~ January 2019 Newsletter ~

Happy New Year!

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The Gut: A Window Into Your Health 

Conventional Medicine is great at diagnosing different diseases based on symptomology and objective findings, however, actual cures to chronic illness are hard to come by; we typically only receive treatments that help “manage” our diseases and potentially decrease the symptoms.  This is mostly true because the investigation seems to stop once the disease has been officially diagnosed.  I cannot tell you how many patients I have seen that show up with the remark “ I was told I have “X” but there are really no great treatment options…. Now what?” 
The disease diagnosis in actuality opens a whole other door of investigations.  The “Why” do I have Crohn’s disease or Rheumatoid arthritis and the “Why” do I have high blood pressure or cannot lose weight are still questions that should be and are usually lingering within the patient’s thoughts.  Most of the time we get the ‘well it runs in your family’ or ‘bad luck’ or ‘we do not know’ answers, mostly because in all honestly we do not know….yet.  The current practice of medicine focuses on treatments that have typically been scientifically proven to help the disease symptoms.  This is not necessarily a bad idea but often causes are not proven because they are way too complex.

It Is completely asinine to think that there is only one cause to incredibly complex disease processes and according to modern scientific research only 1 variable can be investigated at a time and proving causation will be very difficult if not looking at how all of the potential variables work together to create the dis-ease.  It is kind of a perfect storm of variables that create disease and often the variables are different in 2 people with the same diagnosed disease.   This is not easy to understand even for the most medically trained professionals. This is the art of medicine that has slowly been dwindling.  Paracelsus, the pioneer of the medical revolution once said “Medicine is not only a science; it is also an art. It does not consist of compounding pills and plasters; it deals with the very processes of life, which must be understood before they may be guided.”
It comes down to the fact that many factors can interfere with proper function of the body. This is why it is important to take that holistic or whole person view of the situation.  Often times people have different forces coming at them from different directions (physical, emotional, genetics) and usually there is also a domino effect of events that leads to dis-ease in the body – for ex. I have been eating a diet high in fast food and soda and developed reflux, then I started reflux medications which then led to mineral deficiencies and constipation, which then led to irregular menses and use of birth control pills, which then caused more gastrointestinal problems leading to small intestinal bowel overgrowth and worsened reflux …. Whew! I am sure you get the picture.  
Figuring out this puzzle and looking more closely into how the body is functioning is how Naturopathic physicians are trained.  One of the first places we start investigating in the majority of disease processes is the Gastrointestinal (GI) tract or as we call it “The Gut”.  Many disease processes do in fact begin within the GI tract even when the result of the dis-ease promotes zero gastrointestinal symptoms. 
So what exactly is going on the gut?   Well, we all eat and we all know that we cannot live without food.  Food gives us most everything our bodies need to function properly.  Most of us know this but most have no clue how all this happens.  It’s quite miraculous actually.  There is so much more however going on in the gut than just digestion and absorption of nutrients.  The majority of our immune cells are produced in the GI lining, thyroid hormone is activated, neurotransmitters are produced, vitamin A in converted from beta carotene, vitamin K is produced and so much more! There is such an intricate systematic process required for this all to be successful. 

