Hi <<First Name>>, Streamline your compound screening workflow with InSphero hepatotoxicity testing services!
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Hepatotoxicity Testing Services

Early compound de-risking and efficacy decisions require in vitro data with the highest possible biological relevance. Leverage our expertise in 3D microtissue technology and toxicology protocols to get consistent, highly relevant compound screening results with contract services utilizing 3D InSightâ„¢ Human Liver Microtissues.
 

Choose the service that best fits your needs:

14 Day

  • Assess chronic exposure to test chemicals via repeat dosing over 14 days
  • Capture acute and long-term effects on stress pathways and adaptive responses 
  • Increase predictive value over exposure time, with highest sensitivity toward hepatotoxicants 
Convenient testing runs start the first week of each month. Next runs start February 2 and March 1.

Cross-species

  • Choose up to three species for comparative hepatotoxicity testing:  Human, Rat, Dog, Pig, and Cynomolgus models available
  • Compare results of in vitro repeat dosing over 7 days with ATP endpoint in 3D primary hepatocytes for selected species
  • Prioritize compounds of interest before investing in costly animal studies

7 Day

  • Get rapid in vitro hepatotoxic characterization 
  • Compare responses to short-term doses of hepatotoxicants in different species to your existing in vivo data
  • Take advantage of this cost-effective tool to prioritize compounds using the most organotypic and relevant models available

Customized 

  • Work with us to develop a hepatotoxicity service tailored to your experimental design
  • Watch a webinar to learn about a custom service project designed for AstraZeneca toxicity testing and drug safety assessment
  • Contact our service team to discuss your proposal
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