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MESSAGE FROM THE CHAIR

Best Practices in Faculty Searches
The collective talent of the Department of Surgery rests on our recruitment of exceptional faculty members who strategically enhance our mission. As you know, virtually all appointments to the Department of Surgery are a product of a search process which enables Search Committees to identify the best candidates for a given position.   In this regard, the Department of Surgery has been exemplary in holding searches for well over the past decade.  While the search process has been a good one, this past year I tasked Peter Ferguson, Tom Forbes, and Robin Richards to generate “best practices” in faculty searches in the Department of Surgery.  I am delighted to inform you that the document they created has been reviewed by members of the Executive and Senior Advisory Committees, amended, and now adopted as policy in the Department of Surgery.
 
In general terms, the Search Committee is a broadly representative group of individuals whose membership must be approved by the Department Chair and/or Surgeon-in-Chief.  Membership includes the Hospital Division Head, members of the Division, the University Division Chair, Surgeon-in-Chief, Student representatives, Research Institute delegate, and Department of Surgery Chair, among others.  The Search Committee must reflect a broad diversity of backgrounds including, race, ethnicity and gender. 
           
In the new best practices document, it is stressed that all discussion must be kept entirely confidential;  any personal biases for/against a candidate must be stated at the outset;  deliberations must avoid discrimination on any basis listed in the Ontario Human Rights Code; reference checks and due diligence must be conducted systematically; and decisions are made, wherever possible, based on consensus of the committee.
 
The interview of candidates during the search process is intended to provide both the committee members and the candidates with sufficient time to ask the necessary questions of one another.
 
At times, making the decision can be challenging given the considerable qualifications of candidates applying for the position.  In the end, the search process provides a layer of transparency to faculty appointments which was not necessarily the case two decades ago. 
 
I should like to thank Peter Ferguson and colleagues for finalizing the new best practices in faculty searches document which I strongly believe will hold the Department of Surgery in good stead for many years to come.   For those interested in seeing the full policy, please email Stephanie Neilson directly for your copy (s.neilson@utoronto.ca). 

Sincerely,  


James T. Rutka, MD, PhD, FRCSC
RS McLaughlin Chair

UPCOMING EVENTS

Department of Surgery University Rounds
 
Robin McLeod Lecture
Friday, December 2, 2016, 7:30 – 8:30 a.m.
Mount Sinai Hospital
Auditorium, 600 University Avenue
 
Dr. May Lynn Quan, MD, MSc
Associate Professor of Surgery and Oncology
Director, Calgary Breast Program
 
Title:  From Scalpel to Swiss Army Knife:  Improving breast cancer care in the 21st century. 

Ben Alman Research Rounds
Friday, January 6, 2017
Topic:  Regenerative Medicine and Soft Tissue Engineering
Speakers:  Dr. Gordon Keller
Director, McEwen Centre for Regenerative Medicine, UHN 
and
Dr. Saeid Amini-Nik
Assistant Professor, Department of Surgery, University of Toronto
and Junior Scientist, Sunnybrook Research Institute
Sunnybrook's Trauma, Emergency & Critical Care (TECC) Program
 
40th Division of General Surgery Annual Assembly
May 25, 2017
Park Hyatt Hotel

RECENT EVENTS 

Faculty Development Day 
This was held on November 11th, 2016 at 89 Chestnut Residence and Conference Centre.
 
 
RECENT EVENTS 
 
Department of Surgery Rounds

Presentations by winners of Lister & George Armstrong-Peter Prizes
Drs. Michael Taylor and Toni Zhong, winners of the Lister & George Armstrong-Peter Prizes, presented talks on "Heterogeneity Through Space and Time Drive the Clinical Behaviour of Childhood Medulloblastoma”; and “Improving the quality of post mastectomy breast reconstruction" on Friday, November 4, 2016 at SickKids.  Left to right: M. Taylor, T. Zhong, J. Rutka.
 
 
Inaugural University of Toronto Global Surgery Journal Club
The first Global Surgery Journal Club was held on Tuesday, November 1st at the home of Dr. James and Mari Rutka.  Some 18 medical students, residents, fellows and faculty were in attendance.  Articles from the recent Lancet Commission on Global Surgery were discussed.

 
NEWSWORTHY ITEMS

Dr. Steven Gallinger (General Surgery) and his collaborators have recently published their important recent research work on the genomics of pancreatic cancer evolution in the journal Nature.  Congratulations to Steve and colleagues on this outstanding achievement!