The GI tract requires proper mucous, acid and hormone production to work as well as the help of billions of bacteria and other microbes.  If any of this is impaired and the gastrointestinal lining becomes damaged, the result is inflammation.  And with excessive inflammation comes hormone and neurotransmitter imbalances, recirculating bio toxins and environmental toxicants which all only causes a domino effect of more problems.   Inflammation is a word thrown around a lot by medical professionals but it is extremely complicated.  It involves dozens of cell types and signaling molecules all of which communicate in immensely complex ways. Inflammation is generally considered to be a good thing.  Without it, pathogens like bacteria and viruses could easily take over our bodies and kill us. 
However, there is another type of inflammation that may be harmful and often referred to as chronic inflammation, low-grade inflammation or systemic inflammation.  We now believe that chronic inflammation is the leading driver of some of the most serious diseases including obesity, heart disease, type 2 diabetes, Alzheimer’s disease, depression, chronic pain, and numerous others.  Unfortunately, it hasn’t been “proven” what causes inflammation in the first place.  As earlier stated, due to the complexity of the causes it may in fact be hard if even possible to prove within the realm of current research standards.  We do know however, that there is high correlation of increased gut permeability often termed “leaky gut” in most individuals with serious chronic inflammatory diseases.  Please note – research has shown there are benefits at times to leaky gut and the body will create this picture during high stress times when the immune system is needing more nutrients and water absorption – for ex. During acute illness and fight or flight instances.   This is usually the rebuttal of most GI specialists – that increased gut permeability is necessary at times as well as the “there is not enough research to prove that it is a legitimate issue” – The problem arises when the leaky gut isn’t transient and continues indefinitely.  Therefore, investigating the gut and the function of the GI tract is usually very high on the “to do” list for those suffering from debilitating and chronic disorders.  When someone is severely ill with very low quality of life waiting for complete proof is not a feasible option.  We have many functional types of tests to help us understand more closely what may be happening within the GI tract and the more information and the better understanding we have of a patient’s physiology the better we can teach and guide them to a state of less disease and better health.
There are many functional gastrointestinal tests that we often recommend here at VIS CLINIC.  These include the following:  Complete digestive analysis with parasitology, intestinal permeability assessment, Small intestinal bacterial overgrowth, lactose intolerance breath test, H pylori stool antigen as well food allergy testing.  Anyone with chronic illness could benefit from these tests but especially if you suffer from the following:  Heartburn, gas/bloating, problems swallowing, nausea/vomiting, excessive belching, constipation, IBS, diarrhea, allergies/asthma, joint pains, history of opiate use, prostatitis, and menstrual disorders.

We will be having a lecture January 16 if you would like to learn more on available testing options and what you may learn!

We are excited that all of our Vis Clinic Lectures now take place at 86 Cold Press

in downtown Wichita at 600 E Douglas Avenue
(Douglas & St Francis) 
Wichita, KS

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Nurse's TIP 
Hydrate before your IV and lab – it is okay (and encouraged)
to drink lots of water before we access your veins!

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New Cleveland Heart Lab Testing at Vis Clinic
Vis Clinic is now using both Cleveland Heart Lab and Boston Heart Lab for screening of specific biomarkers that to help evaluate a patient’s risk for cardio-metabolic events.  Ask a Vis Clinic Nurse which test may be right for you. The new tests are exciting because they help the Vis Clinic Doctors offer more individualized biochemical planning for the person sitting in front of them.
Vis Clinic has long reported that approximately 50% of heart attacks and strokes occur in patients with ‘normal’ cholesterol levels. An advanced lipid assessment or measuring the number of apolipoproteins or lipoprotein particles present, has been shown to better predict cardiovascular disease (CVD) risk than traditional lipid tests. Atherogenic particles can infiltrate the blood vessel wall contributing to atherosclerotic plaque formation (hardening of the arteries), and CVD events. Although it is essential to assess cholesterol levels, adverse events (such as a heart attack, stroke, or death) have been associated with inflammation, specifically vulnerable plaque related to increased white blood cell activation. The prominent clinical trials that have looked deeply into heart disease, JUPITER (2009) and CANTOS (2017), characterize inflammation as a critical component of atherosclerotic disease and cardiovascular risk, independent of lipids.
In 1976, world-renowned vascular biologist, Dr. Russell Ross, proposed the “Response to Injury Hypothesis”, providing insight into the initiation and subsequent progression of cardiovascular disease. Risk factors such as smoking, hypertension, and diabetes can damage the vessel wall, making it more susceptible to penetration and accumulation of bad oxidized cholesterol. The body responds to the injury with an inflammatory response designed to remove cholesterol from the artery wall. This process becomes dysregulated and ultimately potentiates the progression of cholesterol deposition and vulnerable plaque formation, placing an individual at increased risk of plaque rupture and subsequent heart attack or stroke.
Cleveland Heart Lab offers additional inflammatory biomarker testing to help Vis Clinic Doctors evaluate cardiovascular risk in patients. This group of tests covers a patient’s biomarker profile, which may result from lifestyle concerns to the development of cardiovascular disease and formation of vulnerable plaque and increased risk for an adverse event.
No one marker can clearly point to disease and that is in fact an old paradigm of clinical “wishful” thinking. Research supports the concept that combining multiple markers increases our ability to risk-stratify for cardiovascular disease.

