Quality & Best Practices in the Department of Surgery: Patient-Centered Care Initiative

There are a few discipline-wide health movements that have generated the traction and interest quite like Quality Improvement has over the past several years.  Broadly defined as a systematic approach to making changes that lead to better patient outcomes, stronger system performance, and enhanced professional development, Quality Improvement is an approach that requires continuous efforts from both patients and providers alike. 
Our Department of Surgery is certainly no exception – nor stranger – to this approach.  The last few years have brought about significant changes and improvements in the realm of Quality Improvement across our Toronto hospitals system.  Dr. Robin McLeod and her clinical team have led the establishment of new standards of patient care since 2006 including the development of the Best Practices in General Surgery (BPIGs) guidelines and a Quality & Best Practices Committee that has been meeting regularly for the past two years.  The committee has successfully completed an in-depth study of readmission rates for index procedures across the surgical disciplines and will soon be publishing their findings, along with recommendations for reducing these rates through standardized patient care.  They have also implemented a Quality Improvement resident curriculum.
I should like to share the committee’s newest endeavor with you – The Department of Surgery Patient Engagement Project.  This will be a series of three, one day meetings with 32 patient and 16 surgeon representatives as well as 8 representatives from nursing and hospital administration as well as 8 representatives from nursing and hospital administration representing all specialties across the U. of T teaching hospitals.  The objectives of these meetings will be to develop a patient-centred framework for the ideal surgical experience in order to identify current gaps in care, and to develop strategies to close these gaps in care.  At the end of the project we will have a fully organized Patient and Family Advisory Council for the Department of Surgery as well as a strategic plan to improve the patient surgical experience across the department.  The meeting dates are April 15, June 17 and October 21, 2016.  This is a very exciting project and may be one of the first of its kind across Canada and United States for departments of surgery such as ours.
It is our expectation that the development of patient-centered guidelines for the Department of Surgery will in turn improve priority domains of patient-centered care in the university affiliated hospitals across Toronto.
I should like to thank Robin McLeod and her Quality & Best Practices committee, and Joanna Giddens, Strategic Plan Implementation Co-ordinator, for helping us move these initiatives forward so effectively.
What is Quality Improvement? Health Quality Ontario., 17 March 2016


James T. Rutka, MD, PhD, FRCSC
RS McLaughlin Chair


Department of Surgery University Rounds
Palmer Lecture
Friday, April 1, 2016, 7:30 - 8:30 a.m.
Mount Sinai Hospital, 18th Floor Auditorium
David A. Kooby, MD, FACS
Professor of Surgery
Chief of Emory Surgery in the Northern Arc Emory University School of Medicine, Department of Surgery
“Minimally Invasive Pancreatic Resection (MIPR)”
2nd University of Toronto Surgical Ethics Course
Wednesday, April 6, 2016, 9 a.m. – 4 p.m.
Chestnut Conference Centre, 89 Chestnut Street
2nd Annual Balfour Lecture in Surgical Ethics
Wednesday, April 6, 2016, 5-6 p.m.
Peter Gilgan Centre for Research Tower, CRL Event Room 1
686 Bay Street
Dr. Gretchen Schwarze, University of Wisconsin
“High Stakes Surgical Decision and Unwanted Care”
Update in General Surgery
April 6, 2016
Hilton Downtown, 145 Richmond Street, West

2nd Annual Alan and Susan Hudson Lectureship
Friday, April 15, 2016, 7:30 – 8:30 a.m.
Toronto Western Hospital, Main Auditorium
West Wing 2-401
Dr. Patrick J. Gullane, University of Toronto
“Skull Base Surgery – Thirty Years of Evolution and Revolutions”

Gallie Day
FRIDAY MAY 13, 2016
MaRS Centre Lower Concourse
101 College Street
Gordon Murray Lecturer
Mohit Bhandari MD, PhD, FRCSC
Professor and Academic Chair, Division of Orthopaedic Surgery
Canada Research Chair in Evidence-Based Orthopaedics
Associate Chair-Research, Department of Surgery, McMaster University
3rd Annual Global Health Day, “Health Beyond Borders”
Thursday, June 9, 2016, noon – 5 p.m.
McLeod Auditorium, Faculty of Medicine, U. of T.
Admission – Complimentary.  Registration – Mandatory.
Monday, June 13, 2016
MaRS Centre Lower Concourse
101 College Street
Dr. K. Daniel Riew
Professor of Orthopedic Surgery
Columbia University Medical Center
“The Post-operative Patient with Persistent or Recurrent Symptoms”
Department of Surgery University Rounds
Harland Smith Lecture
Dr. Julian Pribaz, Professor of Surgery, Harvard Medical School was the Harland Smith Lecturer on March 4, 2016 at SMH.  The title of his talk was
"Preparation for Facial Transplantation – Lessons Learned from Anatomical Dissections and Clinical Experience with our first 7 cases.”  Left to right:  R. Zuker, C. Morshead, J. Pribaz, C. Forrest.