A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns.  Notta F, Chan-Seng-Yue M, Lemire M, Li Y, Wilson GW, Connor AA, Denroche RE, Liang S-B, Brown AMK, Kim JC, Wang T, Simpson JT, Beck T, Borgida A, Buchner N, Chadwick D, Hafezi-Bakhtiari S, Dick JE, Heisler L, Hollingsworth MA, Ibrahimov E, Jang GH, Johns J, Jorgensen LGT, Law C, Ludkovski O, Lungu I, Ng K, Pasternack D, Petersen GM, Shlush LI, Timms L, Tsao M-S, Wilson JM, Yung CK, Zogopoulos G, Bartlett JMS, Alexandrov, Real FX, Cleary SP, Roehrl MH, McPherson JD, Stein LD, Hudson TJ, Campbell PJ, Gallinger S.  Nature.  2016 Oct 20; 538:378–382.

Kim Tsoi (Orthopaedic Resident) published work from her PhD in Nature Materials on the role of hepatic clearance of nanoparticles.  Congratulations Kim!

Tsoi KM, MacParland SA, Ma XZ, Spetzler VN, Echeverri J, Ouyang B, Fadel SM, Sykes EA, Goldaracena N, Kaths JM, Conneely JB, Alman BA, Selzner M, Ostrowski MA, Adeyi OA, Zilman A, McGilvray ID, Chan WC.  Mechanism of hard-nanomaterial clearance by the liver.  Nat Mater. 2016 Nov;15(11):1212-1221.

Charles H. Tator and Barbara Turnbull Symposium
November 18, 2016
UHN BMO Education and Conference Centre at the Krembil Discovery Tower
Keynote Speaker:  Prof Claes Hultling, MD, PhD, Karolinska Institute
12:15 p.m. – 5:45 p.m.
 
This year marked the 15th anniversary of the Tator-Turnbull Lectureship in Spinal Cord Injury. It was a spectacular event with close to 200 attendees. It was particularly special as there was a moving tribute to Barbara Turnbull and a dedication of one of the spinal cord injury lab investigator offices (that belonging to Charles Tator) in Barb's name.
 
The lectureship featured Claes Hultling from the Karolinska Institute --Claes is himself a quadriplegic as well as an innovative rehabilitation physician and researcher.
 
Also of note, John Honderich --publisher of the Toronto Star attended the event--as a recognition of Barb's work as a Toronto Star reporter. Several of Barb's colleagues, supporters and family members also attended the event. The lectureship also highlighted the strengths in preclinical and clinical translational research in SCI at UHN and U of T.
 
Drs. Michael Cusimano and Charles Tator (Neurosurgery) were quoted in the following CBC article. 
http://www.cbc.ca/news/health/concussion-hotline-baseline-testing-treatment-industry-for-profit-unregulated-1.3833158
 
Dr. Keith Jarvi (Urology) and his team now have a major licensing agreement with a a US Laboratory covering North America and a large Chinese diagnostics company in China for a marker for the diagnosis of different types of male infertility.   This is a significant accomplishment which is the result of years of laboratory research.  Congratulations Keith!  
 


 
Continuing Appointment Reviews (CARs)
The following Continuing Appointment Reviews (CARs) took place in November under the leadership of Ori Rotstein, Associate Chair, Department of Surgery.   
 
Simon Kelley  joined the Division of Orthopaedics at the Hospital for Sick Children as an Assistant Professor of Surgery at The University of Toronto.  Dr. Kelley received his medical degree from the University of Birmingham,UK in 1997. He undertook his basic surgical training in Leeds, UK then moved to Bristol in South West, UK to join the higher surgical residency training scheme in trauma and orthopaedics.  He then went on to do a  limb reconstruction fellowship at the Royal Children’s Hospital in Melbourne, Australia in 2008 followed by being awarded the first Trans-Canada paediatric orthopaedic fellowship in 2008-2009 at the Hospital for Sick Children, Toronto; Shriner’s Hospital for Children, Montreal and BC Children’s Hospital, Vancouver.  Dr Kelley has won awards for clinical excellence, teaching and research, has presented his research at national and international meetings in North America, Europe and Asia.   He has published research papers on a wide range of topics and has written 7 book chapters.  His areas of clinical interest include congenital limb deficiencies,  skeletal dysplasias, posttraumatic limb deformity,  and  hip dysplasia.  His research is focused around biological approaches to limb regeneration, stem cell technology, and limb deformity analysis. From Left to Right: M. Gargan, S. Kelley, C. Caldarone.
 
