blood markers with postoperative readmissions following arthroplasty. Bone Jt Open. 2021 Jun;2(6):388-396.
Kinoshita-Ise M, Ohyama M, Ramjist JM, Foster FS, Yang VXD, Sachdeva M, Sade S, Shear NH. Ultra high-frequency ultrasound with seventy-MHz transducer in hair disorders: Development of a novel noninvasive diagnostic methodology. J Dermatol Sci. 2021 Jun;102(3):167-176.
Knotkova H, Hamani C, Sivanesan E, Le Beuffe MFE, Moon JY, Cohen SP, Huntoon MA. Neuromodulation for chronic pain. Lancet. 2021 May 29;397(10289):2111-2124.
Kokorovic A, So AI, Serag H, French C, Hamilton RJ, Izard JP, Nayak JG, Pouliot F, Saad F, Shayegan B, Aprikian A, Rendon RA. Canadian Urological Association guideline on androgen deprivation therapy: Adverse events and management strategies. Can Urol Assoc
2021 Jun;15(6):E307-E322.
Kokorovic A, So AI, Serag H, French C, Hamilton RJ, Izard JP, Nayak JG, Pouliot F, Saad F, Shayegan B, Aprikian A, Rendon RA. Canadian Urological Association guideline on androgen deprivation therapy: Adverse events and management strategies - Executive summary. Can Urol Assoc J. 2021 Jun;15(6):159-161.
Koyle MA. Go gentle into that good night. Can Urol Assoc J. 2021 Jun;15(6):153-154.
Lau E, Lee C, Li B, Pierro A. Endoplasmic reticulum stress in the acute intestinal epithelial injury of necrotizing enterocolitis. Pediatr Surg Int. 2021 Jun 12.
Lavi A, Breau RH, Mallick R, Kapoor A, Finelli A, So A, Pouliot F, Tanguay S, Lavallée LT, Rendon R, Fairey A, Drachenberg DE, Lattouf JB, Maloni R, Power NE. Adrenalectomy During Radical Nephrectomy- Incidence and Oncologic Outcomes from the Canadian Kidney Cancer Information System (CKCis) -A Modern Era, Nationwide, Multicenter Cohort. Urology. 2021 Jun 12:S0090-4295(21)00482-9.
Lee J, Roche-Nagle G. Permanent IVC filter strut penetration into an abdominal aortic aneurysm. BMJ Case Rep. 2021 Jun 7;14(6):e241962.
Levin M, McKechnie T, Kruse CC, Aldrich K, Grantcharov TP, Langerman A. Surgical data recording in the operating room: a systematic review of modalities and metrics. Br J Surg. 2021 Jun 22;108(6):613-621.
Lightner AL, Steele SR, Delaney CP, Lavryk O, Vaidya P, McMichael J, Jia X, de Buck van Overstraeten A, Brar MS. Colonic Disease Recurrence following Proctectomy with End Colostomy for Anorectal Crohn's Disease. Colorectal Dis. 2021 Jun 22.
Lobo N, Brooks NA, Zlotta AR, Cirillo JD, Boorjian S, Black PC, Meeks JJ, Bivalacqua TJ, Gontero P, Steinberg GD, McConkey D, Babjuk M, Alfred Witjes J, Kamat AM. 100 years of Bacillus Calmette-Guérin immunotherapy: from cattle to COVID-19. Nat Rev Urol. 2021 Jun 15.