Some new additions to Vis Clinic for evaluating inflammation:
F2-Isoprostanes (F2-IsoPs)
F2-IsoPs are prostaglandin-like compounds formed from the free radical-mediated oxidation of arachidonic acid (omega 6 fat). They are the ‘gold standard’ for measuring oxidative stress in the body. Additionally, F2-IsoPs may also act as potent vasoconstrictors (blood vessel contracts) via thromboxane formation in the endothelium (blood vessel cell lining), which can promote platelet activation resulting in thrombus (clot) formation.
Clinical Significance of F2-Isoprostanes (F2-IsoPs)
Elevated levels of urinary F2-IsoPs are seen in conditions associated with increased risk for atherosclerosis and certain forms of cancer. F2-IsoPs are elevated in smokers and with increased intake of red meat and are decreased with exercise. Lower steady-state levels are associated with cardiovascular fitness and reduced risk of heart disease.
Oxidized LDL (OxLDL)
OxLDL measures protein damage due to the oxidative modification of LDL cholesterol (considered the bad cholesterol). The oxidation of LDL cholesterol is one of the first steps in the development of atherosclerosis. Briefly, LDL-C enters the artery wall where it becomes oxidized. OxLDL leads to vascular inflammation and the initiation of atherosclerosis
Clinical Significance of Oxidized LDL (OxLDL)
Individuals with high levels of OxLDL are 3.5X times more likely to develop metabolic syndrome in the next 5 years.
Increased OxLDL levels are associated with the presence of coronary artery disease.
In healthy middle-aged men, high OxLDL levels are associated with a 4X greater risk of developing coronary heart disease.
Levels of OxLDL increase in a step-wise fashion as the severity of CAD increases.
OxLDL levels may be elevated in patients with kidney disease and polycystic ovary syndrome (PCOS).
OxLDL levels can rise in patients with known autoimmune disorders (non-cardiovasular).

One of the earliest manifestations of endothelial (blood vessel cell) dysfunction is nitric oxide (NO) deficiency, which promotes atherosclerosis. ADMA (asymmetric dimethylarginine) and SDMA (symmetric dimethylarginine), its structural isomer, are metabolites of L-arginine, an amino acid that is catalyzed to L-citrulline and NO by nitric oxide synthase (NOS). ADMA and SDMA reduce NO production and promote endothelial dysfunction.

Clinical Significance of ADMA/SDMA
 Cardiovascular Significance: Elevated ADMA levels are associated with the presence of hypertension, insulin resistance, and high lipids. Elevated ADMA levels are associated with subclinical atherosclerosis: Elevated ADMA concentrations correlate with internal carotid artery thickness, nitric oxide deficiency and plaque formation. Elevated ADMA in young adults has been associated with increased coronary artery calcification (CAC) score. Individuals with established coronary artery disease and elevated ADMA levels have more than twice the risk for adverse events (MI, stroke) than those with normal ADMA levels.
Renal Significance: Elevated SDMA levels positively correlate with reduced kidney function.
Treatment Considerations with the ADMA/SDMA test
The ADMA/SDMA test is exciting because it helps us focus nutrient therapy as warranted to promote nitric oxide production. If ADMA or SDMA is elevated, we would consider L-Arginine or L-Citrulline supplementation to improve vasodilation and vascular tone. L-Arginine and L-Citrulline enhance the production of nitric oxide which has anti-inflammatory, antithrombotic, antihypertensive, and antioxidant effects.
A new addition to Vis Clinic for Metabolic Testing: The GUT and CARDIOVASCULAR CONNECTION