 
RECENT TWEETS
Avery Nathens ‏@injurydr Nov 18
Dr Todd Mainprize demonstrating the wonders of @focusultrasound in neurosurgery @UofTSurgery @Sunnybrook @Toddgm

Sunnybrook Hospital ‏@Sunnybrook Nov 17
.@FUSFoundation has recognized Sunnybrook as a Centre of Excellence in focused ultrasound — the first in Canada: http://sunnybrook.ca/news/fus 
This technology is revolutionizing how clinicians battle dozens of diseases
See how focused ultrasound works and learn about research underway to test its use for conditions including Alzheimer's disease, brain tumours and obsessive-compulsive disorder
 
SickKids_TheHospital ‏@SickKidsNews Nov 15
A team approach: SickKids & @PMunkCardiacCtr doctors collaborate on high-risk surgery to save an 8-year-old's life http://ow.ly/LWuC306cx7j 
 
Duke Anesthesiology ‏@Duke_Anesthesia Nov 16
This A.M.'s @Duke_Anesthesia #AnesGR featured Dr. Wolfgang Kuebler from @UofTSurgery @StMikesHospital @ChariteBerlin http://www.physiology.utoronto.ca/content/wolfgang-kuebler 
 
UofT Dept of Surgery ‏@UofTSurgery Nov 16
At the Controversies in Neurosurgery meeting hosted by Dr Andrew Kaye at the Royal Melbourne Hospital in Melbourne Australia now!

UofT Vascular ‏@UofTVascular Nov 14
UofT Vascular Retweeted Mohamad A Hussain MD
Great work @ma_hussainMD @StMikesHospital @UofTSurgery
Mohamad A Hussain MD @ma_hussainMD
Decline of #carotid surgery & rise of stenting vs RCTs @StrokeAHA_ASA @UofTVascular @ICESOntario @PSIFoundation http://stroke.ahajournals.org/content/early/2016/11/10/STROKEAHA.116.014856 
 
UofT Dept of Surgery ‏@UofTSurgery Nov 11
Georges Azzie presents concepts on the need for scholarly activities in Global Surgery today at Faculty Development Day now!
 
UofT Dept of Surgery ‏@UofTSurgery Nov 11
Dr Phil Starr seen with neurosurgery residents at the BMO facility at TWH!
 
UofT Dept of Surgery ‏@UofTSurgery Nov 11
Celebrating the Botterell lectureship at TWH with guest invited professor Dr Phil Starr from UCSF!
 
Allan Okrainec ‏@allanokrainec Nov 11
Great session on Competency Based Med Ed @UofTSurgery and Anesthesia Faculty Dev Day-time to bring it on in Gen Surg
 
joanna g. ‏@joannagiddens Nov 10
@UofTSurgery's Dr. Rezende-Neto uses 3D printing to develop prototypes for surgical tools: http://bit.ly/2eWgl5b  #surgery #innovation

Thoracic Surgeons ‏@STS_CTsurgery Nov 10
Dr Chris Caldarone (Toronto) was inaugural Sidney Levitsky Visiting Professor in Cardiac Surgery honoring an STS Past Pres @SickKidsNews
 
UofT Dept of Surgery ‏@UofTSurgery Nov 11
Markku Nousiainen from Orthopedics speaks about the competency based curriculum that was established several years ago!
 
UofT Dept of Surgery ‏@UofTSurgery Nov 11
A whole morning session on competency based medical education at faculty development day for surgery and anesthesia at UofT now!
Today's @globeandmail w/ stories abt @OuzounianMD @UofTVascular @hearthealthydoc @UofTSurgery @uoftmedicine @tedrogersresearch #pmccmagazine
 
Avery Nathens ‏@injurydr Nov 6
Great discussion on role of neurosurgeons for TBI given workforce challenges #tqip2016

James Byrne ‏@DctrJPByrne Nov 5
Avery Nathens (@injurydr) welcomes #TQIP2016. Such a great mentor, leading by example. @UofTSurgery @UofTTrauma @Sunnybrook @ACSTrauma
 
UofT Dept of Surgery ‏@UofTSurgery Nov 4
excellent talks this am from T.@DrToniZhong &M.Taylor, George Armstrong-Peters&Lister Prize presentations @UofTSurgery
 
HONOURS AND AWARDS
       
Dr. Benard Langer (Professor Emeritus, General Surgery) received a Lifetime Achievement Award on November 3rd, 2016 from the University of Toronto.  This award recognizes alumni whose outstanding career achievements have earned them national or international prominence in research, teaching, clinical care, administration or public service.

Dr. Langer is a former Chair of the Department of Surgery.  He is known for developing liver transplantation fellowships and creating the Faculty of Medicine’s acclaimed Surgeon Scientist Training Program, which allows surgical trainees to engage in research in addition to their technical education, encouraging them to use new insights to advance clinical care. 

http://medicine.utoronto.ca/news/surgeon-scientists-balance-and-volunteerism-dean-s-alumni-awards-2016

Congratulations Bernie.  Well deserved!

