Upgrade your cell-based assays to 3D  
InSphero Newsletter Sept 2014
Dear <<First Name>>,

In this month's newsletter we take you back to school with the latest news, publications, trends, and meetings to keep you updated on the state of 3D microtissue models for in vitro toxicity and efficacy testing.  

Liver Microtissues Help Resolve In Vitro SR-BI Receptor Localization 
InSphero Posters from WC9 and EUROTOX Now Online

Disease Modeling
State-of-the-Art in 3D Microtissues: An Update

Imaging & Automation
New Video:  Meet the Cell3iMager

Company & Distributor News
Join Our San Francisco and Boston User Group Meetings
Meet InSphero at the 3rd Annual TEDD Meeting
Lit Picks: Simon Says "Don't miss these papers!"

"My name is Jennifer Staudigl.  I am from Berlin and recently joined InSphero for my masters internship in Biotechnology.  I am extremely thankful for the opportunity to gain an insight of InSphero`s industry and their energetic, welcoming work environment.  I look forward to developing both expertise and novel 3D cell-culture models with the InSphero team!"


Join our San Francisco & Boston User Group Meetings

Dates have been set for our 3D cell culture workshops in San Francisco
(Oct 24) and Boston (Nov 20).  Keep updated on the latest advances in 3D cell culture technology and applications by attending one or both of the focused half-day sessions for Toxicology (AM) or Oncology (PM).  Preliminary agendas include guest speakers from Genentech, Promega, and Seahorse Bioscience.  Space is limited, so reserve your seat today!

InSphero Posters from WC9 and EUROTOX Now Online

As summer was winding down, our team was busy with a combined 12 presentations and posters at these two key European conferences.  Visit our poster page to download digital versions of our meeting presentations.  

Meet InSphero at 3rd Annual Tissue Engineering Meeting

Join the upcoming TEDD annual meeting in Waedenswil, Switzerland to hear recent advances in 3D cell culture, network with industry and academic experts and peers, and see InSphero's latest microtissue models. Find out more about this October 9th meeting!

Liver Microtissues Help Resolve In Vitro SR-BI Receptor Localization

The SR-BI scavenger receptor is important for cholesterol uptake and Hepatitis C Virus (HCV) entry.  A recent paper used immunofluorescent staining to show correct receptor localization of SR-BI on the basolateral membrane of 3D InSight™ Liver Microtissues, similar to native liver.  The article gives further credence to the more organotypic nature of 3D liver microtissues, as 2D cultures did not mirror in vivo SR-BI localization.  Get the open access paper.

State-of-the-Art in 3D Microtissue Models: An Update

Just as a chain is only as strong as its weakest link, a Body-on-a-Chip system is only as predictive as the individual tissue components it connects.  This recent ALTEX report from the T4 (Trans-Atlantic Think Tank for Toxicology) takes a deeper dive into the pros and cons of various 3D tissue models including liver, brain, skin, and lung.  Read the full report

New Video:  Meet the Cell3iMager

If you are looking for a fast, easy way to scan and measure spheroid size and morphology, take 2 minutes to introduce yourself to the Cell3iMager.  This 3D optimized, label-free imager from Dainippon SCREEN is now available in North America and Europe exclusively through InSphero.  Watch the video.

Lit Picks:  Simon Says "Don't miss these papers!"

Dr. Simon Messner, InSphero's Senior Product Manager for Microtissues, has selected a couple of must-read reviews from the August issue of Nature Biotechnology.  Read up on 3D bioprinting and organs-on-chips in this edition of InSphero's Literature Picks.   



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