Trimethylamine N-oxide (TMAO)
Gut microbes live symbiotically within the human digestive tract and play important roles in host defense, immunity, and nutrient processing and absorption. This diverse community is unique to each person and influenced by both acute and chronic dietary exposures to various food sources. Nutrients such as lecithin, and L-carnitine are abundant in animal-derived products such as red meat, egg yolk and dairy products. When consumed, these nutrients are processed by gut bacteria resulting in the release of various metabolites including TMA (trimethylamine) into the blood. TMA is then transported to the liver where it is converted into TMAO (trimethylamine N-oxide). TMAO has been shown to regulate various physiological processes which are involved in the development of atherosclerosis as well as reverse cholesterol synthesis and platelet function
Clinical Significance of Trimethylamine N-oxide (TMAO)
There is a dose-response relationship between TMAO and atherosclerotic burden and major adverse cardiovascular events incidence (MACE: MI, stroke or death). In stable individuals undergoing elective cardiac evaluation, elevated TMAO levels are associated with increased risk of cardiovascular disease and MACE. Increased plasma L-Carnitine (a dietary precursor to TMAO) is associated with cardiovascular risk only when TMAO is simultaneously elevated via the metabolism by specific gut microbes.
Independent Risk Factor
In subsets of the population considered ‘low risk’ (<65 years old, <100mg/dL LDL-C, normal blood pressure, non-smokers, low levels of MPO), elevated TMAO remained a significant predictor of MACE risk.
Elevated TMAO increases 7-year mortality risk in patients admitted to the ER who presented with acute coronary syndrome as well as 5-year mortality risk in patients with CAD receiving optimal therapy and PAD (peripheral arterial disease) patients
 The TMAO tests is exciting because it offers a targeted direction for diet recommendations as well as the need to treat the GUT to help the CARDIOVASCULAR system.
Treatment Considerations for elevated TMAO include
Consider implementing a Mediterranean or plant-based diet.
A more diverse diet rich in vegetables can improve the health of the gut microbiota.
Consider limiting the intake of foods rich in TMA precursors such as red meat, eggs, and/or dairy products. NOTE: Certain types of seafood contain high levels of TMAO particularly saltwater fish, sharks, rays, mollusks, and crustaceans.
Arctic deep-sea fishes are known to be rich in TMAO while surface fishes (trout) contain much less TMAO. These food sources may falsely elevate TMAO levels.
Consider probiotic/prebiotic supplementation to promote gut bacterial biodiversity to lower TMAO.
Consider discontinuing the use of lecithin or L-carnitine containing supplements in individuals with elevated TMAO levels. This test helps us discern whether L-carnitine may be beneficial or harmful for patients.
There are many more new tests being offered but this article is getting carried away already. To find out more information about some of the advanced cardiometabolic testing being offered at Vis Clinic come to the lecture on February 20, 2019.
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Vis Clinic Case Study 

At the beginning of October 2018 a 26 Y/O male presented to Vis Clinic with reported hypertension discovered at a health fair.
Upon assessment, his blood pressure was found to be 176/110 mmHg. The patient had no known personal history of hypertension.
Dr. Chad Krier ordered labs and also placed an order for the patient to have IM magnesium injections twice per week to lower his blood pressure while waiting on lab results. Blood pressure was assessed before and after each injection. A steady decrease in the patient’s blood pressure was observed over the next several weeks, with the lowest being 132/ 78 mmHg.

When the patient’s lab results were returned he was found to have high lead levels – they had increased to 27 times the unprovoked levels after a chelating agent was used with a simple 6-hour urine collection. As treatment, the patient has undergone a 12 week series of three-hour chelations. His blood pressure at last measurement was 126/78 mmHg in comparison to 176/110 mmHg at the beginning of treatment.
The patient continues to see Dr. Krier for follow-ups.