Appointed as Head, Division of Neurosurgery, Sunnybrook Health Sciences Centre
Todd Mainprize
(Neurosurgery) has been appointed as Division Head, Neurosurgery at Sunnybrook.  Dr. Mainprize has been interim Division Head in Neurosurgery for over two yeaers.  He has created an environment in the Division that nurtures academic surgeons, advocates strongly for Neurosurgery at the provincial level, and is engaging a large number of initiatives across both Sunnybrook and the University - from education to transforming the delivery of care.

Appointment to the Crean Hotson Chair in Skull Base Surgery at University Health Network
Fred Gentili (Neurosurgery) has been appointed as the Crean Hotson Chair in Skull Base Surgery at University Health Network for 5 years. 

Strategy for Patient-Oriented Research (SPOR)
Karen Davis
(Neurosurgery) is one of the PIs in a $25M group grant from the CIHR SPOR network for their Chronic Pain Network.  This network is led by Dr. Norm Buckley, Professor and Chair of Anesthesia for McMaster University's Michael G. DeGroote School of Medicine and Scientific Director of the Michael G. DeGroote Institute for Pain Research and Care.  This project will have patients working with researchers, healthcare professionals, educators and government policy advisors to increase care access for chronic pain sufferers. 

New Appointment in Neurosurgery, The Hospital for Sick Children
Douglas Cochrane (Neurosurgery) is doing a 15 month sabbatical at The Hospital for Sick Children in the Division of Pediatric Neurosurgery.  Dr. Cochrane has been the Chair of the BC Patient Safety & Quality Council, and Provincial Patient Safety & Quality Officer for British Columbia. He is Professor at the University of British Columbia in Neurosurgery.  Interestingly, he did a pediatric neurosurgery fellowship at the Hospital for Sick Children in 1981. He has served as head of the Section of Surgery and Surgeon-in-Chief, BC Children’s Hospital and Children’s and Women’s Health Centre of British Columbia 1991-2001. 

Calling all Softball Players
Looking for players to form a team(s) against the neurosurgery group going to NYC in June for a Charity Tournament (which could include the neurosurgeons who are unable to make the trip.  A diamond has been booked on Sunday, May 29th at McCleary Park from 9 a.m. – noon.  If you have any questions or wish to play, please let Stephanie know –

Continuing Appointment Reviews (CARs)
The following Continuing Appointment Reviews (CARs) took place in January under the leadership of Ori Rotstein, Associate Chair, Department of Surgery.  
Steven McCabe is an Associate Professor in the Department of Surgery, University of Toronto and Director of Hand Surgery Program, Surgery, University of Toronto. Dr. McCabe graduated from The University of Toronto Medical School in 1980 and trained in Plastic and Reconstructive Surgery in London, Ontario. He completed Hand Fellowships at Sunnybrook Health Science Center and the Workers’ Compensation Board of Ontario and at the Kleinert Institute in Louisville Kentucky. Dr. McCabe has been the President of the American Society for Peripheral Nerve and the American Association for Hand Surgery. His work was recently highlighted in Toronto with the performance of the first arm transplant in Canada.  His research areas are carpal tunnel syndrome, diagnosis and management, and decision modeling as applied to the upper extremity.  From left to right:  C. Forrest, S. McCabe, S. Hofer. 

Ivan Radovanovic is an Assistant Professor within the Division of Neurosurgery, Department of Surgery, University of Toronto and a faculty member at Toronto Western Hospital.  Dr. Radovanovic obtained his medical degree at the University of Geneva, Switzerland in 1998. In 2003  he received his PhD at the Institute of Neuropathology at the University of Zurich.  Between 2010-2011, Dr. Radovanovic was staff neurosurgeon at Geneva University Hospitals, Department of Clinical Neurosciences, Division of Neurosurgery. In 2013, he was recruited to the Division of Neurosurgery with a staff appointment at Toronto Western Hospital.  He is currently an Assistant Professor in the Department of Surgery. His research is focused on the surgical management of ruptured and unruptured aneurysms, AVMs and dural arteriovenous fistulae, using minimally invasive techniques such as supraorbital and lateral supraorbital craniotomies.  From left to right:  S. Keshavjee, I. Radovanovic, M. Tymianski