Luc JGY, Ad N, Nguyen TC; COVID-19 North American Cardiac Surgery Survey Working Group Collaborators, Arora RC, Balkhy HH, Bender EM, Bethencourt DM, Bisleri G, Boyd D, Chu MWA, de la Cruz KI, DeAnda A, Engelman DT, Farkas EA, Fedoruk LM, Fiocco M, Forcillo J, Fradet G, Fremes SE, Gammie JS, Geirsson A, Gerdisch MW, Girard LN, Kaiser CA, Kaneko T, Kent WDT, Khabbaz KR, Khoynezhad A, Kiaii B, Lee R, Legare JF, Lehr EJ, MacArthur RGG, McCarthy PM, Mehall JR, Merrill WH, Moon MR, Ouzounian M, Peltz M, Perrault LP, Preventza O, Ramchandani M, Ramlawi B, Salenger R, Sekela ME, Sellke FW, Stulak JM, Sutter FP, Timek TA, Whitman G, Williams JB, Wong DR, Yanagawa B, Ye J, Zeigler SM. Cardiac surgeons' concerns, perceptions, and responses during the COVID-19 pandemic. J Card Surg. 2021 Jun 12.
Makhdoum A, Dhingra NK, Kirubaharan A, Eikelboom R, Luc J, Dagher O, Bierer J, Cartier A, Vaillancourt O, Vo TX, Forgie K, Bisleri G, Yau TM, Verma S, Yanagawa B. Ticagrelor use and practice patterns among Canadian cardiac surgeons. J Card Surg. 2021 May 24.
Malkiel S, Sayed BA, Ng V, Wall DA, Rozmus J, Schreiber RA, Faytrouni F, Siddiqui I, Chiang KY, Avitzur Y. Sequential paternal haploidentical donor liver and HSCT in EPP allow discontinuation of immunosuppression post-organ transplant. Pediatr Transplant. 2021 Jun 2:e14040.
Marcus G, Qiu F, Manoragavan R, Ko DT, Elbaz-Greener G, Chung JCY, Sud M, Farkouh ME, Madan M, Fremes SE, Wijeysundera HC. Temporal Trends and Drivers of Heart Team Utilization in Transcatheter Aortic Valve Replacement: A Population-Based Study in Ontario, Canada. J Am Heart Assoc. 2021 Jun 22:e020741.
McEvoy CM, Clotet-Freixas S, Tokar T, Pastrello C, Reid S, Batruch I, RaoPeters AAE, Kaths JM, Urbanellis P, Farkona S, Van JAD, Urquhart BL, John R, Jurisica I, Robinson LA, Selzner M, Konvalinka A. Normothermic Ex-vivo Kidney Perfusion in a Porcine Auto-Transplantation Model Preserves the Expression of Key Mitochondrial Proteins: An Unbiased Proteomics Analysis. Mol Cell Proteomics. 2021 May 22:100101.
McLeod R. ASA Presidential Address: Greening the Operating Room. Ann Surg. 2021 Jun 16.
Montroni I, Saur NM, Shahrokni A, Suwanabol PA, Chesney TR. Surgical Considerations for Older Adults With Cancer: A Multidimensional, Multiphase Pathway to Improve Care.
Moore GWK, Semple JL. Himalaya Air Quality Impacts From the COVID-19 Lockdown Across the Indo-Gangetic Plain. Geohealth. 2021 Jun 1;5(6):e2020GH000351.
Nasute Fauerbach PV, Tyryshkin K, Rodrigo SP, Rudan J, Fichtinger G, Reedijk M, Varma S, Berman DM. Lack of definitive presurgical pathological diagnosis is associated with inadequate surgical margins in breast-conserving surgery. Eur J Surg Oncol. 2021 Jun 4:S0748-7983(21)00542-4.
Nessim C, Raut CP, Callegaro D, Barretta F, Miceli R, Fairweather M, Blay JY, Strauss D, Rutkowski P, Ahuja N, Gonzalez R, Grignani G, Quagliuolo V, Stoeckle E, Lahat G, De Paoli A, Pillarisetty VG, Canter RJ, Mullen JT, Pennacchioli E, van Houdt W, Swallow CJ, Schrage Y, Cardona K, Fiore M, Gronchi A, Bagaria SP. ASO Visual Abstract: An Analysis of Differentiation Changes and Outcomes at the First Recurrence of Retroperitoneal Liposarcoma by the Transatlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG). Ann Surg Oncol. 2021 Jun 20.