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Allergies and Asthma
“Allergies” is the immune system overreacting to benign substances.  Individuals who suffer from allergies do so as a result of a genetic susceptibility combined with nutritional and environmental influences. While heredity has been emphasized in the past, it is clear that genetics alone cannot account for the worldwide increase in asthma and allergy prevalence. The International Study of Asthma and Allergies in Childhood and the European Community Respiratory Health Surveys have shown some striking patterns. Asthma is more common in Western countries than developing countries, more prevalent in English speaking countries, and are increases in incidence in developing countries as they become more “Westernized”.  This is definitely telling us that the environment and lifestyle in westernized countries are a factor in the production of allergies in the population.
Our bodies are exposed to a virtual barrage of chemicals each year in the form of air pollution, pesticides, toxic household cleaners, and industrial contaminants. It is not surprising that at times our immune system is overwhelmed and confused by this toxic load. Epidemiological studies have shown that all types of allergic diseases are more common in polluted areas than in unpolluted ones
While many of these exposures are beyond our control, a number of them are within our control. By working to decrease pollution inside and outside of the home as well as pollution within our foods, we will be treating one of the major root causes of disease and practicing truly preventative health care.
From a Naturopathic Viewpoint, removing and/or decreasing exposure to the cause is the first step to treating allergies and asthma.  The next step is identifying any and all food sensitivities.  Most people have some food sensitivities and when we decrease the immune reactivity in one area of the body it can decrease in other areas as well.  In other words, any decrease in the overall allergenic load will decrease full body symptom expression.  And since we can control what we put in our mouth, this is the best first place to start after removing evident toxic chemicals from our foods.
The next step is to address general nutritional considerations that will help allergic symptoms.  Our goal through nutrition is to decrease histamine, decrease inflammation, and increase anti-allergic substances in our diet. Foods high in histamine which should be avoided are cheese, some wines, and certain kinds of fish such as tuna and mackerel. Foods rich in tryptophan should also be reduced because tryptophan encourages histamine production. These include cottage cheese, liver, peanuts, turkey, lamb, tuna, beef, salmon and cashews. Animal fats (especially grain fed beef, pork and lamb) generally increase inflammatory prostaglandins and should therefore be kept to a minimum.  Wild (as long as they are not eating crops) and grass fed animals would be the best choice. Foods to include are anti-oxidant rich foods and essential fatty acids. Anti-oxidants are high in green, red and yellow vegetables, sunflower seeds, wheat germ oil, and brazil nuts. Essential fatty acids are present in flaxseed oil, borage oil, evening primrose oil, grass fed animals, and cold water fish. Onion and garlic are particularly antiallergic because they inhibit inflammatory enzymes.
After addressing the nutritional considerations, we want to address the three main organs that play a role in allergies: The Bowels, the liver and the adrenal glands.  We want to make sure the allergic patient has a good population of the good gut bacteria and is having regular bowel movements at least 1-2 times per day.  History of constipation is a Red Flag for cause of allergies because of the inefficient removal of toxic waste. 
The next organ is the liver which it responsible for detoxification.  It removes hormones, drugs and chemicals, filters all blood coming from the digestive tract, and makes toxins water soluble for excretion. The liver is commonly overwhelmed by environmental pollution and can be supported through herbs and supplements to make it more efficient. Common supplements include Milk Thistle, a liver herb that promotes liver cell regeneration, and N-Acetyl Cysteine (NAC), an amino acid and precursor to glutathione that supports the central antioxidant and detoxification pathway of the liver. Oral NAC is also a great “Mucolytic” or mucous thinning agent that is great for upper respiratory mucous as well as excessive GI mucous.
The third organ is the adrenal glands.  The adrenal glands release the stress hormone cortisol and are therefore worn out often by our high stress lives that we all lead. Cortisol also plays an important role in regulating the immune system. In fact, a conventional pharmaceutical approach to allergies and asthma is prednisone, an artificial high dose form of cortisol. So it makes complete sense to say that stress and weakened adrenals can make us susceptible to “allergies” and allergic symptoms.
The last step in a Naturopathic Approach is symptom management and suppression.  Suppression of symptoms in some cases is not always a bad approach if we are working on the underlying causes at the same time because it can provide relief.  And relief will mean better sleep and less stress which will in turn help in the process of treating the causes.  Supplements that decrease histamine release by stabilizing the mast cells are Vitamin C, vitamin E and lots of bioflavonoids especially quercitin which has an affinity for the lungs and upper respiratory tract. These are the nutrients that do the best of both worlds – fight the symptoms at the same time as the underlying cause.
During the lecture on March 20th, we will discuss Food and environmental allergy testing and the use of desensitization drops as a treatment consideration.  Conventional desensitization involves vaccinations that are physically uncomfortable and increases exposure to more additives and preservatives from the vaccines themselves.  The oral desensitization drops is a low invasive option that can mitigate hypersensitivity reactions and slowly build tolerance to specific antigens, consequently providing relief of symptoms and overall less bodily discomfort.
Please join us on March 20th to learn more!