AmericanCollSurgeons ‏@AmCollSurgeons Mar 26
The Surgeons as Leaders course this June will provide surgeons with skills essential to effective leadership: 
Dr. Eric Hoskins ‏@DrEricHoskins Mar 26
Today is Epilepsy Awareness Day. Approximately 1 in 100 Canadians have epilepsy. @EpilepsyOntario #PurpleDay
UofT VascularSurgery ‏@UofTVascular Mar 24
Interesting article"Amps in Canada"(via #pubmedontap) by @ahmedkayssi @PMunkCardiacCtr @UHN_Surgery @UofTSurgery 

darina ‏@darina_landa Mar 20
darina Retweeted My Reconstruction
Great piece @DrToniZhong! @UofTSurgery @uoftmedicine
darina added,
My Reconstruction @UHN_BRP
Today's @TorontoStar: @DrToniZhong's humanitarian trip 2 #Bangladesh helping burn victims @marinacjimenez #inspiring
Peter WT Pisters ‏@ppisters Mar 12
Scientists grow eye lens from patient's own stem cells, restoring vision. #Science leads to cures: 
Avery Nathens ‏@injurydr Mar 12
Congratulations to @dctrjpbyrne from @uofttrauma @uoftsurgery: 1st place prize in @acstrauma paper competition 
UofT Dept of Surgery ‏@UofTSurgery Mar 10
Bernard and Ryna Langer being congratulated last night for completion of Langer Chair at Origin Restaurant!
UofT Dept of Surgery ‏@UofTSurgery Mar 4
Dr. Pribaz about to begin lecture @UofTSurgery Harland Smith Lecture, SMH


Najma A. Ahmed (General Surgery) is the recipient of the 2016 Royal College / AMS Donald Richards Wilson Award.  The award was established to honour and acknowledge the contribution of Dr. Donald R. Wilson to medical education. It is given annually to a medical educator or an identified leader who has demonstrated excellence in integrating the CanMEDS roles into a Royal College or other health related training program. The CanMEDS roles and competency framework have been recognized both nationally and internationally as essential components of medical education, equipping physicians with the attitudes, knowledge, and skills required to provide the diversity of services to meet the needs of society.
Cindi Morshead (Anatomy) is the recipient of the 2016 Excellence in Undergraduate Teaching in Life Sciences Award.  The award recognizes sustained excellence in teaching, coordination and/or development of undergraduate lecture or seminar courses in Arts and Science offered by the Basic Sciences Departments in the Faculty of Medicine.

Robert Nam (Urology) is the recipient of a PARO (Professional Association of Residents of Ontario) 2016 Excellence in Clinical Teaching Award.   The Clinical Teaching Awards acknowledge the essential role that good clinical teachers play in the training of physicians. Residents are asked to outline the qualities that make their nominee an excellent teacher including: patient care, quality of bedside teaching, and interest in the trainees’ personal development and well-being.

Fahima Osman (General Surgery NYGH) was named Torontonian of the Year by Post City Magazine:

David Wasserstein and Ujash Sheth (Orthopaedics) won the Sports Health T. David Sisk Award for the most outstanding review paper published in Sports Health in 2015.  Their paper was entitled “A Systematic Review of Failed Anterior Cruciate Ligament Reconstruction with Autograft Compared with Allograft in Young Patients”.

Kazuhiro Yasufuku (Thoracic Surgery) is the recipient of the Ivan Silver Innovation Award from the Faculty of Medicine Continuing Professional Development (CPD) Office. 

Abdallah FW, Dwyer T, Chan VW, Niazi AU, Ogilvie-Harris DJ, Oldfield S, Patel R, Oh J, Brull R.  IV and Perineural Dexmedetomidine Similarly Prolong the Duration of Analgesia after Interscalene Brachial Plexus Block: A Randomized, Three-arm, Triple-masked, Placebo-controlled Trial.  Anesthesiology. 2016 Mar;124(3):683-95.

Abdallah FW, Whelan DB, Chan VW, Prasad GA, Endersby RV, Theodoropolous J, Oldfield S, Oh J, Brull R.  Adductor Canal Block Provides Noninferior Analgesia and Superior Quadriceps Strength Compared with Femoral Nerve Block in Anterior Cruciate Ligament Reconstruction.  Anesthesiology. 2016 Mar 3.

Al Harbi F, Tabatabaeefar L, Jewett MA, Finelli A, O'Malley M, Atri M.  Enhancement Threshold of Small (< 4 cm) Solid Renal Masses on CT.AJR Am J Roentgenol. 2016 Mar;206(3):554-8.

Alotaibi NM, Ibrahim GM, Jalal H, Perez-Ordonez B, Hodaie M, Kalia SK.  Subdural Collection as Initial Presentation of Granulomatosis With Polyangiitis.  JAMA Neurol. 2016 Mar 21.

Amini-Nik S, Jeschke MG.  WHAT'S NEW IN SHOCK? MARCH 2016.  Shock. 2016 Mar;45(3):239-40.

Au K, Bharadwaj S, Venkatraghavan L, Bernstein M.  Outpatient brain tumor craniotomy under general anesthesia.  J Neurosurg. 2016 Mar 4:1-6.

Bhindi B, Xie WY, Kulkarni GS, Hamilton RJ, Nesbitt M, Finelli A, Zlotta AR, Evans A, van der Kwast TH, Alibhai SM, Trachtenberg J, Fleshner NE.  Influence of Metabolic Syndrome on Prostate Cancer Stage, Grade and Overall Recurrence Risk in Men Undergoing Radical Prostatectomy.  Urology. 2016 Mar 22.