Noltes ME, Metman MJH, Heeman W, Rotstein L, van Ginhoven TM, Vriens MR, Engelsman AF, Boerma CE, Brouwers AH, van Dam GM, Pasternak JD, Kruijff S. A Novel and Generic Workflow of Indocyanine Green Perfusion Assessment Integrating Standardization and Quantification Towards Clinical Implementation. Ann Surg. 2021 Jun 10.

Pincus D, Widdifield J, Palmer KS, Paterson JM, Li A, Huang A, Wasserstein D, Lapointe-Shaw L, Brown A, Taljaard M, Ivers NM. Effects of hospital funding reform on wait times for hip fracture surgery: a population-based interrupted time-series analysis. BMC Health Serv Res. 2021 Jun 13;21(1):576.
Ramsay L, Richardson M, Sander B, Rahal M, Wu D, Setterfield M, Woodward G, Al-Omran M; COVID-19 Mod Collab group, de Mestral C. Predicting surgery waiting list volumes and health outcomes among people with an abdominal aortic aneurysm. Br J Surg. 2021 Jun 22;108(6):e221-e223.
Roth J, Constantini S, Ekstein M, Weiner HL, Tripathi M, Chandra PS, Cossu M, Rizzi M, Bollo RJ, Machado HR, Santos MV, Keating RF, Oluigbo CO, Rutka JT, Drake JM, Jallo GI, Shimony N, Treiber JM, Consales A, Mangano FT, Wisoff JH, Teresa Hidalgo E, Bingaman WE, Gupta A, Erdemir G, Sundar SJ, Benifla M, Shapira V, Lam SK, Fallah A, Maniquis CAB, Tisdall M, Chari A, Cinalli G, Blount JP, Dorfmüller G, Christine Bulteau, Uliel-Sibony S. Epilepsy surgery in infants up to 3 months of age: Safety, feasibility, and outcomes: A multicenter, multinational study. Epilepsia. 2021 Jun 14.
Sahgal A, Myrehaug SD, Siva S, Masucci GL, Maralani PJ, Brundage M, Butler J, Chow E, Fehlings MG, Foote M, Gabos Z, Greenspoon J, Kerba M, Lee Y, Liu M, Liu SK, Thibault I, Wong RK, Hum M, Ding K, Parulekar WR; trial investigators. Stereotactic body radiotherapy versus conventional external beam radiotherapy in patients with painful spinal metastases: an open-label, multicentre, randomised, controlled, phase 2/3 trial. Lancet Oncol. 2021 Jun 11:S1470-2045(21)00196-0.
Sarica C, Yamamoto K, Loh A, Elias GJB, Boutet A, Madhavan R, Germann J, Zemmar A, Gwun D, Tasserie J, Andrade DM, Hodaie M, Kalia SK, Wennberg RA, Lozano AM. Blood oxygen level-dependent (BOLD) response patterns with thalamic deep brain stimulation in patients with medically refractory epilepsy. Epilepsy Behav. 2021 Jun 18;122:108153.
Skinnider MA, Rogalski J, Tigchelaar S, Manouchehri N, Prudova A, Jackson AM, Nielsen K, Jeong J, Chaudhary S, Shortt K, Gallagher-Kurtzke Y, So K, Fong A, Gupta R, Okon EB, Rizzuto MA, Dong K, Streijger F, Belanger L, Ritchie L, Tsang A, Christie S, Mac-Thiong JM, Bailey C, Ailon T, Charest-Morin R, Dea N, Wilson JR, Dhall S, Paquette S, Street J, Fisher CG, Dvorak MF, Shannon C, Borchers C, Balshaw R, Foster LJ, Kwon BK. Proteomic portraits reveal evolutionarily conserved and divergent responses to spinal cord injury. Mol Cell Proteomics. 2021 Jun 12:100096.