Allergy and Food Sensitivity Testing Offered at Vis Clinic
There are 3 categories of diet-induced inflammatory reactions: Food Allergy, Food-Induced Autoimmune Disease, and Food Sensitivities. Of the 3, food sensitivities are the most prevalent.
Food and food-chemical sensitivities are highly complex non-allergic (non-IgE), non-celiac inflammatory reactions. They follow multiple inflammatory pathways and may be governed by either innate or adaptive immune mechanisms. They’re one of the most important sources of inflammation and symptoms across a wide range of chronic inflammatory conditions. They are also one of the most clinically challenging.
Due to their inherent clinical and immunologic complexities, as well as a lack of general knowledge within conventional medicine of their role as a source of inflammation in IBS, migraine, fibromyalgia, arthritis, GERD, obesity, metabolic syndrome, ADD/ADHD, autism, etc., food and food-chemical sensitivities remain one of the most under addressed areas of conventional medicine.
Food and food-chemical sensitivities have clinical characteristics that make it very challenging to identify trigger foods. For example, symptom manifestation may be delayed by many hours after ingestion; reactions may be dose dependent; because of a breakdown of oral tolerance mechanisms, there are often many reactive foods and food-chemicals; even so-called anti-inflammatory foods, such as salmon, parsley, turmeric, ginger, blueberry, and any “healthy” food can be reactive.
Recent research into adverse reactions to gluten has uncovered a new form of diet-induced inflammation termed “non-celiac gluten sensitivity” (or GS). Gluten sensitivity is 6-8 times more prevalent than celiac disease, can provoke a wide range of clinical symptoms, and has been proven to activate the inate immune system, a branch of the immune system that has been completely neglected for years by researchers as a source of diet-induced inflammation and symptoms. But gluten is just one potential piece of the puzzle. As stated previously, any food can trigger an inflammatory response, even so-called anti-inflammatory foods. The key is to know which specific foods and food-chemicals are triggering reactions in each specific patient. That’s the beginning of the best way to design an eating plan that will produce the maximum clinical benefit.
The single common feature of all diet-induced inflammatory reactions is that they ultimately cause mediator release (cytokines, leukotrienes, prostaglandins, etc.) from various white blood cells (neutrophils, monocytes, eosinophils, lymphocytes). This is true whether reactions are immediate or delayed, whether dose dependent or not, whether governed by the innate or adaptive immune systems, whether cell-mediated or humorally-mediated, and whether inflammation remains at a sub-clinical level or becomes clinically symptom-provoking. All food-induced inflammatory reactions involve mediator release, which is the single most important event leading to all the negative effects that patients suffer, including symptom generation.
Food Sensitivity
The Patented Mediator Release Test (MRT®) (Whole Blood Test)
Despite all the clinical and immunologic complexities associated with food sensitivities, the single common component of all diet-induced inflammatory reactions is proinflammatory and proalgesic mediator release from white cells. It’s the release of cytokines, histamine, leukotrienes, prostaglandins, etc., from neutrophils, monocytes, eosinophils and lymphocytes that lead to all the negative clinical effects a food sensitivity sufferer endures. This is true under all the numerous immunologic circumstances and clinical circumstances associated with food sensitivities. Because of the vast array of potential mediators and reacting cells, measuring volumetric changes in all circulating white cells after antigen challenge is the most logical, direct, comprehensive and functional measure of food sensitivity reactions. 
MRT® is a functional measurement of diet-induced sensitivity pathways. MRT® simplifies a highly complex reaction and translates that into the most useable clinical information you can get – quantifying the inflammatory response to foods and food-chemicals.
Not only does MRT® give insight into inflammation provoking foods and food-chemicals, but more importantly MRT® identifies your BEST foods – the foods that form the basis of the individualized Eating Plan.
IgG Food Antibody Blood Test (Serum Test)
IgG Food Antibody Assessment is a food sensitivity test which helps identify those with IgG-mediated food sensitivities. This immunological food sensitivity test measures IgG antibody levels to 87 foods Additional sensitivity tests are also available for vegetables, and spices. This antibody food sensitivity test is ideal for patients who may suffer from delayed reactions/sensitivities to specific foods. It may also provide insight on intolerances, or non-immune responses, to certain foods. Additionally, the IgG Food Antibody Assessment includes information on implementing an Elimination Diet based on the patient test results.
Why Use the IgG Food Sensitivity Test?
The incidence of food sensitivities has increased dramatically over the years. It is estimated that up to 20% of the population have adverse reactions to foods, NSAID enteropathy, and post-infectious Irritable Bowel Syndrome (IBS).
Increased total antigenic load related to food and environmental sensitivities has been associated with a wide range of medical conditions affecting virtually every part of the body. Mood and behavior, including hyperactivity disorders in children are profoundly influenced by food allergies.