Paul Kuzyk (Orthopaedics) received the University Divisional Junior Faculty Research Award at the Annual Orthopaedic Research Day November 29, 2016.  Left to right:  P. Ferguson, P. Kuzyk, A. Yee
 



HIGH IMPACT PAPERS HOT OFF THE PRESS
 
Akbari P, Waldman SD, Cushing SL, Papsin BC, Propst EJ, Weber JF, Yeger H, Farhat WA.  Bioengineering pediatric scaffold-free auricular cartilaginous constructs.  Laryngoscope. 2016 Nov 21.

Alimova I, Ng J, Harris P, Birks D, Donson A, Taylor MD, Foreman NK, Venkataraman S, Vibhakar R.  MPS1 kinase as a potential therapeutic target in medulloblastoma.  Oncol Rep. 2016 Nov;36(5):2633-2640.

Alli S, Isik S, Rutka JT.  Microsurgical removal of craniopharyngioma: endoscopic and transcranial techniques for complication avoidance.  J Neurooncol. 2016 Nov;130(2):299-307. Review.

Au K, Bharadwaj S, Venkatraghavan L, Bernstein M.  Outpatient brain tumor craniotomy under general anesthesia.  J Neurosurg. 2016 Nov;125(5):1130-1135.

Avey MT, Moher D, Sullivan KJ, Fergusson D, Griffin G, Grimshaw JM, Hutton B, Lalu MM, Macleod M, Marshall J, Mei SH, Rudnicki M, Stewart DJ, Turgeon AF, McIntyre L; Canadian Critical Care Translational Biology Group.  The Devil Is in the Details: Incomplete Reporting in Preclinical Animal Research.  PLoS One. 2016 Nov 17;11(11):e0166733.

Ayling OG, Ibrahim GM, Alotaibi NM, Gooderham PA, Macdonald RL.  Dissociation of Early and Delayed Cerebral Infarction After Aneurysmal Subarachnoid Hemorrhage.  Stroke. 2016 Nov 8.

Baltzer HL, Moran SL.  The Biomechanical Impact of Digital Loss and Fusion Following Trauma: Setting the Patient up for Success.  Hand Clin. 2016 Nov;32(4):443-463.

Bassett EA, Tokarew N, Allemano EA, Mazerolle C, Morin K, Mears AJ, McNeill B, Ringuette R, Campbell C, Smiley S, Pokrajac NT, Dubuc AM, Ramaswamy V, Northcott PA, Remke M, Monnier PP, Potter D, Paes K, Kirkpatrick LL, Coker KJ, Rice DS, Perez-Iratxeta C, Taylor MD, Wallace VA.  Norrin/Frizzled4 signalling in the preneoplastic niche blocks medulloblastoma initiation.  Elife. 2016 Nov 8;5.

Berger-Richardson D, Swallow CJ.  Needle tract seeding after percutaneous biopsy of sarcoma: Risk/benefit considerations.  Cancer. 2016 Nov 2.

Bezjak A, de Perrot M.  Trimodality Approach to Stage IIIA-N2 NSCLC: As Good as It Gets?  J Thorac Oncol. 2016 Nov;11(11):1817-1818.

Bhatt JR, Jewett MA, Richard PO, Kawaguchi S, Timilshina N, Evans A, Alibhai S, Finelli A.  Multilocular Cystic Renal Cell Carcinoma: Pathological T Staging Makes No Difference to Favorable Outcomes and Should be Reclassified.  J Urol. 2016 Nov;196(5):1350-1355.

Bradley CS, Perry DC, Wedge JH, Murnaghan ML, Kelley SP.  Avascular necrosis following closed reduction for treatment of developmental dysplasia of the hip: a systematic review.  J Child Orthop. 2016 Nov 3.

Braga LH, Jegatheeswaran K, McGrath M, Easterbrook B, Rickard M, DeMaria J, Lorenzo AJ.  Cause and Effect versus Confounding: Is There a True Association between Caudal Blocks and Tubularized Incised Plate Repair Complications?  J Urol. 2016 Oct 26.

Chan V, Sahgal A, Egeto P, Schweizer T, Das S.  Incidence of seizure in adult patients with intracranial metastatic disease.  J Neurooncol. 2016 Nov 22.

Cho YB, Laperriere N, Hodaie M, Chung C.  Hybrid isocenter technique for Gamma-Knife Perfexion treatment of trigeminal neuralgia.  Med Dosim. 2016 Winter;41(4):271-276.

Choi S, O'Hare T, Gollish J, Paul JE, Kreder H, Thorpe KE, Katz JD, Mamdani M, Moisiuk P, McCartney CJ.  Optimizing Pain and Rehabilitation After Knee Arthroplasty: A Two-Center, Randomized Trial.  Anesth Analg. 2016 Nov;123(5):1316-1324.

