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The Furocoumarins

The furocoumarins, or furanocoumarins, are a class of organic chemical compounds produced by a variety of plants.The chemical structure of furocoumarins consists of a furan ring annulated with coumarin. The furan may be fused in different ways producing several isomers. The compounds that form the core structure of the two most common isomers are psoralen and angelicin.

Many furocoumarins are toxic and are produced by plants as a defense mechanism against various types of predators ranging from insects to mammals. 

Below you will find summaries of the notable attributes of various furocoumarins and related compounds. To the best of our knowledge, the information contained herein is accurate and reliable as of the date of publication; however, INDOFINE Chemical Company makes no guarantee of validity or accuracy.

All of these compounds are manufactured in-house at INDOFINE Chemical Company, and may be ordered directly from our website at indofinechemical.com.

Psoralen

Catalog #: 020504
CAS #: 66-97-7

Psoralen is the parent compound in the furocoumarin family. It is structurally related to coumarin by the addition of a fused furan ring, and may be considered as a derivative of umbelliferone.

It is widely used in PUVA (psoralen + UVA) treatment for psoriasis, eczema, vitiligo, and some cutaneous lymphomas.

Xanthotoxin
(Methoxsalen, 8-Methoxypsoralen)

Catalog #: 020530
CAS #: 298-81-7

Used in conjunction with PUVA treatment for skin ailments, Xanthotoxin is a drug that modifies the way skin cells receive UVA radiation.

Bergamottin (5-Geranyloxypsoralen)

Catalog #: 19-335
CAS #: 7380-40-7

Bergamottin is a natural furanocoumarin found principally in grapefruit juice. It is believed to be among the compounds responsible for the grapefruit juice effect, in which the consumption of the juice affects the metabolism of a variety of pharmaceutical drugs.

Bergapten (5-Methoxypsoralen)

Catalog #: 020503
CAS #: 484-20-8

Bergapten is the compound in bergamot oil that causes phototoxicity.

Bergaptol (5-Hydroxypsoralen)

Catalog #: 19-230 
CAS #: 486-60-2

A component of bergamot oil.

Isopimpinellin (5,8-Dimethoxypsoralen)

Catalog #: 19-661 
CAS #: 482-27-9

There have been several studies investigating potential anticarcinogenic properties of Isopimpinellin and other so-called naturally occurring furocoumarins as anticarcinogens.

Umbelliferone (7-Hydroxycoumarin)

Catalog #: H-017
CAS #: 93-35-6

Umbelliferone is a widespread natural product of the coumarin family, and a parent compound to the furocoumarins. The compound absorbs ultraviolet light strongly at several wavelengths, and despite several indications that it is photomutagenic, it is used in sunscreens. Umbelliferone has also been reported to have antioxidant properties.
INDOFINE Chemical Company is committed to providing high quality rare organic molecules, biochemicals and natural products for research purposes. We also offer custom synthesis, contract research, process development and toll manufacturing for the pharmaceutical, agricultural and life science industries.

If you are interested in these or any of our other products, please give us a call at 1-908-359-6778 or reply to this email today. For more information about our company or capabilities, please visit our website at indofinechemical.com.
Disclaimer: All information is sourced from Wikipedia and its references. The information, statements and recommendations in this publication are to the best of our knowledge, information and belief accurate at the date of publication. Nothing herein is to be considered as a warranty, expressed or otherwise. In all cases, it is the responsibility of readers and users to determine the applicability of such information for their own particular purpose. Nothing in this publication is to be considered as recommending the infringement of any patent or other intellectual property right. Nothing in this publication is to be viewed as a license under any intellectual property right. None of INDOFINE Chemical Company's products are sold for human consumption.
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