IgG-Mediated Symptoms May Include:
  • Asthma
  • Arthritis
  • Migraines
  • Ear Infections
  • Eczema
  • Sinusitis
  • Urticaria
  • Colitis
Classic skin testing for allergies such as skin-scratch testing only measures IgE-mediated reactions. Assessment of relative IgG antibody levels to a multitude of foods using sensitive Enzyme-Linked-Immnosorbent Assay (ELISA) technology identifies those foods against which the patient is producing antibodies. Measuring IgG antibody levels provides an invaluable starting point for dietary intervention.
Allergix® IgG4 Food Antibodies Test - Bloodspot 30
The Allergix IgG4 Food Antibodies is a food sensitivity test which uses a simple blood spot to measure the total IgG levels reacting to common food antigens. IgG4 antibody is related to delayed or non–atopic food reactions that exacerbate or contribute to many different health problems. This antibody food sensitivity test is ideal for patients who may suffer from delayed reactions/sensitivities to specific foods.
Why choose the Bloodspot IgG Food Antibodies Profile for food sensitivity testing?
From a simple finger stick, the Bloodspot IgG4 Food Antibodies Profile offers a non–invasive alternative to a blood draw in determining IgG food sensitivity reactions. Responses to 30 different foods are tested, and responses are categorized by severity from borderline to mild, moderate, or severe on the report.
IgG4 antibodies are associated with non–atopic or "delayed" food reactions that can worsen or contribute to many health conditions. Food intolerances (also known as food sensitivities) can occur at any age, triggering a wide range of symptoms. This test is ideal for children where it may be difficult to draw enough blood for a complete serum profile.
Food and Inhalant Allergy
IgE Food Antibodies Blood Allergy Test (Serum Test)
IgE Food Antibodies is a food allergy test which analyzes serum levels of IgE antibodies for 19 combined foods, as well as Total IgE. This is an ideal food allergy test for patients who may suffer an immediate reaction (allergy) or non-immune response to specific foods, such as peanuts or shellfish.
The IgE allergic response is the most well-known food allergy reaction. IgE food allergy reactions usually occur immediately after the ingestion of offending foods, such as peanuts or shellfish. The IgE Food Antibody Profile measures levels of antigen-specific IgE to common foods.
IgE-Mediated Food Allergies:
  • Immediate symptom onset (within minutes)
  • Circulating half-life of 1-2 days
  • Permanent allergies
  • Stimulates histamine release
IgE Inhalants - Allergy Test (Serum Test)
The IgE inhalants is an allergy test which evaluates serum IgE antibody levels region-specific common pollens and environmental inhalants. This is an ideal allergy test for patients with suspected environmental and/or seasonal allergies. Specifically, this allergy test evaluates 14 common environmental inhalants specific to 18 North American geographic regions and Total IgE.
IgE Mold - Allergy Test (Serum Test)
The IgE Mold Test is an allergy test which evaluates serum IgE antibody levels to 15 molds. This is an ideal allergy test for patients with suspected environmental mold allergies. Specifically, this allergy test evaluates antibody levels to 15 common molds and Total IgE.
Food-Induced Autoimmune Disease
Celiac & Gluten Sensitivity Blood Test
The Celiac & Gluten Sensitivity test tests a patient's blood for total IgA as well as IgA specific antibodies for possible celiac disease or gluten sensitivity. Celiac disease, also known as celiac sprue or gluten sensitivity enteropathy, is a chronic autoimmune disease which has a genetic component and may affect several family members. Celiac is a lifelong condition with no cure however, it is manageable once diagnosed.
The test includes
Anti-Deamidated Gliadin IgA (DGP IgA)
Anti-Gliadin IgA
Anti-Gliadin IgG
Anti-Tissue Transglutaminase IgA
EMA IgA (reflex Only)
Total IgA
What is Celiac Disease?
Celiac disease is a digestive condition triggered by consumption of the protein gluten, which is found in bread, pasta, cookies, pizza crust, and many other foods containing wheat, barley, or rye. When a person with Celiac Disease eats food containing gluten, an immune reaction occurs in the small intestine, resulting in damage to the surface of the small intestine and an inability to absorb certain nutrients from food.
Conditions, diseases, and symptoms related to Celiac Disease:
  • Abdominal cramps, gas, and bloating
  • Anemia
  • Crohn's Disease
  • Diarrhea
  • Foul-smelling or grayish stools that may be fatty or oily
  • Gastric ulcers
  • General weakness
  • Intermittent diarrhea
  • Irritable Bowel Syndrome (IBS)
  • Osteoporosis
  • Parasitic infections
  • Skin disorders
  • Stunted growth (in children)
  • Weight loss
  • Lupus erythematosus
  • Type 1 diabetes
  • Rheumatoid arthritis
  • Autoimmune thyroid disease
  • Microscopic colitis
Gluten Sensitivity
Remember as state above that Gluten sensitivity is 6-8 times more prevalent than celiac disease, can provoke a wide range of clinical symptoms, and has been proven to activate the innate immune system, as a source of diet-induced inflammation and symptoms. Gluten sensitivity is not an auto-immune condition.
To learn more about Allergy and Food Sensitivity Testing Offered at
Vis Clinic come to
Dr. Jennifer Mead’s lecture on March 20, 2019.

