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MESSAGE FROM THE CHAIR

Over the holidays, I visited the Parkwood National Historic Site in Oshawa. For those of you who are not familiar with Parkwood, it was the family estate of Robert Samuel (RS) McLaughlin. As many of you are aware, the RS McLaughlin Foundation allocated funds to the Department of Surgery to establish the RS McLaughlin Chair in Surgery which I have the privilege of holding.  What you may not know is that during and after his lifetime, RS McLaughlin (affectionately known as “Sam”) and the McLaughlin Foundation awarded almost $200 million to the University of Toronto to a number of different Departments and Institutes. The McLaughlin Chair in the Department of Surgery was established through the efforts of Dr. DR Wilson when he was Chair of the Department of Surgery (1972-82).  Prior to that, another previous Chair, William Gallie had become friends with Sam and persuaded him to donate funds to establish a traveling fellowship for surgeons at the University of Toronto. Many surgeons from our Faculty have taken full advantage of this opportunity. 
 
I was very fortunate to receive a private tour of the entire estate. I was immediately intrigued with RS McLaughlin’s attention to detail and his clear appreciation of the importance of technologies. The house itself is replete with such examples of “high end” technologies of the day, and many of these were among the first ever in homes and buildings in Canada.   Some of these included a movie theatre, air conditioning units, a quadrophonic stereo system hidden within the bookcases of Sam’s study, and the indoor heated pool. 
 
The McLaughlin family initially made carriages and wagons, but with the onset of the automotive industry, they formed the “McLaughlin Motorcar Company” in 1908.  Sam was President at that time, but it was clear that they were unable to compete with other car companies. Hence, McLaughlin Motor Company was sold, and Sam joined forces with the General Motors Corporation. He became the President of General Motors Company of Canada which was stationed in Oshawa near Parkwood. He was President, from 1918-1945. Following this he remained as Chairman of the Board of General Motors Canada until 1972.  It was clear to me that R.S. McLaughlin was an incredible man with tremendous vision. He was the leader of one of Canada’s most important companies over 30 years. In 1967, Sam was made a Companion of the Order of Canada.
 
It is my great pleasure to review the history of the McLaughlin Estate at Parkwood, and to know a little bit more about the man who has helped the Department of Surgery and many surgeons in so many ways over the years. 
 

Sincerely,  


James T. Rutka, MD, PhD, FRCSC
RS McLaughlin Chair
 

UPCOMING EVENTS

Department of Surgery University Rounds
Kergin Lecture
Friday, February 6, 2015, 7:30 – 8:30 a.m.
Li Ka Shing Auditorium 
St Michael’s Hospital
 
“The Skeptical Scalpel”
 
Department of Surgery Lecture
Balfour Lecture, Thursday, February 12, 2014, 5:00 – 6:00 p.m.
Peter Gilligan Centre (CRL Event Room 1)
Dr. Charles Bosk, PhD, Professor of Sociology, Anesthesia and Critical Care
University of Pennsylvania, Philadelphia, PA
“Mistakes Have Changed: 40 Years of Watching Surgeons Create Accountability”
 
Department of Surgery Hockey Tournament
Sunday, April 12, 2015, 1:00 – 3:00 p.m.
Varsity Arena
If you would like to play, please contact Stephanie at s.neilson@utoronto.ca
 


RECENT EVENTS  

Top to Bottom Campaign for Colon Cancer Canada 
Celebration Event at Edo Restaurant
November 25, 2014
Far left: Bunnie Schwartz (Co-Founder and President) and far right is Amy Elmaleh (Co-Founder and Executive Director) of Colon Cancer Canada.
 

Department of Surgery University Rounds
Ben Alman Research and Science Lecture
Dr. Ben Alman was this year’s Ben Alman Research and Science Lecturer at the Toronto Western Hospital on Friday, January 9, 2014.  The title of his talk was “49”.  From left to right: J. Rutka, B. Alman, M. Fehlings. 
 

Research Strategic Planning Retreat 
January 23, 2015, Chestnut Residence and Conference Centre, University of Toronto.
Under the direction of Michael Fehlings, an all-day research retreat was held to review progress, and provide new directions to the research agenda in the Department of Surgery.