Stacchiotti S, Miah AB, Frezza AM, Messiou C, Morosi C, Caraceni A, Antonescu CR, Bajpai J, Baldini E, Bauer S, Biagini R, Bielack S, Blay JY, Bonvalot S, Boukovinas I, Bovee JVMG, Boye K, Brodowicz T, Callegaro D, De Alava E, Deoras-Sutliff M, Dufresne A, Eriksson M, Errani C, Fedenko A, Ferraresi V, Ferrari A, Fletcher CDM, Garcia Del Muro X, Gelderblom H, Gladdy RA, Gouin F, Grignani G, Gutkovich J, Haas R, Hindi N, Hohenberger P, Huang P, Joensuu H, Jones RL, Jungels C, Kasper B, Kawai A, Le Cesne A, Le Grange F, Leithner A, Leonard H, Lopez Pousa A, Martin Broto J, Merimsky O, Merriam P, Miceli R, Mir O, Molinari M, Montemurro M, Oldani G, Palmerini E, Pantaleo MA, Patel S, Piperno-Neumann S, Raut CP, Ravi V, Razak ARA, Reichardt P, Rubin BP, Rutkowski P, Safwat AA, Sangalli C, Sapisochin G, Sbaraglia M, Scheipl S, Schöffski P, Strauss D, Strauss SJ, Sundby Hall K, Tap WD, Trama A, Tweddle A, van der Graaf WTA, Van De Sande MAJ, Van Houdt W, van Oortmerssen G, Wagner AJ, Wartenberg M, Wood J, Zaffaroni N, Zimmermann C, Casali PG, Dei Tos AP, Gronchi A. Epithelioid hemangioendothelioma, an ultra-rare cancer: a consensus paper from the community of experts. ESMO Open. 2021 Jun;6(3):100170.
Stevens RM, Silverman A, Pascasio J, Sun J, Throckmorton A, Mulinari L, Cusimano RJ. Multi-disciplinary frameworks for the treatment of primary cardiac sarcoma. J Card Surg. 2021 Jun 15.
Tanaka D, Nedadur R, Yanagawa B. Rapid deployment valves: Another tool in the toolbox. J Card Surg. 2021 May 31.

Tanaka D, Tam DY, Fremes SE. Commentary: Rapid Deployment Does Not Necessarily Warrant Rapid Adoption. Semin Thorac Cardiovasc Surg. 2021 Jun 2:S1043-0679(21)00259-8.
Targum SD, Fosdick L, Drake KE, Rosenberg PB, Burke AD, Wolk DA, Foote KD, Asaad WF, Sabbagh M, Smith GS, Lozano AM, Lyketsos CG. Effect of Age on Clinical Trial Outcome in Participants with Probable Alzheimer's Disease. J Alzheimers Dis. 2021 Jun 16.
Tillmann BW, Guttman MP, Nathens AB, de Mestral C, Kayssi A, Haas B. The timing of amputation of mangled lower extremities does not predict post-injury outcomes and mortality: a retrospective analysis from the ACS TQIP database. J Trauma Acute Care Surg. 2021 May 25.
Ulndreaj A, Li A, Chen Y, Besla R, Pacheco S, Althagafi MG, Cybulsky MI, Lindsay T, Robbins CS, Byrne JS. Adventitial recruitment of Lyve-1- macrophages drives aortic aneurysm in an angiotensin-2-based murine model. Clin Sci (Lond). 2021 May 28;135(10):1295-1309.
Venkatraghavan L, Royan N, Boyle SL, Dinsmore M, Lu N, Cushman K, Massicotte EM, Prabhu A. Effect of reversal of residual neuromuscular blockade on the amplitude of motor evoked potentials: a randomized controlled crossover study comparing sugammadex and placebo. Neurol Sci. 2021 May 26.