Chrystoja CC, Darling GE, Diamant NE, Kortan PP, Tomlinson GA, Deitel W, Laporte A, Takata J, Urbach DR.  Achalasia-Specific Quality of Life After Pneumatic Dilation or Laparoscopic Heller Myotomy With Partial Fundoplication: A Multicenter, Randomized Clinical Trial.  Am J Gastroenterol. 2016 Nov;111(11):1536-1545.

Cleary SP, Han HS, Yamamoto M, Wakabayashi G, Asbun HJ.  The comparative costs of laparoscopic and open liver resection: a report for the 2nd International Consensus Conference on Laparoscopic Liver Resection.  Surg Endosc. 2016 Nov;30(11):4691-4696.

Cost NG, Ferrer FA, Lorenzo AJ, Shnorhavorian M, Kieran K, Routh JC, Ritchey ML, Ross JH.  A Society for Pediatric Urology Workforce Survey on the Current Perceptions of Oncology Care by Pediatric Urologists: A Report from the Pediatric Urologic Oncology Working Group of the Society for Pediatric Urology.  J Urol. 2016 Nov 9.

D'Abbondanza JA, Ai J, Lass E, Wan H, Brathwaite S, Tso MK, Lee C, Marsden PA, Macdonald RL.  Robust effects of genetic background on responses to subarachnoid hemorrhage in mice.  J Cereb Blood Flow Metab. 2016 Nov;36(11):1942-1954.

Dall'Era MA, Klotz L.  Active surveillance for intermediate-risk prostate cancer.  Prostate Cancer Prostatic Dis. 2016 Nov 1.

Fernández N, Pérez J, Monterrey P, Poletta FA, Bägli DJ, Lorenzo AJ, Zarante I.  ECLAMC Study: Prevalence patterns of hypospadias in South America: Multi-national analysis over a 24-year period.  Int Braz J Urol. 2016 Nov 2.

Gordon T, de Zepetnek JE.  Motor unit and muscle fiber type grouping after peripheral nerve injury in the rat.  Exp Neurol. 2016 Nov;285(Pt A):24-40.

Hamel W, Köppen JA, Alesch F, Antonini A, Barcia JA, Bergman H, Chabardes S, Contarino MF, Cornu P, Demmel W, Deuschl G, Fasano A, Kühn AA, Limousin P, McIntyre CC, Mehdorn HM, Pilleri M, Pollak P, Rodríguez-Oroz MC, Rumià J, Samuel M, Timmermann L, Valldeoriola F, Vesper J, Visser-Vandewalle V, Volkmann J, Lozano AM.  Targeting of the subthalamic nucleus for deep brain stimulation: a survey among Parkinson's disease specialists.  World Neurosurg. 2016 Nov 9.

He F, Akbari P, Mo R, Zhang JJ, Hui CC, Kim PC, Farhat WA.  Adult Gli2+/-;Gli3Δ699/+ Male and Female Mice Display a Spectrum of Genital Malformation.  PLoS One. 2016 Nov 4;11(11):e0165958.

Hiploylee C, Dufort P, Davis H, Wennberg R, Tartaglia C, Mikulis D, Hazrati LN, Tator C.  Longitudinal Study of Postconcussion Syndrome: Not Everyone Recovers.  J Neurotrauma. 2016 Oct 26.

Hussain MA, Mamdani M, Tu JV, Saposnik G, Khoushhal Z, Aljabri B, Verma S, Al-Omran M.  Impact of Clinical Trial Results on the Temporal Trends of Carotid Endarterectomy and Stenting From 2002 to 2014.  Stroke. 2016 Nov 10.

Jain A, Sponseller PD, Shah SA, Samdani A, Cahill PJ, Yaszay B, Njoku DB, Abel MF, Newton PO, Marks MC, Narayanan UG; Harms Study Group.  Subclassification of GMFCS Level-5 Cerebral Palsy as a Predictor of Complications and Health-Related Quality of Life After Spinal Arthrodesis.  J Bone Joint Surg Am. 2016 Nov 2;98(21):1821-1828.

Karnezis TT, Baker AB, Soler ZM, Wise SK, Rereddy SK, Patel ZM, Oyesiku NM, DelGaudio JM, Hadjipanayis CG, Woodworth BA, Riley KO, Lee J, Cusimano MD, Govindaraj S, Psaltis A, Wormald PJ, Santoreneos S, Sindwani R, Trosman S, Stokken JK, Woodard TD, Recinos PF, Vandergrift WA 3rd, Schlosser RJ.  Factors impacting cerebrospinal fluid leak rates in endoscopic sellar surgery.  Int Forum Allergy Rhinol. 2016 Nov;6(11):1117-1125.