 
NEWSWORTHY ITEMS

In Memoriam
Dr. John Gerald Connolly 
(Surgery Alumnus)
 passed away on December 12, 2014.  John studied Medicine at the University of Toronto receiving his MD in 1949.  After training in Edinburgh, London, New York City,  and Kingston, he returned to Toronto securing an appointment at Women's College Hospital in 1971 and subsequently became cross appointed at Princess Margaret Hospital and the Toronto General Hospital. John was appointed as Associate Surgeon in Chief in the early 80's and stepped up as interim Surgeon in Chief during a period of
turbulence at Women's College Hospital.  Within the Division of Urology at the University of Toronto he is remembered as 'a mentor and an original thinker.'   Even upon retirement his curiosity was relentless. He worked for more than a decade on a series of innovative medical devices. 
 
Dr. Sigmund H. Ein (Surgery Alumnus) passed away on Sunday, January 25, 2015.  Dr. Ein began his career at SickKids on July 1, 1969 in the Division of General Surgery where he remained until his retirement in 2004. During his 35 years at the University of Toronto,  he held many leadership positions within Sick Kids and was President of the Canadian Association of Paediatric Surgeons.  After retirement he remained an Honorary member of staff at SickKids and an Associate Professor of Surgery at the University of Toronto.  Dr Ein was devoted to the children and their families, and his advocacy on their behalf served as a powerful role model for several generations of trainees and colleagues. Dr. Ein was internationally known for promoting and documenting the natural history and non-operative management of a variety of paediatric surgical conditions.  Dr. Ein will be remembered for many things including playing Santa at the annual Perioperative Holiday Grand Rounds at Sick Kids, his “den” (which was an eclectic mix of sporting memorabilia and gifts from patients), and his many “Einisms” as his fellows would call them.  Dr. Ein was a dedicated surgeon, teacher, mentor, husband and father whose signature purple marker will be remembered by everyone who was lucky enough to have met him. 
 
Chris Caldarone (Cardiac Surgery) has been appointed as Surgeon-in-Chief at The Hospital for Sick Children effective immediately.  Chris is presently Chair of the Division of Cardiac Surgery at the University of Toronto and holds the Watson Family Chair in Cardiovascular Sciences.   He became a faculty member at SickKids in 2003.  He is recognized internationally as a clinician, scientist, and scholar.
 



Marc Jeschke (Plastic and Reconstructive Surgery) was featured on the CTV  News At 6, January 6, 2015.  He proudly wore his U. of T. Department of Surgery scrub cap as he discussed how to prevent frost bite.  Marc is the Director of the Ross Tilley Burn Centre at Sunnybrook Health Science Center and a Professor in the Department of Surgery, Department of Immunology and the Institute of Medical Science at UofT. He holds the Chair of Burn Research and is a Senior Scientist at Sunnybrook Research Institute.
 



Continuing Appointment Reviews (CARs)
The following Continuing Appointment Reviews (CARs) took place in January under the leadership of Ori Rotstein, Associate Chair, Department of Surgery.  
 
Girish Kulkarni joined the Division of Urology in 2011 at Sunnybrook Health Sciences Centre as Assistant Professor in the Department of Surgery, University of Toronto.  He completed his medical school and residency in urology at the University of Toronto. During his residency, he entered the Surgeon-Scientist program and completed his PhD in Clinical Epidemiology through the Department of Health Policy, Management and Evaluation at the Institute for Clinical Evaluative Sciences (ICES). He then completed a fellowship in Urologic Oncology at Memorial Sloan-Kettering Cancer Center in New York City. His primary research interests involve the epidemiology of genitourinary malignancies, particularly bladder and prostate cancer.  Left to right:  D. Urbach, N. Fleshner, G. Kulkarni, S. Keshavjee
 
Leonard Tse joined the Division of Vascular Surgery at the Toronto General Hospital and Princess Margaret Cancer Centre at UHN in 2011.  He completed his M.D. degree in 1997 at the University of Toronto; his General Surgery in Toronto; and Vascular Surgery at McGill University in 2004. He practiced vascular surgery in Calgary for 4 years where he served as the Program Director of the University of Calgary Vascular Surgery Residency Training Program. In 2008 he returned to the University of Toronto Institute of Biomaterials and Biomedical Engineering as a full-time graduate student in the MASc program. In 2010 he completed his research thesis and is now an assistant professor in the Department of Surgery at the University of Toronto.  His research interests involve the engineering aspects of minimally-invasive endovascular technology used in vascular surgery, and the use of computational modeling for aortic pathology. In collaboration with the Université de Montreal, he published the world’s first antegrade in-situ fenestration of an aortic stent-graft. Development of the technique of in-situ fenestration has led to further study in materials and collaboration with the NCSU College of Textiles. He implanted North America’s first Fenestrated Anaconda device, and sits on the RCPSC Examination Board in Vascular Surgery.  Left to right:  T. Lindsay, L. Tse, T. Forbes, K. Yasufuku
 
 
RECENT TWEETS
Jan.23
‪@DrFehlings, our Vice Chair of Research at ‪@UofTSurgery, welcomes everyone to the Research Strategic Planning Retreat
 
Jan 23
Chris Caldarone has been appointed Surgeon-in-Chief at SickKids effectively immediately.  Congratulations!
 