Burtenshaw SM, Cannell AJ, McAlister ED, Siddique S, Kandel R, Blackstein ME, Swallow CJ, Gladdy RA.  Toward Observation as First-line Management in Abdominal Desmoid Tumors.  Ann Surg Oncol. 2016 Mar 28.

Catt CJ, Hamilton GM, Fish J, Mireskandari K, Ali A.  Ocular manifestations of Stevens-Johnson syndrome and toxic epidermal necrolysis in children.  Am J Ophthalmol. 2016 Mar 23.

Chruscinski A, Huang FY, Nguyen A, Lioe J, Tumiati LC, Kozuszko S, Tinckam KJ, Rao V, Dunn SE, Persinger MA, Levy GA, Ross HJ.  Generation of Antigen Microarrays to Screen for Autoantibodies in Heart Failure and Heart Transplantation.  PLoS One. 2016 Mar 11;11(3):e0151224.

Cleary SP, Han HS, Yamamoto M, Wakabayashi G, Asbun HJ.  The comparative costs of laparoscopic and open liver resection: a report for the 2nd International Consensus Conference on Laparoscopic Liver Resection.  Surg Endosc. 2016 Mar 1.

Cordeiro E, Gervais MK, Shah PS, Look Hong NJ, Wright FC.  Sentinel Lymph Node Biopsy in Thin Cutaneous Melanoma: A Systematic Review and Meta-Analysis.  Ann Surg Oncol. 2016 Mar 1.

David TE.  Mitral valve repair: Is the cheese factory moving?  J Thorac Cardiovasc Surg. 2016 Mar 8.

Dekutoski MB, Clarke MJ, Rose P, Luzzati A, Rhines LD, Varga PP, Fisher CG, Chou D, Fehlings MG, Reynolds JJ, Williams R, Quraishi NA, Germscheid NM, Sciubba DM, Gokaslan ZL, Boriani S; AOSpine Knowledge Forum Tumor.  Osteosarcoma of the spine: prognostic variables for local recurrence and overall survival, a multicenter ambispective study.  J Neurosurg Spine. 2016 Mar 4:1-10.

Fatehi M, Ahuja CS, Wang S, Ginsberg HJ.  Uremic tumoral calcinosis in the cervical spine: case report.  J Neurosurg Spine. 2016 Mar 4:1-5.

Fedorko L, Bowen JM, Jones W, OreopoulosG, Goeree R, Hopkins RB, O’Reilly DJ.  Hyperbaric Oxygen Therapy Does Not Reduce Indications for Amputation in Patients with Diabetes with Nonhealing Ulcers of the Lower Limb:  A Prospective, Double-Blind, Randomized Controlled Clinical Trial.  Diabetes Care.  2016 Mar; 39(3)392-9. 

Finnerty CC, Herndon DN, Lee JO, Rodriguez NA, Al-Haj IH, Wurzer P, Calhoun BR, Jeschke MG.  Morbidity and mortality in severely burned children with Clostridium difficile-associated diarrhea.  Surgery. 2016 Mar 25.

Grosheva M, Nohroudi K, Schwarz A, Rink S, Bendella H, Sarikcioglu L, Klimaschewski L, Gordon T, Angelov DN.  Comparison of trophic factors' expression between paralyzed and recovering muscles after facial nerve injury. A quantitative analysis in time course.  Exp Neurol. 2016 Mar 2;279:137-148.

Gupta AA, Donen RM, Sung L, Boydell KM, Lo KC, Stephens D, Pritchard S, Portwine C, Maloney AM, Lorenzo AJ.  Testicular Biopsy for Fertility Preservation in Prepubertal Boys with Cancer: Identifying Preferences for Procedure and Reactions to Disclosure Practices.  J Urol. 2016 Mar 3.

Hänggi D, Etminan N, Steiger HJ, Johnson M, Peet MM, Tice T, Burton K, Hudson B, Turner M, Stella A, Heshmati P, Davis C, Faleck HJ, Macdonald RL.  A Site-Specific, Sustained-Release Drug Delivery System for Aneurysmal Subarachnoid Hemorrhage.  Neurotherapeutics. 2016 Mar 2.

Hashimoto K, Kim H, Oishi H, Chen M, Iskender I, Sakamoto J, Ohsumi A, Guan Z, Hwang D, Waddell TK, Cypel M, Liu M, Keshavjee S.  Annexin V homodimer protects against ischemia reperfusion-induced acute lung injury in lung transplantation.  J Thorac Cardiovasc Surg. 2016 Mar;151(3):861-9.