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from our Supplement Store

Happy New Year!
It's this time of the year, when we all like to focus on health, cleansing,
weight loss and energy to start the New Year out right!
At the Vis Clinic Supplement Store we have some products that can
focus on just that . . . 
PGX Daily

PGX Daily supports healthy blood sugar levels within normal ranges, reduces appetite, and helps inhibit weight gain. PGX (PolyGlycopleX) helps normalize and stabilize blood sugar, lowers insulin secretion, and improves insulin sensitivity. PGX can lower after-meal blood sugar, levels, reduce the glycemic index of meals, help control appetite for healthy weight loss, help burn body fat, balance cholesterol and reduce triglycerides, and improve regularity.


Vis Energy Drink

Who wouldn't want more energy! 
Vis Energy Drink transforms water into a great-tasting, revitalizing energy drink. Each stick provides a combination of B vitamins, electrolytes, trace minerals, amino acids, herbs, and antioxidants to fuel your body’s energy production. Building on these important nutrients, Vis Energy Drink also features Purenergy™, a technology-driven, patent-protected ingredient that combines caffeine and pTeroPure® pterostilbene. Initial reports suggest that Purenergy’s caffeine may be absorbed more slowly and stay in your system longer than regular caffeine, which may help your energy last longer. With just 5 g of carbohydrate per serving and zero sugars,
Vis Energy Drink simply gives your body what it needs to produce energy

Vis Protein Products!

Vis Cleanse Plus is an optimal cleansing formula that supports the body natural detoxification mechanisms and supports healthy hormone metabolism. Vis Cleanse Plus is a functional food containing the macro and micronutrients that support...
Vis Cleanse/GI Support is a functional food with optimal gastrointestinal, hepatic, and inflammatory support, suitable for vegans. Vis Cleanse/GI Support contains a variety of macro- and micro-nutrients, herbs and other nutraceuticals to support and optimize detoxification in those who have signs or conditions associated with toxicity; it also supports the gastrointestinal mucosa and healthy gastrointestinal mucosa, healthy essential fatty acids, and prostaglandin production. Vis Cleanse/GI Support also features a proprietary VegaPro™ pea/rice protein blend for better-tasting, higher-quality, “optimal cleansing” nutrition, and Aminogen® to facilitate protein absorption.
Vis Glycemic Control provides support for healthy glucose and insulin metabolism with highly bioavailable ingredients. Glycemic Control helps reduce glycemic impact of meals, supports healthy body composition and healthy blood lipid metabolism. Glycemic Control also provides antioxidant support and supports maintenance of healthy peripheral nerves.
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