Jan 19
Nizar Mahomed in Globe & Mail re health researchers contributing to funding of research studies.  ‪http://www.theglobeandmail.com/life/health-and-fitness/health/health-researchers-digging-into-own-pockets-to-bridge-gap-in-funding/article22513697/ …
 
Jan 13
Michael Jewett has received a CIHR award which was ranked #1 in the competition.  Congratulations!
 
Jan 12
Peter Ferguson has been named the 2015 recipient of the RCPSC/AMS/Donald Richard Wilson Award.  Congratulations!
 
Jan 9
Ben Alman Chair of Orthpaedics at Duke University gives Ben Alman Research Lecture today
 · 
Jan 9
Dept of Surgery rounds today at 7:30 am, TWH. Ben Alman visiting speaker.

 
HONOURS AND AWARDS
 
Peter Ferguson (Orthopaedics) has been named the 2015 recipient of the RCPSC/AMS/Donald Richard Wilson Award.  Recipients of the award are recognized for helping integrate CanMEDS roles into a Royal College or other health-related training program.
 
Ethan Grober (Urology) received a grant from the WCHAMSG Innovation Fund for his project entitled, “Development and Validation of a Competency-Based Program of Education and Assessment of the Fundamentals of Micro Surgery (FMS).”
 
Timothy Jackson (General Surgery) is the 2013-2014 recipient of Continuing Professional Development, Faculty of Medicine's David Fear Fellowship.  This award recognizes and promotes the importance of innovative programs in continuing education for health professionals.
 
Michael Jewett (Urology) is the recipient of an award from the Canadian Institutes of Health Research (CIHR) for his project “Determining the Research Priorities of Canadian Kidney Cancer Patients, Caregivers and Clinicians: A Priority Setting Partnership for Kidney Cancer”.  This award was ranked #1 in the entire competition!
 
Shaf Keshavjee (Thoracic Surgery) has been awarded the Order of Canada (Officer) for his innovative contributions to thoracic surgery.
 
Laurence Klotz (Urology) has been awarded the Order of Canada (Member) for his contributions to the treatment of prostate cancer. 
 
 
HIGH IMPACT PAPERS HOT OFF THE PRESS

Agnihotri S, Aldape KD, Zadeh G. Isocitrate dehydrogenase status and molecular subclasses of glioma and glioblastoma. Neurosurg Focus. 2014 Dec;37(6):E13.
 
Agnihotri S, Gugel I, Remke M, Bornemann A, Pantazis G, Mack SC, Shih D, Singh SK, Sabha N, Taylor MD, Tatagiba M, Zadeh G, Krischek B. Gene-expression profiling elucidates molecular signaling networks that can be therapeutically targeted in vestibular schwannoma. J Neurosurg. 2014 Dec;121(6):1434-45.
 
Akiyama T, Akiyama M, Kobayashi K, Okanishi T, Boelman CG, Nita DA, Ochi A, Go CY, Snead OC 3rd, Rutka JT, Drake JM, Chuang S, Otsubo H.  Spatial relationship between fast and slow components of ictal activities and interictal epileptiform discharges in epileptic spasms.  Clin Neurophysiol. 2014 Dec 15. pii: S1388-2457(14)00849-9. doi: 10.1016/j.clinph.2014.12.005.
 
Anayama T, Qiu J, Chan H, Nakajima T, Weersink R, Daly M, McConnell J, Waddell T, Keshavjee S, Jaffray D, Irish JC, Hirohashi K, Wada H, Orihashi K, Yasufuku K.  Localization of pulmonary nodules using navigation bronchoscope and a near-infrared fluorescence thoracoscope.  Ann Thorac Surg. 2015 Jan;99(1):224-30.
 