Herridge MS, Chu LM, Matte A, Tomlinson G, Chan L, Thomas C, Friedrich JO, Mehta S, Lamontagne F, Levasseur M, Ferguson ND, Adhikari NK, Rudkowski JC, Meggison H, Skrobik Y, Flannery J, Bayley M, Batt J, Dos Santos C, Abbey SE, Tan A, Lo V, Mathur S, Parotto M, Morris D, Flockhart L, Fan E, Lee CM, Wilcox ME, Ayas N, Choong K, Fowler R, Scales DC, Sinuff T, Cuthbertson BH, Rose L, Robles P, Burns S, Cypel M, Singer L, Chaparro C, Chow CW, Keshavjee S, Brochard L, Hebert P, Slutsky AS, Marshall JC, Cook D, Cameron JI; RECOVER Program Investigators (Phase 1: towards RECOVER) and the Canadian Critical Care Trials Group.  The RECOVER Program: Disability Risk Groups & One Year Outcome after ≥ 7 Days of Mechanical Ventilation.  Am J Respir Crit Care Med. 2016 Mar 14.

Honey CR, Hamani C, Kalia SK, Sankar T, Picillo M, Munhoz RP, Fasano A, Panisset M.  Deep Brain Stimulation Target Selection for Parkinson's Disease.  Can J Neurol Sci. 2016 Mar 15:1-6.

Jeschke MG, Pinto R, Costford SR, Amini-Nik S.  Threshold age and burn size associated with poor outcomes in the elderly after burn injury.  Burns. 2016 Mar;42(2):276-81.

Jhas S, Pirouzmand F.  Obtuse-angled Laminotomy as a Modification of Multilevel Laminectomy for Spinal Cord Decompression.  Clin Spine Surg. 2016 Mar;29(2):49-51.

Kalsi-Ryan S, Beaton D, Ahn H, Askes H, Drew B, Curt A, Popovic MR, Wang J, Verrier MC, Fehlings MG. Responsiveness, Sensitivity, and Minimally Detectable Difference of the Graded and Redefined Assessment of Strength, Sensibility, and Prehension, Version 1.0. J Neurotrauma. 2016 Feb 1;33(3):307-14.

Kamdar SN, Ho LT, Kron KJ, Isserlin R, van der Kwast T, Zlotta AR, Fleshner NE, Bader G, Bapat B.  Dynamic interplay between locus-specific DNA methylation and hydroxymethylation regulates distinct biological pathways in prostate carcinogenesis.  Clin Epigenetics. 2016 Mar 15;8:32.

Kayssi A, de Mestral C, Forbes TL, Roche-Nagle G. Predictors of hospital readmissions after lower extremity amputations in Canada. J Vasc Surg. 2016 Mar;63(3):688-95.

Knudsen BS, Kim HL, Erho N, Shin H, Alshalalfa M, Lam LL, Tenggara I, Chadwich K, Van Der Kwast T, Fleshner N, Davicioni E, Carroll PR, Cooperberg MR, Chan JM, Simko JP.  Application of a Clinical Whole-Transcriptome Assay for Staging and Prognosis of Prostate Cancer Diagnosed in Needle Core Biopsy Specimens.  J Mol Diagn. 2016 Mar 3.

Krishna V, Hodaie M.  Editorial: Operating outside the operating room: how do we measure the implications?  J Neurosurg. 2016 Mar 25:1-2.

Krishnatry R, Zhukova N, Guerreiro Stucklin AS, Pole JD, Mistry M, Fried I, Ramaswamy V, Bartels U, Huang A, Laperriere N, Dirks P, Nathan PC, Greenberg M, Malkin D, Hawkins C, Bandopadhayay P, Kieran MW, Manley PE, Bouffet E, Tabori U.  Clinical and treatment factors determining long-term outcomes for adult survivors of childhood low-grade glioma: A population-based study.  Cancer. 2016 Mar 10.

Leão RR, Richard PO, Jewett MA.  The role of biopsy for small renal masses.  Int J Surg. 2016 Mar 5.
Lee JY.  Editorial Comment.  J Urol. 2016 Mar 18.

Lenke LG, Fehlings MG, Shaffrey CI, Cheung KM, Carreon L, Dekutoski MB, Schwab FJ, Boachie-Adjei O, Kebaish KM, Ames CP, Qiu Y, Matsuyama Y, Dahl BT, Mehdian H, Pellisé-Urquiza F, Lewis SJ, Berven SH. Neurologic Outcomes of Complex Adult Spinal Deformity Surgery: Results of the Prospective, Multicenter Scoli-RISK-1 Study. Spine (Phila Pa 1976). 2016 Feb;41(3):204-12.

Lista F, Austin RE, Singh Y, Ahmad J.  Reply: Vertical Scar Reduction Mammaplasty.  Plast Reconstr Surg. 2016 Mar;137(3):636e-7e.

Lorenzo AJ, Braga LH.  Decisions, Decisions, Decisions.  J Urol. 2016 Mar;195(3):551-3.

Macadam SA, Zhong T, Weichman K, Papsdorf M, Lennox PA, Hazen A, Matros E, Disa J, Mehrara B, Pusic AL.  Quality of Life and Patient-Reported Outcomes in Breast Cancer Survivors: A Multicenter Comparison of Four Abdominally Based Autologous Reconstruction Methods.  Plast Reconstr Surg. 2016 Mar;137(3):758-71.

