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This is a special report about Gossypin, a compound with wide therapeutic potential.
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Gossypin Special Report

This is a special report from INDOFINE Chemical Company about Gossypin, a compound with wide therapeutic potential. We are the bulk supplier for Gossypin, as well as many other natural products, including the well-documented Piperlongumine and Plumbagin compounds. 
Gossypin is a naturally occurring bioactive flavonoid glucoside that belongs to Malvaceae family. This natural compound is typically found in fruits and vegetables. It is commonly found in the flowers of Gossypium indicum, Hibiscus vitifolius and Hibiscus esculentus. Among them, Hibiscus vitifolius is a rich source of Gossypin.
Hibiscus Blossom
Hibiscus Blossom, a source of Gossypin.
CC Image courtesy of D.L. on Flickr
Gossypin is a water soluble compound. This is attributed to the presence of glucose moiety at the 8th position of the hexahydroxyflavone ring. The most-studied derivatives of Gossypin exhibit anti-oxidant, neuroprotective, anti-inflammatory, anti-diabetic and anti-cancer properties.

Gossypin as an Anti-cancer Agent

Studies have shown great potential of Gossypin as an anticancer agent. It has shown to be effective in preventing different types of cancers as demonstrated by various lab studies.
 
In 2010, Gossypin was isolated, and a series of Gossypin derivatives were synthesized and analysed for increased biological activities (2). These derivatives were then tested for their anti-cancer potential on HeLa and HT29 cell line. These derivatives of Gossypin showed better anticancer activity as compared to Gossypin.

In one of the other studies carried out (7), the potential anti-cancer effects of Gossypin on malignant gliomas (primary brain tumors) was investigated. The study showed that the treatment of human glioma cells with Gossypin inhibited cell proliferation in a dose-dependent and time-dependent manner. Furthermore, the treatment was observed to be minimally toxic to normal human astrocytic cells.

Other studies demonstrating the mechanism of action of Gossypin suggested that the anti-inflammatory, anti-carcinogenic, and anti-angiogenic properties of Gossypin result from inhibition of NF-B and NF-B-regulated gene expression. Nuclear factor-B (NF-B) is an inducible transcription factor for genes involved in cell survival, adhesion, inflammation, differentiation, and growth. It regulates the genes that are critical in the early and late stages of aggressive cancers (3).

A 2013 study by Hareesh B Nair et al demonstrated the use of Gossypin for treatment of melanoma skin cancers. Gossypin stopped cancer cell growth in various human melanoma cells. Treatment with Gossypin also resulted in reduced tumor volume through induction of apoptosis, and it increased survival rate in mice. It works by shunting kinase activities of BRAFV600E and CDK4 in vitro, possibly through direct binding with them (3).


Gossypin as an Anti-oxidant and Neuroprotectant

Gossypin known to possess antioxidant properties. The mechanism of action involves suppression of free radicals that cause oxidative stress. Gossypin inhibited lipid peroxidation initiated by Fe2+ and ascorbic acid in rat brain homogenates in a recent study (1). It also showed significant radical scavenging activity generated from 1,1-diphenyl-2-picrylhydrazyl. The results of their studies indicate that Gossypin exerts neuroprotective effects in the cultured cortical cells by inhibiting oxidative stress. The antioxidant properties of Gossypin may also be responsible for its neuroprotective actions.

Gossypin as an Anti-diabetic Agent

Gossypin has also been evaluated for its anti-diabetic potential (8). In order to determine its effect, a predetermined dose of Gossypin was given orally to streptozotocin (STZ)-induced experimental diabetic rats for 30 days. Administration of Gossypin to diabetic rats resulted in improved glucose tolerance after 28 days. Increased blood glucose and HbA1c levels and reduced plasma insulin and hemoglobin levels in diabetic rats were significantly reversed to near normal levels after oral administration of Gossypin. Furthermore, the glycogen content of the liver and muscles was significantly improved after Gossypin treatment of diabetic rats.


References:

  1. Injae Yoon et al. Archives of Pharmacal Research. April 2004; 27(4): 454-459
  2. Kotra V, Ganapaty S & Adapa SR.Indian Journal of Chemistry. 2010; 49B:1542-1546.
  3. Kunnumakkara ABNair ASAhn KSPandey MKYi ZLiu MAggarwal BB. Blood. 2007 Jun 15; 109(12):5112-21
  4. Mada SRMetukuri MRBurugula LReddanna PKrishna DR. J Exp Clin Cancer Res. 2003 Dec; 22(4):581-9
  5. NS ParmarMN Ghosh. Indian journal of Pharmacology.1978 ;10(4): 277-293
  6. Ramaswamy S, Viswanathan S. Indian J Exp Biol. 1997 Apr; 35(4):413-4.
  7. Shi L et al. Cell Mol Neurobiol. 2012 Mar; 32(2):289-96.
  8. Thamizhiniyan Venkatesan, Subramanian Sorimuthu Pillai. J Diabetes. 2012 Mar; 4 (1):41-6
Gossypin Structure

Gossypin

Synonym: 3,3',4',5,7,8-Hexahydroxyflavone-8-glucoside
Catalog Number: G-002
CAS: 652-78-8
MDL: MFCD00017429
Formula: C21H20O13
Purity: 98+%
MW: 480.38
MP: 210-217°C (dec)
Appearance: Yellow powder
Solubility: DMSO
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Our capabilities and experience make us the perfect solution for all of your manufacturing needs. For more information, or to inquire about a product, please visit us at www.indofinechemical.com, call at 1-908-359-6778, or reply to this newsletter today!
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