Austin RE, Shahrokhi S, Bolourani S, Jeschke MG.  Peripherally inserted central venous catheter safety in burn care: a single-center retrospective cohort review.  J Burn Care Res. 2015 Jan-Feb;36(1):111-7.
 
Barszczyk M, Buczkowicz P, Castelo-Branco P, Mack SC, Ramaswamy V, Mangerel J, Agnihotri S, Remke M, Golbourn B, Pajovic S, Elizabeth C, Yu M, Luu B, Morrison A, Adamski J, Nethery-Brokx K, Li XN, Van Meter T, Dirks PB, Rutka JT, Taylor MD, Tabori U, Hawkins C. Telomerase inhibition abolishes the tumorigenicity of pediatric ependymoma tumor-initiating cells. Acta Neuropathol. 2014 Dec;128(6):863-77.
 
Berger MS, Bruce JN, Chen TC, Zadeh G. Introduction: Glioblastoma: an update on pathophysiology and management strategies. Neurosurg Focus. 2014 Dec;37(6):Introduction.
 
Bogdanovic E, Kraus N, Patsouris D, Diao L, Wang V, Abdullahi A, Jeschke MG.  Endoplasmic reticulum stress in adipose tissue augments lipolysis.  J Cell Mol Med. 2015 Jan;19(1):82-91.
 
Cadotte DW, Cadotte A, Cohen-Adad J, Fleet D, Livne M, Wilson JR, Mikulis D, Nugaeva N, Fehlings MG.  Characterizing the Location of Spinal and Vertebral Levels in the Human Cervical Spinal Cord.  AJNR Am J Neuroradiol. 2014 Dec 18. [Epub ahead of print]
 
Cadotte D, Sedney C, Djimbaye H, Bernstein MA qualitative assessment of the benefits and challenges of international neurosurgical teaching collaboration in Ethiopia. World Neurosurgery 82:980-986, 2014
 
Chen P, Stanojcic M, Jeschke MG.  Differences between murine and human sepsis.  Surg Clin North Am. 2014 Dec;94(6):1135-49.
 
Chen L, Yau I, deVeber G, Dirks P, Armstrong D, Krings T. Evolution of a chronic dissecting aneurysm on magnetic resonance imaging in a pediatric patient. J Neurosurg Pediatr. 2014 Dec 5:1-5. 
 
Cripton PA, Shen H, Brubacher JR, Chipman M, Friedman SM, Harris MA, Winters M, Reynolds CC, Cusimano MD, Babul S, Teschke K.  Severity of urban cycling injuries and the relationship with personal, trip, route and crash characteristics: analyses using four severity metrics.  BMJ Open. 2015 Jan 5;5(1):e006654. doi: 10.1136/bmjopen-2014-006654.
 
D'Angelo K, Kim P, Murnaghan ML.  Juvenile Osteochondritis Dissecans in a 13-year-old male athlete: A case report.  J Can Chiropr Assoc. 2014 Dec;58(4):384-94.
 
David TE.  Aortic valve repair and aortic valve-sparing operations.  J Thorac Cardiovasc Surg. 2015 Jan;149(1):9-11.
 
Deobald RG, Cheng ES, Ko YJ, Wright FC, Karanicolas PJ.  A qualitative study of patient and clinician attitudes regarding surveillance after a resection of pancreatic and peri-ampullary cancer.  HPB (Oxford). 2014 Dec 24. doi: 10.1111/hpb.12378. [Epub ahead of print]
 
Derouet MF, Liu G, Darling GE.  MiR-145 Expression Accelerates Esophageal Adenocarcinoma Progression by Enhancing Cell Invasion and Anoikis Resistance.  PLoS One. 2014 Dec 31;9(12):e115589. doi: 10.1371/journal.pone.0115589. eCollection 2014.
 
Di Ieva A, Boukadoum M, Lahmiri S, Cusimano MD.  Computational Analyses of Arteriovenous Malformations in Neuroimaging.  J Neuroimaging. 2014 Dec 17. doi: 10.1111/jon.12200. [Epub ahead of print]
 
Di Meo A, Rotondo F, Kovacs K, Cusimano MD, Syro LV, Di Ieva A, Diamandis EP, Yousef GM.  Human Kallikrein 10 Expression in Surgically Removed Human Pituitary Corticotroph Adenomas: An Immunohistochemical Study.  Appl Immunohistochem Mol Morphol. 2014 Dec 16. [Epub ahead of print]
 
Donaldson S, Wright JG.  Simple bone cysts: better with age?  J Pediatr Orthop. 2015 Jan;35(1):108-14.
 