Kato T, Lee D, Wu L, Patel P, Young AJ, Wada H, Hu HP, Ujiie H, Kaji M, Kano S, Matsuge S, Domen H, Kanno H, Hatanaka Y, Hatanaka KC, Kaga K, Matsui Y, Matsuno Y, De Perrot M, Yasufuku K.  SORORIN and PLK1 as potential therapeutic targets in malignant pleural mesothelioma.  Int J Oncol. 2016 Nov 10.

Kestle JR, Kulkarni AV, Warf BC.  Introduction: Pediatric hydrocephalus: a continuing evolution in our understanding and management.  Neurosurg Focus. 2016 Nov;41(5):E1.

Kim BR, Van de Laar E, Cabanero M, Tarumi S, Hasenoeder S, Wang D, Virtanen C, Suzuki T, Bandarchi B, Sakashita S, Pham NA, Lee S, Keshavjee S, Waddell TK, Tsao MS, Moghal N.  SOX2 and PI3K Cooperate to Induce and Stabilize a Squamous-Committed Stem Cell Injury State during Lung Squamous Cell Carcinoma Pathogenesis.  PLoS Biol. 2016 Nov 23;14(11):e1002581.

Kim J, Schweizer TA, Fischer CE, Munoz DG.  The Role of Cerebrovascular Disease on Cognitive and Functional Status and Psychosis in Severe Alzheimer's Disease.  J Alzheimers Dis. 2016 Nov 1;55(1):381-389.

Krishna V, Sammartino F, Yee P, Mikulis D, Walker M, Elias G, Hodaie M.  Diffusion tensor imaging assessment of microstructural brainstem integrity in Chiari malformation Type I.  J Neurosurg. 2016 Nov;125(5):1112-1119.

Kroft J, Ordon M, Po L, Zwingerman N, Lee JY, Pittini R.  Can Surgical "Warm-Up" With Instructor Feedback Improve Operative Performance of Surgical Trainees?  J Minim Invasive Gynecol. 2015 Nov-Dec;22(6S):S17-S18.

Lalu MM, Sullivan KJ, Mei SH, Moher D, Straus A, Fergusson DA, Stewart DJ, Jazi M, MacLeod M, Winston B, Marshall J, Hutton B, Walley KR, McIntyre L.  Evaluating mesenchymal stem cell therapy for sepsis with preclinical meta-analyses prior to initiating a first-in-human trial.  Elife. 2016 Nov 17;5.

Li L, Velumian AA, Samoilova M, Fehlings MG.  A Novel Approach for Studying the Physiology and Pathophysiology of Myelinated and Non-Myelinated Axons in the CNS White Matter.  PLoS One. 2016 Nov 9;11(11):e0165637.

Liu JJ, Matelski J, Cram P, Urbach DR, Bell CM.  Association Between Online Physician Ratings and Cardiac Surgery Mortality.  Circ Cardiovasc Qual Outcomes. 2016 Nov 1.

Lopes RI, Lorenzo AJ.  Reply.  Urology. 2016 Nov 14.

Mäkinen TJ, Fichman SG, Rahman WA, Amenabar T, Safir O, Gross AE, Kuzyk PR.  The focally constrained liner is a reasonable option for revision of unstable total hip arthroplasty.  Int Orthop. 2016 Nov;40(11):2239-2245.

Mathers B, Agur A, Oliver M, Gordon K.  Biaxial quantification of deep layer transverse carpal ligament elastic properties by sex and region.  Clin Biomech (Bristol, Avon). 2016 Oct 27;40:58-62.

Mehta N, Heimbach J, Harnois DM, Sapisochin G, Dodge JL, Lee D, Burns JM, Sanchez W, Greig PD, Grant DR, Roberts JP, Yao FY.  Validation of a Risk Estimation of Tumor Recurrence After Transplant (RETREAT) Score for Hepatocellular Carcinoma Recurrence After Liver Transplant.  JAMA Oncol. 2016 Nov 13.

Michalick L, Erfinanda L, Weichelt U, van der Giet M, Liedtke W, Kuebler WM.  Transient Receptor Potential Vanilloid 4 and Serum Glucocorticoid-regulated Kinase 1 Are Critical Mediators of Lung Injury in Overventilated Mice In Vivo.  Anesthesiology. 2016 Nov 18.

Nagoshi N, Tetreault L, Nakashima H, Nouri A, Fehlings MG.  Return to play in athletes with spinal cord concussion: a systematic literature review.  Spine J. 2016 Nov 8.

Nayan M, Finelli A, Jewett MA, Juurlink DN, Austin PC, Kulkarni GS, Hamilton RJ.  Diabetes and kidney cancer outcomes: a propensity score analysis.  Endocrine. 2016 Nov 4.