Maekawa M, Yang Y, Fairn GD.  Perfringolysin O Theta Toxin as a Tool to Monitor the Distribution and Inhomogeneity of Cholesterol in Cellular Membranes.  Toxins (Basel). 2016 Mar 8;8(3).

Mayne IP, Brydges R, Moktar J, Murnaghan ML.  Development and Assessment of a Distal Radial Fracture Model as a Clinical Teaching Tool.  J Bone Joint Surg Am. 2016 Mar 2;98(5):410-6.

Mazine A, Badiwala M, Cohen G.  Year in review: complex valve reconstruction.  Curr Opin Cardiol. 2016 Mar;31(2):154-61.

McArthur C, Laprade J, Giangregorio LM.  Suggestions for Adapting Yoga to the Needs of Older Adults with Osteoporosis.  J Altern Complement Med. 2016 Mar;22(3):223-6.

Mordant P, McRae K, Cho J, Keshavjee S, Waddell TK, Feld R, de Perrot M.  Impact of induction therapy on postoperative outcome after extrapleural pneumonectomy for malignant pleural mesothelioma: does induction-accelerated hemithoracic radiation increase the surgical risk?  Eur J Cardiothorac Surg. 2016 Mar 22.

Nadi M, Ahmad T, Huang A, Hawkins C, Bouffet E, Kulkarni AV.  Atypical Teratoid Rhabdoid Tumor Diagnosis after Partial Resection of Dysembryoplastic Neuroepithelial Tumor: Case Report and Review of the Literature.  Pediatr Neurosurg. 2016 Mar 16.

Nagoshi N, Nakashima H, Fehlings MG. Commentary: Preclinical Validation of Multilevel Intraparenchymal Stem Cell Therapy in the Porcine Spinal Cord. Neurosurgery. 2016 Feb;78(2):E309.

Nagoshi N, Tetreault LA, Nakashima H, Nouri A, Arnold P, Zileli M, Tan G, Kopjar B, Fehlings MG.  Do Caucasians and East Asians have Different Outcomes Following Surgery for the Treatment of Degenerative Cervical Myelopathy? Results from the Prospective Multicenter AOSpine International Study.  Spine (Phila Pa 1976). 2016 Mar 10.

Nakashima H, Tetreault L, Nagoshi N, Nouri A, Arnold P, Yukawa Y, Toyone T, Tanaka M, Zhou Q, Fehlings MG.  Comparison of Outcomes of Surgical Treatment for Ossification of the Posterior Longitudinal Ligament Versus Other Forms of Degenerative Cervical Myelopathy: Results from the Prospective, Multicenter AOSpine CSM-International Study of 479 Patients.  J Bone Joint Surg Am. 2016 Mar 2;98(5):370-8.

Nam RK, Benatar T, Wallis CJ, Amemiya Y, Yang W, Garbens A, Naeim M, Sherman C, Sugar L, Seth A.  MiR-301a regulates E-cadherin expression and is predictive of prostate cancer recurrence.  Prostate. 2016 Mar 15.

Nassiri F, Ibrahim GM, Badhiwala JH, Witiw CD, Mansouri A, Alotaibi NM, Macdonald RL.  A Propensity Score-Matched Study of the Use of Non-steroidal Anti-inflammatory Agents Following Aneurysmal Subarachnoid Hemorrhage.  Neurocrit Care. 2016 Mar 21.

Nater A, Fehlings MG.  Survival and clinical outcomes in patients with metastatic epidural spinal cord compression after spinal surgery: a prospective, multicenter, observational cohort study.  Chin J Cancer. 2016 Mar 16;35(1):27.

Nazari M, Ni NC, Ludke A, Li SH, Guo J, Weisel RD, Li RK.  Mast cells promote proliferation and migration and inhibit differentiation of mesenchymal stem cells through PDGF.  J Mol Cell Cardiol. 2016 Mar 17.

Oner FC, Jacobs WC, Lehr AM, Sadiqi S, Post MW, Aarabi B, Chapman JR, Dvorak  MF, Fehlings MG, Kandziora F, Rajasekaran S, Vaccaro AR. Toward the Development of a Universal Outcome Instrument for Spine Trauma: A Systematic Review and Content Comparison of Outcome Measures Used in Spine Trauma Research Using the ICF as Reference. Spine (Phila Pa 1976). 2016 Feb;41(4):358-67.

Orlando G, Law PJ, Palin K, Tuupanen S, Gylfe A, Hänninen U, Cajuso T, Tanskanen T, Kondelin J, Kaasinen E, Sarin AP, Kaprio J, Eriksson JG, Rissanen H, Knekt P, Pukkala E, Jousilahti P, Salomaa V, Ripatti S, Palotie A, Järvinen H, Renkonen-Sinisalo L, Lepistö A, Böhm J, Meklin JP, Al-Tassan NA, Palles C, Martin L, Barclay E, Tenesa A, Farrington S, Timofeeva MN, Meyer BF, Wakil SM, Campbell H, Smith CG, Idziaszczyk S, Maughan TS, Kaplan R, Kerr R, Kerr D, Buchanan DD, Win AK, Hopper J, Jenkins M, Lindor NM, Newcomb PA, Gallinger S, Conti D, Schumacher F, Casey G, Taipale J, Cheadle JP, Dunlop MG, Tomlinson IP, Aaltonen LA, Houlston RS.  Variation at 2q35 (PNKD and TMBIM1) influences colorectal cancer risk and identifies a pleiotropic effect with inflammatory bowel disease.  Hum Mol Genet. 2016 Mar 22.