Dziedzic T, Bernstein M: Awake craniotomy for brain tumor: Indications, technique, benefits. Expert Reviews in Neurotherapeutics 14:1405-1415, 2014.
 
Eiriksson L, Aronson M, Clarke B, Mojtahedi G, Massey C, Oza AM, Gallinger S, Pollett A, Mackay H, Bernardini MQ, Ferguson SE.  Performance characteristics of a brief Family History Questionnaire to screen for Lynch syndrome in women with newly diagnosed endometrial cancer.  Gynecol Oncol. 2014 Dec 19. pii: S0090-8258(14)01612-6. doi: 10.1016/j.ygyno.2014.12.023.
 
Emami H, Singh P, MacNabb M, Vucic E, Lavender Z, Rudd JH, Fayad ZA, Lehrer-Graiwer J, Korsgren M, Figueroa AL, Fredrickson J, Rubin B, Hoffmann U, Truong QA, Min JK, Baruch A, Nasir K, Nahrendorf M, Tawakol A.  Splenic Metabolic Activity Predicts Risk of Future Cardiovascular Events: Demonstration of a Cardiosplenic Axis in Humans.  JACC Cardiovasc Imaging. 2014 Dec 31. pii: S1936-878X(14)00933-4. doi:
10.1016/j.jcmg.2014.10.009.
 
Faria CC, Golbourn BJ, Dubuc AM, Remke M, Diaz RJ, Agnihotri S, Luck A, Sabha N, Olsen S, Wu X, Garzia L, Ramaswamy V, Mack SC, Wang X, Leadley M, Reynaud D, Ermini L, Post M, Northcott PA, Pfister SM, Croul SE, Kool M, Korshunov A, Smith CA, Taylor MD, Rutka JT.  Foretinib is effective therapy for metastatic sonic hedgehog medulloblastoma.  Cancer Res. 2015 Jan 1;75(1):134-46.
 
Glennie RA, Ailon T, Yung K, Batke J, Vaccaro AR, Fehlings MG, Arnold P, Harrop JS, Street J. Incidence, impact and risk factors of adverse events in thoracic and lumbar spine fractures. An ambispective cohort analysis of 390 patients. Spine J. 2014 Nov 28. pii: S1529-9430(14)01762-8.
 
Grant RC, Selander I, Connor AA, Selvarajah S, Borgida A, Briollais L, Petersen GM, Lerner-Ellis J, Holter S, Gallinger S.  Prevalence of Germline Mutations in Cancer Predisposition Genes in Patients With Pancreatic Cancer.  Gastroenterology. 2014 Dec 2. pii: S0016-5085(14)01479-6. doi: 10.1053/j.gastro.2014.11.042. [Epub ahead of print]
 
Guo J, Zhang Y, Mihic A, Li SH, Sun Z, Shao Z, Wu J, Weisel RD, Li RK.  A Secreted Protein (Canopy 2, CNPY2) Enhances Angiogenesis and Promotes Smooth Muscle Cell Migration and Proliferation.  Cardiovasc Res. 2015 Jan 14. pii: cvv010.
 
Hussain MA, Lindsay TF, Tan KT, Moloney T.  Coil embolization of the false lumen in complicated type B aortic dissection.  Ann Vasc Surg. 2015 Jan;29(1):125.e13-7. doi: 10.1016/j.avsg.2014.07.041. Epub 2014 Oct 7.
 
Jaja BN, Attalla D, Macdonald RL, Schweizer TA, Cusimano MD, Etminan N, Hanggi D, Hasan D, Johnston SC, Le Roux P, Lo B, Louffat-Olivares A, Mayer S, Molyneux A, Noble A, Quinn A, Schenk T, Spears J, Singh J, Todd M, Torner J, Tseng M, van den Bergh W, Vergouwen MD, Wong GK. The Subarachnoid Hemorrhage International Trialists (SAHIT) Repository: Advancing Clinical Research in Subarachnoid Hemorrhage. Neurocrit Care. 2014 Dec;21(3):551-9.
 
Jeschke MG, Pinto R, Kraft R, Nathens AB, Finnerty CC, Gamelli RL, Gibran NS, Klein MB, Arnoldo BD, Tompkins RG, Herndon DN; the Inflammation and the Host Response to Injury Collaborative Research Program.  Morbidity and Survival Probability in Burn Patients in Modern Burn Care.  Crit Care Med. 2014 Dec 31.
 