Nayan M, Hamilton RJ, Macdonald EM, Li Q, Mamdani MM, Earle CC, Kulkarni GS, Jarvi KA, Juurlink DN; Canadian Drug Safety and Effectiveness Research Network (CDSERN).  Vasectomy and risk of prostate cancer: population based matched cohort study.  BMJ. 2016 Nov 3;355:i5546.

Nayan M, Hamilton RJ.  Reply from Authors re: Peter Albers. Surveillance of Patients with Clinical Stage I Testis Cancer is Safe and Will Remain Unchanged. Eur Urol. In press. http://dx.doi.org/10.1016/j.eururo.2016.10.035.  Eur Urol. 2016 Nov 14.

Nayan M, Macdonald EM, Juurlink DN, Austin PC, Finelli A, Kulkarni GS, Hamilton RJ; Canadian Drug Safety and Effectiveness Research Network (CDSERN).  Medication use and survival in diabetic patients with kidney cancer: A population-based cohort study.  Pharmacol Res. 2016 Nov;113(Pt A):468-474.

Nouri A, Martin A, Tetreault L, Nater A, Kato S, Nakashima H, Nagoshi N, Reihani-Kermani H, Fehlings MG.  MRI analysis of the combined prospectively collected AOSpine North America and International Data: The Prevalence and Spectrum of Pathologies in a Global Cohort of Patients with Degenerative Cervical Myelopathy.  Spine (Phila Pa 1976). 2016 Nov 16.

Okanishi T, Akiyama T, Mayo E, Honda Y, Ueda-Kawada C, Nakajima M, Homma Y, Ochi A, Go C, Widjaja E, Chuang SH, Rutka JT, Drake J, Snead OC 3rd, Otsubo H.  Magnetoencephalography spike sources interrelate the extensive epileptogenic zone of tuberous sclerosis complex.  Epilepsy Res. 2016 Nov;127:302-310.

Pajtler KW, Mack SC, Ramaswamy V, Smith CA, Witt H, Smith A, Hansford JR, von Hoff K, Wright KD, Hwang E, Frappaz D, Kanemura Y, Massimino M, Faure-Conter C, Modena P, Tabori U, Warren KE, Holland EC, Ichimura K, Giangaspero F, Castel D, von Deimling A, Kool M, Dirks PB, Grundy RG, Foreman NK, Gajjar A, Korshunov A, Finlay J, Gilbertson RJ, Ellison DW, Aldape KD, Merchant TE, Bouffet E, Pfister SM, Taylor MD.  The current consensus on the clinical management of intracranial ependymoma and its distinct molecular variants.  Acta Neuropathol. 2016 Nov 17.

Pakdel A, Hardisty M, Fialkov J, Whyne C.  Restoration of Thickness, Density, and Volume for Highly Blurred Thin Cortical Bones in Clinical CT Images.  Ann Biomed Eng. 2016 Nov;44(11):3359-3371.

Penna FJ, Lorenzo AJ, Farhat WA, Butt H, Koyle MA.  Ureteroureterostomy: An Alternative to Ureteroneocystostomy in Select Cases of Pediatric Renal Transplantation.  J Urol. 2016 Nov 14.

Poyet C, Wettstein MS, Lundon DJ, Bhindi B, Kulkarni GS, Saba K, Sulser T, Vickers AJ, Hermanns T.  External Evaluation of a Novel Prostate Cancer Risk Calculator (ProstateCheck) Based on Data from the Swiss Arm of the ERSPC.  J Urol. 2016 Nov;196(5):1402-1407.

Rahman WA, Amenábar T, Hetaimish BM, Safir OA, Kuzyk PR, Gross AE.  Outcome of Revision Total Hip Arthroplasty in Management of Failed Metal-on-Metal Hip Arthroplasty.  J Arthroplasty. 2016 Nov;31(11):2559-2563.

Ramaswamy V, Taylor MD.  Treatment implications of posterior fossa ependymoma subgroups.  Chin J Cancer. 2016 Nov 15;35(1):93.

Redmond KJ, Lo SS, Soltys SG, Yamada Y, Barani IJ, Brown PD, Chang EL, Gerszten PC, Chao ST, Amdur RJ, De Salles AA, Guckenberger M, Teh BS, Sheehan J, Kersh CR, Fehlings MG, Sohn MJ, Chang UK, Ryu S, Gibbs IC, Sahgal A.  Consensus guidelines for postoperative stereotactic body radiation therapy for spinal metastases: results of an international survey.  J Neurosurg Spine. 2016 Nov 11:1-8.