Verburg N, Barthel FP, Anderson KJ, Johnson KC, Koopman T, Yaqub MM, Hoekstra OS, Lammertsma AA, Barkhof F, Pouwels PJW, Reijneveld JC, Rozemuller AJM, Beliën JAM, Boellaard R, Taylor MD, Das S, Costello JF, Vandertop WP, Wesseling P, de Witt Hamer PC, Verhaak RGW. Spatial concordance of DNA methylation classification in diffuse glioma. Neuro Oncol. 2021 May 28:noab134.
Verma S, Latter DA, Bonow RO. Failed Mitral TEER: Are There Lessons for Decision Making? J Am Coll Cardiol. 2021 May 21:S0735-1097(21)04977-9.
Verma S, Leiter LA, Zinman B, Sharma A, Mattheus M, Fitchett D, George J, Ofstad AP, Kosiborod MN, Wanner C, Inzucchi SE. Time to cardiovascular benefits of empagliflozin: a post hoc observation from the EMPA-REG OUTCOME trial. ESC Heart Fail. 2021 Jun 16.
Villafuerte CJ, Shultz DB, Laperriere N, Gentili F, Heaton R, van Prooijen M, Cusimano MD, Hodaie M, Schwartz M, Berlin A, Payne D, Kalia SK, Bernstein M, Wang J, Zadeh G, Spears J, Tsang DS. Radiation Dose Rate, Biologically Effective Dose, and Tumor Characteristics on Local Control and Toxicity After Radiosurgery for Acoustic Neuromas. World Neurosurg. 2021 Jun 16:S1878-8750(21)00817-2.
Wagg AS, Herschorn S, Carlsson M, Fernet M, Oelke M. What are the chances of improvement or cure from overactive bladder? A pooled responder analysis of efficacy and treatment emergent adverse events following treatment with fesoterodine. Neurourol Urodyn. 2021 May 26.

Yeganeh A, Alibhai FJ, Tobin SW, Lim F, Wu J, Li S, Weisel RD, Li RK. Age-related defects in autophagy alter the secretion of paracrine factors from bone marrow mononuclear cells. Aging (Albany NY). 2021 Jun 4;13(11):14687-14708.
Youn S, Wong SA, Chrystoja C, Tomlinson G, Wijeysundera HC, Bell CM, Gagliardi AR, Baxter NN, Takata J, Sandhu L, Urbach DR. Bias estimation in study design: a meta-epidemiological analysis of transcatheter versus surgical aortic valve replacement. BMC Surg. 2021 Jun 7;21(1):285.
Yuan B, Aziz MRF, Li S, Wu J, Li D, Li RK. An electro-spun tri-component polymer biomaterial with optoelectronic properties for neuronal differentiation. Acta Biomater. 2021 May 31:S1742-7061(21)00346-9.
Yuen N, Szulc-Lerch KU, Li YQ, Morshead CM, Mabbott DJ, Wong CS, Nieman BJ. Metformin Effects on Brain Development Following Cranial Irradiation in a Mouse Model.Neuro Oncol. 2021 May 27;noab131.

Zamzam A, Syed MH, Harlock J, Eikelboom J, Singh KK, Abdin R, Qadura M. Urinary fatty acid binding protein 3 (uFABP3) is a potential biomarker for peripheral arterial disease. Sci Rep. 2021 May 26;11(1):11061.
Zeng K, Drummond NM, Ghahremani A, Saha U, Kalia SK, Hodaie M, Lozano AM, Aron AR, Chen R. Fronto-subthalamic phase synchronization and cross-frequency coupling during conflict processing. Neuroimage. 2021 May 30;238:118205.
Zhu A, Deng S, Greene B, Tsang M, Palter VN, Jayaraman S. Helping the Surgeon Recover: Peer-to-Peer Coaching after Bile Duct Injury. J Am Coll Surg. 2021 Jun 7:S1072-7515(21)00374-4.
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