Kader AK, Liss MA, Xu J, Fleshner NE.  Reply.  Urology. 2015 Jan;85(1):171.
 
Kader AK, Liss MA, Trottier G, Kim ST, Sun J, Zheng SL, Chadwick K, Lockwood G, Xu J, Fleshner NE.  Impact of Prostate-specific Antigen on a Baseline Prostate Cancer Risk Assessment Including Genetic Risk.  Urology. 2015 Jan;85(1):165-71.
 
Khella HW, Scorilas A, Mozes R, Mirham L, Lianidou E, Krylov SN, Lee JY, Ordon M, Stewart R, Jewett MA, Yousef GM.  Low Expression of miR-126 Is a Prognostic Marker for Metastatic Clear Cell Renal Cell Carcinoma.  Am J Pathol. 2015 Jan 5. pii: S0002-9440(14)00687-7. doi: 10.1016/j.ajpath.2014.11.017.
 
Kidane B, Darling GE.  Improving decision-making regarding oesophagectomy after preoperative therapy.  Eur J Cardiothorac Surg. 2015 Jan 5. pii: ezu486. [Epub ahead of print] No abstract available.
 
Kotha VK, Yan AT, Prabhudesai V, Kirpalani A, Connelly K, Peerani R, Hill SJ, Streutker CJ, Latter DA, Pinter A, Deva DP.  Benign intramyocardial mesothelial cyst in the right ventricular outflow tract: computed tomography and cardiovascular magnetic resonance imaging appearances.  Circulation. 2014 Dec 9;130(24):e275-7. doi: 10.1161/CIRCULATIONAHA.114.009658.
 
Kucyi A, Davis KD.  The dynamic pain connectome.  Trends Neurosci. 2014 Dec 22. pii: S0166-2236(14)00217-3. doi: 10.1016/j.tins.2014.11.006. Review.
 
Kwan BY, Krings T, Bernstein M, Mandell DM.  A novel mechanism of toxic injury to the Papez circuit from chemotherapy.  J Clin Neurosci. 2015 Jan 3. pii: S0967-5868(14)00659-6. doi: 10.1016/j.jocn.2014.10.008.
 
Macdonald RL, Diringer MN, Citerio G. Understanding the disease: aneurysmal subarachnoid hemorrhage. Intensive Care Med. 2014 Dec;40(12):1940-3.
 
Mangerel J, Price A, Castelo-Branco P, Brzezinski J, Buczkowicz P, Rakopoulos P, Merino D, Baskin B, Wasserman J, Mistry M, Barszczyk M, Picard D, Mack S, Remke M, Starkman H, Elizabeth C, Zhang C, Alon N, Lees J, Andrulis IL, Wunder JS, Jabado N, Johnston DL, Rutka JT, Dirks PB, Bouffet E, Taylor MD, Huang A, Malkin D, Hawkins C, Tabori U. Alternative lengthening of telomeres is enriched in, and impacts survival of TP53 mutant pediatric malignant brain tumors. Acta Neuropathol. 2014 Dec;128(6):853-62.
 
Mansouri A, Guha D, Klironomos G, Larjani S, Zadeh G, Kondziolka D.  Stereotactic Radiosurgery for Intracranial Meningiomas: Current Concepts and Future Perspectives.  Neurosurgery. 2015 Jan 16.
  
Mayne IP, Wasserstein D, Modi CS, Henry PD, Mahomed N, Veillette C.  The epidemiology of closed reduction for simple elbow dislocations and the incidence of early subsequent open reduction.  J Shoulder Elbow Surg. 2015 Jan;24(1):83-90.
 
Metcalfe KA, Zhong T, Narod SA, Quan ML, Holloway C, Hofer S, Bagher S, Semple J.  A prospective study of mastectomy patients with and without delayed breast reconstruction: Long-term psychosocial functioning in the breast cancer survivorship period.  J Surg Oncol. 2014 Dec 29. doi: 10.1002/jso.23829.
 
Meyer M, Reimand J, Lan X, Head R, Zhu X, Kushida M, Bayani J, Pressey JC, Lionel AC, Clarke ID, Cusimano M, Squire JA, Scherer SW, Bernstein M, Woodin MA, Bader GD, Dirks PB.  Single cell-derived clonal analysis of human glioblastoma links functional and genomic heterogeneity.  Proc Natl Acad Sci U S A. 2015 Jan 20;112(3):851-6.
 