Ouzounian M, Lindsay TF, Forbes TL. Remote ischemic preconditioning and thoracoabdominal aneurysm repair: Can an arm save a cord (or legs)? J Thorac Cardiovasc Surg. 2016 Mar;151(3):616-7.

Pei Y, Liu KW, Wang J, Garancher A, Tao R, Esparza LA, Maier DL, Udaka YT, Murad N, Morrissy S, Seker-Cin H, Brabetz S, Qi L, Kogiso M, Schubert S, Olson JM, Cho YJ, Li XN, Crawford JR, Levy ML, Kool M, Pfister SM, Taylor MD, Wechsler-Reya RJ.  HDAC and PI3K Antagonists Cooperate to Inhibit Growth of MYC-Driven Medulloblastoma.  Cancer Cell. 2016 Mar 14;29(3):311-23.

Ramaswamy V, Remke M, Adamski J, Bartels U, Tabori U, Wang X, Huang A, Hawkins C, Mabbott D, Laperriere N, Taylor MD, Bouffet E. Medulloblastoma subgroup-specific outcomes in irradiated children: who are the true high-risk patients? Neuro Oncol. 2016 Feb;18(2):291-7.
Ramaswamy V, Taylor MD. Fall of the Optical Wall: Freedom from the Tyranny of the Microscope Improves Glioma Risk Stratification. Cancer Cell. 2016 Feb 8;29(2):137-8.

Reck Dos Santos P, Sakamoto J, Chen M, Linacre V, Arce C, Liu M, Waddell TK, Keshavjee S, Cypel M.  Modified In Vivo Lung Perfusion for Local Chemotherapy: A Preclinical Study With Doxorubicin.  Ann Thorac Surg. 2016 Mar 4.

Reznikov R, Binko M, Nobrega JN, Hamani C.  Deep Brain Stimulation in Animal Models of Fear, Anxiety and Post-Traumatic Stress Disorder.  Neuropsychopharmacology. 2016 Mar 2.

Satkunendrarajah K, Nassiri F, Karadimas SK, Lip A, Yao G, Fehlings MG. Riluzole promotes motor and respiratory recovery associated with enhanced neuronal survival and function following high cervical spinal hemisection. Exp Neurol. 2016 Feb;276:59-71.

Scheer AS, Zih FS, Maki E, Koch CA, McCready DR.  Post-mastectomy Radiation: Should Subtype Factor into the Decision?  Ann Surg Oncol. 2016 Mar 23.

Shamji MF, Mohanty C, Massicotte EM, Fehlings MG. The Association of Cervical Spine Alignment with Neurologic Recovery in a Prospective Cohort of Patients with Surgical Myelopathy: Analysis of a Series of 124 Cases. World Neurosurg. 2016 Feb;86:112-9.

Strauss I, Taha K, Krishna V, Hodaie M.  Younger age predicts greater effectiveness of spinal cord stimulation for chronic pain.  Acta Neurochir (Wien). 2016 Mar 11.

Szasz P, Louridas M, de Montbrun S, Harris KA, Grantcharov TP.  Consensus-based training and assessment model for general surgery.  Br J Surg. 2016 Mar 23.

Tamayo-Orrego L, Wu CL, Bouchard N, Khedher A, Swikert SM, Remke M, Skowron P, Taylor MD, Charron F.  Evasion of Cell Senescence Leads to Medulloblastoma Progression.  Cell Rep. 2016 Mar 15.

Tao MJ, Roche-Nagle G. First bite syndrome: a complication of carotid endarterectomy. BMJ Case Rep. 2016 Mar 18; 2016.

Tata A, Gribble A, Ventura M, Ganguly M, Bluemke E, Ginberg H, Jaffray D, Ifa D, Vitkin A, Zarrine-Asfar A. Wide-field tissue polarimetry allows accelerated tumor margin assessment by ambient mass spectrometry. Chemical Science.  2016, 7, 2162-2169.