Roberts SL, Burnham RS, Agur AM, Loh EY.  A Cadaveric Study Evaluating the Feasibility of an Ultrasound-Guided Diagnostic Block and Radiofrequency Ablation Technique for Sacroiliac Joint Pain Reg Anesth Pain Med. 2016 Nov 2.

Rodness J, Mihic A, Miyagi Y, Wu J, Weisel RD, Li RK.  VEGF-loaded microsphere patch for local protein delivery to the ischemic heart.  Acta Biomater. 2016 Nov;45:169-181.

Sakuma S, Halliday WC, Nomura R, Baba S, Sato Y, Okanari K, Nakajima M, Widjaja E, Boelman C, Ochi A, Snead OC 3rd, Rutka JT, Drake J, Miller S, Otsubo H.  Increased subcortical oligodendroglia-like cells in pharmacoresistant focal epilepsy in children correlate with extensive epileptogenic zones.  Epilepsia. 2016 Nov 8.

Tam DY, Al-Omran M.  Thoracic outlet syndrome.  CMAJ. 2016 Nov 1;188(16):1179.

Turel MK, Kiehl TR, Gentili F.  Extracranial temporal cavernous hemangioma: Differential diagnosis, and a review of literature.  Neurol India. 2016 Nov-Dec;64(6):1347-1351.

van Wulfften Palthe OD, Janssen SJ, Wunder JS, Ferguson PC, Wei G, Rose PS, Yaszemski MJ, Sim FH, Boland PJ, Healey JH, Hornicek FJ, Schwab JH.  What questionnaires to use when measuring quality of life in sacral tumor patients? The updated sacral tumor survey.  Spine J. 2016 Nov 14.

Wallis CJ, Satkunasivam R, Nam RK.  Postoperative Radiotherapy in Locally Advanced Prostate Cancer: A Question of Who and When.  Eur Urol. 2016 Nov 17.

Walmsley D, Nicayenzi B, Kuzyk PR, Machin A, Bougherara H, Schemitsch EH, Zdero R.  Biomechanical analysis of the cephalomedullary nail versus the trochanteric stabilizing plate for unstable intertrochanteric femur fractures.  Proc Inst Mech Eng H. 2016 Oct 26.

Wang J, Alotaibi NM, Akbar MA, Ayling OG, Ibrahim GM, Macdonald RL; SAHIT collaborators.  Loss of Consciousness at Onset of Aneurysmal Subarachnoid Hemorrhage is Associated with Functional Outcomes in Good-Grade Patients.  World Neurosurg. 2016 Nov 3.

Whitehead WE, Riva-Cambrin J, Kulkarni AV, Wellons JC 3rd, Rozzelle CJ, Tamber MS, Limbrick DD Jr, Browd SR, Naftel RP, Shannon CN, Simon TD, Holubkov R, Illner A, Cochrane DD, Drake JM, Luerssen TG, Oakes WJ, Kestle JR;  for the Hydrocephalus Clinical Research Network.  Ventricular catheter entry site and not catheter tip location predicts shunt survival: a secondary analysis of 3 large pediatric hydrocephalus studies.  J Neurosurg Pediatr. 2016 Nov 4:1-11.

Wong J, Slomovic A, Ibrahim G, Radovanovic I, Tymianski M.  Microsurgery for ARUBA Trial (A Randomized Trial of Unruptured Brain Arteriovenous Malformation)-Eligible Unruptured Brain Arteriovenous Malformations.  Stroke. 2016 Nov 17.

Yanagawa B, Pettersson GB, Habib G, Ruel M, Saposnik G, Latter DA, Verma S.  Surgical Management of Infective Endocarditis Complicated by Embolic Stroke: Practical Recommendations for Clinicians.  Circulation. 2016 Oct 25;134(17):1280-1292.

Yeung JC, Krueger T, Yasufuku K, de Perrot M, Pierre AF, Waddell TK, Singer LG, Keshavjee S, Cypel M.  Outcomes after transplantation of lungs preserved for more than 12 h: a retrospective study.  Lancet Respir Med. 2016 Nov 17.

Younger AS, Glazebrook M, Veljkovic A, Goplen G, Daniels TR, Penner M, Wing KJ, Dryden PJ, Wong H, Lalonde KA.  A Coding System for Reoperations Following Total Ankle Replacement and Ankle Arthrodesis.  Foot Ankle Int. 2016 Nov;37(11):1157-1164.

Zani A, Yeh JB, King SK, Chiu PP, Wales PW.  Duodeno-duodenostomy or duodeno-jejunostomy for duodenal atresia: is one repair better than the other?  Pediatr Surg Int. 2016 Nov 17.
 
Have a new high impact paper in press or published?  Let us know at s.neilson@utoronto.ca
                                                                                                                                                                                                                                                                          






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