Nikolaev S, Santoni F, Garieri M, Makrythanasis P, Falconnet E, Guipponi M, Vannier A, Radovanovic I, Bena F, Forestier F, Schaller K, Dutoit V, Clement-Schatlo V, Dietrich PY, Antonarakis SE. Extrachromosomal driver mutations in glioblastoma and low-grade glioma. Nat Commun. 2014 Dec 4;5:5690. 
 
Okumura K, Kato H, Honjo O, Breitling S, Kuebler WM, Sun M, Friedberg MK.  Carvedilol improves biventricular fibrosis and function in experimental pulmonary hypertension.  J Mol Med (Berl). 2015 Jan 18.
 
Olsen M, Al Saied M, Morison Z, Sellan M, Waddell JP, Schemitsch EH.  The impact of proximal femoral morphology on failure strength with a mid-head resection short-stem hip arthroplasty.  Proc Inst Mech Eng H. 2014 Dec;228(12):1275-80.
 
Panchapakesan V, Zhong T, Forrest CR, Pusic AL, Thoma A.  Psychometrics: Essential for Valid, Reliable, and Responsive Measurement in the Development of Patient-reported Outcome Instruments in Plastic Surgery.  Plast Reconstr Surg Glob Open. 2015 Jan 8;2(12):e280. doi: 10.1097/GOX.0000000000000197. eCollection 2014 Dec.
 
Rafay MF, Armstrong D, Dirks P, MacGregor DL, deVeber G.  Patterns of cerebral ischemia in children with moyamoya.  Pediatr Neurol. 2015 Jan;52(1):65-72.
 
Rahkonen O, Chaturvedi RR, Benson L, Honjo O, Caldarone CA, Lee KJ.  Pulmonary artery stenosis in hybrid single-ventricle palliation: High incidence of left pulmonary artery intervention.  J Thorac Cardiovasc Surg. 2014 Dec 3. pii: S0022-5223(14)01997-7. doi: 10.1016/j.jtcvs.2014.11.080.
 
Ramaswamy V, Remke M, Adamski J, Bartels U, Tabori U, Wang X, Huang A, Hawkins C, Mabbott D, Laperriere N, Taylor MD, Bouffet E.  Medulloblastoma subgroup-specific outcomes in irradiated children: who are the true high-risk patients?  Neuro Oncol. 2015 Jan 20. pii: nou357.
 
Ramaswamy V, Remke M, Taylor MD. An epigenetic therapy for diffuse intrinsic pontine gliomas. Nat Med. 2014 Dec 4;20(12):1378-9.
 
Ravishankar N, Bernstein M. Religion benefiting brain tumour patients: a qualitative study. J Relig Health. 2014 Dec;53(6):1898-906.
 
Reznikov R, Diwan M, Nobrega JN, Hamani C.  Towards a better preclinical model of PTSD: Characterizing animals with weak extinction, maladaptive stress responses and low plasma corticosterone.  J Psychiatr Res. 2014 Dec 26. pii: S0022-3956(14)00358-6. doi: 10.1016/j.jpsychires.2014.12.017.
 
Rusert JM, Wu X, Eberhart CG, Taylor MD, Wechsler-Reya RJ.  SnapShot: Medulloblastoma.  Cancer Cell. 2014 Dec 8;26(6):940-940.e1. doi: 10.1016/j.ccell.2014.11.015.
 
Rutka JT.  Editorial: A new look for JNSPG publications: the anatomy of redesign.
J Neurosurg. 2015 Jan;122(1):1-3. doi: 10.3171/2014.9.JNS142259.
 
Sahgal A, Chan MW, Atenafu EG, Masson-Cote L, Bahl G, Yu E, Millar BA, Chung C, Catton C, O'Sullivan B, Irish JC, Gilbert R, Zadeh G, Cusimano M, Gentili F, Laperriere NJ.  Image-guided intensity modulated radiation therapy (IG-IMRT) for skull base chordoma and chondrosarcoma: preliminary outcomes.  Neuro Oncol. 2014 Dec 27. pii: nou347.
 
Saleh F, Abbasi TA, Cleghorn M, Jimenez MC, Jackson TD, Okrainec A, Quereshy FA.  Preoperative endoscopy localization error rate in patients with colorectal cancer.  Surg Endosc. 2014 Dec 6.
 