Thompson EM, Hielscher T, Bouffet E, Remke M, Luu B, Gururangan S, McLendon RE, Bigner DD, Lipp ES, Perreault S, Cho YJ, Grant G, Kim SK, Lee JY, Rao AA, Giannini C, Li KK, Ng HK, Yao Y, Kumabe T, Tominaga T, Grajkowska WA, Perek-Polnik M, Low DC, Seow WT, Chang KT, Mora J, Pollack IF, Hamilton RL, Leary S, Moore AS, Ingram WJ, Hallahan AR, Jouvet A, Fèvre-Montange M, Vasiljevic A, Faure-Conter C, Shofuda T, Kagawa N, Hashimoto N, Jabado N, Weil AG, Gayden T, Wataya T, Shalaby T, Grotzer M, Zitterbart K, Sterba J, Kren L, Hortobágyi T, Klekner A, László B, Pócza T, Hauser P, Schüller U, Jung S, Jang WY, French PJ, Kros JM, van Veelen MC, Massimi L, Leonard JR, Rubin JB, Vibhakar R, Chambless LB, Cooper MK, Thompson RC, Faria CC, Carvalho A, Nunes S, Pimentel J, Fan X, Muraszko KM, López-Aguilar E, Lyden D, Garzia L, Shih DJ, Kijima N, Schneider C, Adamski J, Northcott PA, Kool M, Jones DT, Chan JA, Nikolic A, Garre ML, Van Meir EG, Osuka S, Olson JJ, Jahangiri A, Castro BA, Gupta N, Weiss WA, Moxon-Emre I, Mabbott DJ, Lassaletta A, Hawkins CE, Tabori U, Drake J, Kulkarni A, Dirks P, Rutka JT, Korshunov A, Pfister SM, Packer RJ, Ramaswamy V, Taylor MD.  Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis.  Lancet Oncol. 2016 Mar 11.

Ting K, Aitken KJ, Penna F, Samiei AN, Sidler M, Jiang JX, Ibrahim F, Tolg C, Delgado-Olguin P, Rosenblum N, Bägli DJ.  Uropathogenic E.coli (UPEC) Infection Induces Proliferation through Enhancer of Zeste Homologue 2 (EZH2).  PLoS One. 2016 Mar 10;11(3):e0149118.

Toor GK, Harris JE, Escobar M, Yoshida K, Velikonja D, Rizoli S, Cusimano M, Cullen N, Sokoloff S, Colantonio A. Long-Term Health Service Outcomes Among Women With Traumatic Brain Injury. Arch Phys Med Rehabil. 2016 Feb;97(2 Suppl):S54-63.

Traub F, Singh J, Dickson BC, Leung S, Mohankumar R, Blackstein ME, Razak AR, Griffin AM, Ferguson PC, Wunder JS.  Efficacy of denosumab in joint preservation for patients with giant cell tumour of the bone.  Eur J Cancer. 2016 Mar 15;59:1-12. .

Tsao AS, Scagliotti GV, Bunn PA Jr, Carbone DP, Warren GW, Bai C, de Koning HJ, Yousaf-Khan AU, McWilliams A, Tsao MS, Adusumilli PS, Rami-Porta R, Asamura H, Van Schil PE, Darling GE, Ramalingam SS, Gomez DR, Rosenzweig KE, Zimmermann S, Peters S, Ignatius Ou SH, Reungwetwattana T, Jänne PA, Mok TS, Wakelee HA, Pirker R, Mazières J, Brahmer JR, Zhou Y, Herbst RS, Papadimitrakopoulou VA, Redman MW, Wynes MW, Gandara DR, Kelly RJ, Hirsch FR, Pass HI.  Scientific Advances in Lung Cancer 2015.  J Thorac Oncol. 2016 Mar 21.

Tso MK, Ibrahim GM, Macdonald RL. Predictors of Shunt-Dependent Hydrocephalus Following Aneurysmal Subarachnoid Hemorrhage. World Neurosurg. 2016 Feb;86:226-32.

Turel MK, Bernstein M.  Outpatient neurosurgery.  Expert Rev Neurother. 2016 Mar 17:1-12.

Wallis CJ, Mahar AL, Choo R, Herschorn S, Kodama RT, Shah PS, Danjoux C, Narod SA, Nam RK.  Second malignancies after radiotherapy for prostate cancer: systematic review and meta-analysis.  BMJ. 2016 Mar 2;352:i851.

Wilson JR, Voth J, Singh A, Middleton J, Jaglal SB, Singh JM, Mainprize TG, Yee A, Fehlings MG. Defining the Pathway to Definitive Care and Surgical Decompression after Traumatic Spinal Cord Injury: Results of a Canadian Population-Based Cohort Study. J Neurotrauma. 2016 Feb 11.

Zhang YN, Xie BD, Sun L, Chen W, Jiang SL, Liu W, Bian F, Tian H, Li RK.  Phenotypic switching of vascular smooth muscle cells in the 'normal region' of aorta from atherosclerosis patients is regulated by miR-145.  J Cell Mol Med. 2016 Mar 15.

Zittan E, Wong-Chong N, Ma GW, Mcleod RS, Silverberg MS, Cohen Z.  Modified 2-stage ileal pouch-anal anastomosis results in lower rate of anastomotic leak compared to traditional 2-stage surgery for ulcerative colitis.  J Crohns Colitis. 2016 Mar 7.

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