Seemann NM, Elkadri A, Walters TD, Langer JC.  The role of surgery for children with perianal Crohn's disease.  J Pediatr Surg. 2015 Jan;50(1):140-3.
 
Sidorova-Darmos E, Wither RG, Shulyakova N, Fisher C, Ratnam M, Aarts M, Lilge L, Monnier PP, Eubanks JH.  Differential expression of sirtuin family members in the developing, adult, and aged rat brain.  Front Aging Neurosci. 2014 Dec 18;6:333.
 
Slow EJ, Hamani C, Lozano AM, Poon YY, Moro E.  Deep brain stimulation for treatment of dystonia secondary to stroke or trauma.  J Neurol Neurosurg Psychiatry. 2014 Dec 22. pii: jnnp-2014-308943. doi: 10.1136/jnnp-2014-308943.
 
Somogyi RB, Brown MH.  Outcomes in Primary Breast Augmentation: A Single Surgeon's Review of 1539 Consecutive Cases.  Plast Reconstr Surg. 2015 Jan;135(1):87-97.
 
Sternheim A, Daly M, Qiu J, Weersink R, Chan H, Jaffray D, Irish JC, Ferguson PC, Wunder JS.  Navigated pelvic osteotomy and tumor resection: a study assessing the accuracy and reproducibility of resection planes in sawbones and cadavers.  J Bone Joint Surg Am. 2015 Jan 7;97(1):40-6. doi: 10.2106/JBJS.N.00276.
 
Strickland M, Hallet J, Abramowitz D, Liang S, Law CH, Jayaraman S.  Lateral approach in laparoscopic distal pancreatectomy is safe and potentially beneficial compared to the traditional medial approach.  Surg Endosc. 2014 Dec 6.
 
Touil L, Fisher DM, Fattah AY.  Re: "Assessment of long-term donor-site morbidity after harvesting the latissimus dorsi flap for neonatal myelomeningocele repair."  J Plast Reconstr Aesthet Surg. 2015 Jan 9. pii: S1748-6815(14)00739-6. doi: 10.1016/j.bjps.2014.12.037.
 
Trudeau MO, Nasr A, Carrillo B, Gerstle JT, Azzie G.  Construct validity and educational role for motion analysis in a laparoscopic trainer.  Surg Endosc. 2014 Dec 6.
 
Tsang DS, Khan L, Perry JR, Soliman H, Sahgal A, Keith JL, Mainprize TG, Das S, Zhang L, Tsao MN.  Survival Outcomes in Elderly Patients with Glioblastoma.  Clin Oncol (R Coll Radiol). 2014 Dec 27. pii: S0936-6555(14)00442-7. doi: 10.1016/j.clon.2014.11.026.
 
Vasheghani F, Zhang Y, Li YH, Blati M, Fahmi H, Lussier B, Roughley P, Lagares D, Endisha H, Saffar B, Lajeunesse D, Marshall WK, Rampersaud YR, Mahomed NN, Gandhi R, Pelletier JP, Martel-Pelletier J, Kapoor M.  PPARγ deficiency results in severe, accelerated osteoarthritis associated with aberrant mTOR signalling in the articular cartilage.  Ann Rheum Dis. 2015 Jan 8. pii: annrheumdis-2014-205743. doi: 10.1136/annrheumdis-2014-205743.
 
Wada H, Hirohashi K, Nakajima T, Anayama T, Kato T, Grindlay A, McConnell J, Yoshino I, Yasufuku K.  Assessment of the new thin convex probe endobronchial ultrasound bronchoscope and the dedicated aspiration needle: a preliminary study in the porcine lung.  J Bronchology Interv Pulmonol. 2015 Jan;22(1):20-7.
 
Walmsley D, Axelrod T, Rodriguez-Elizalde S.  Compartment Syndrome following Open Femoral Fracture with an Isolated Femoral Vein Injury Treated with Acute Repair.  Case Rep Orthop. 2014;2014:502657. doi: 10.1155/2014/502657. Epub 2014 Dec 22.
 
Westwick HJ, Yuh SJ, Shamji MF.  Complication Avoidance in the Resection of Spinal Meningiomas.  World Neurosurg. 2014 Dec 17. pii: S1878-8750(14)01386-2. doi: 10.1016/j.wneu.2014.12.015. [Epub ahead of print] Review.
 
Witiw CD, Shamji MF. Brown-Séquard syndrome from herniation of a thoracic disc. CMAJ. 2014 Dec 9;186(18):1395.
 
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