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Upgrade Your Cell-Based Assays to 3D

With InSphero's microtissues being adopted by more and more labs worldwide our team has expanded to meet demand. We're now a close-knit, 15-strong team of dedicated scientists, engineers and specialists customer-focused staff, ready to give you every assistance you might need to upgrade your cell-based assays to 3D. Latest team members include Björn Niggemann, Head of Quality and Process Management, who will drive the ISO9001 certification program, and Prof. Bernhard Odermatt, Head of Histology, who will guarantee a very high level of histological expertise to InSphero's customers.

Our recent achievements do not remain unnoted. We are honored to be amongst the finalists in the ACES Award, Academic Enterprises Award Europe. The selection committee pointed out that "this is a novel three-dimensional cell-culture technology with very natural tissue characteristics".

We wish you an enjoyable reading and thank you for your interest in our newsletter and support.

Best regards

InSphero AG

Manuela Vujevic
Marketing Manager
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In this newsletter

New liver microtissues for chronic hepatotoxicity testing in 96-well format 

New scaffold-free EST assay 

Visit us at SOT, SBS and AACR 2011

Next Workshop : "Implementing Scaffold-Free 3D Cell-Culture Technologies", Zurich, May 6th, 2011

Workshops Feedback - Boston and San Francisco, Nov 2010

MMB 2011 – call for papers

New liver microtissues for chronic hepatotoxicity testing in 96-well format 
Coming soon : a range of scaffold-free liver microtissues from primary rat liver. Rat liver microtissues (rLiMT) consist of selected hepatocytes in co-culture with Kupffer macrophages, stellate cells or sinusoidal cells. These new models offer a striking resemblance to the cell composition of native liver : hepatocyte-specific functionality is maintained over three weeks (P450 protein basal levels and inducibility, albumin and urea secretion, polarized structure with bile canaliculi). Inflammation-mediated hepatotoxicity can easily be modeled using a Kupffer macrophage co-culture. Microtissues are delivered ready-to-use in 96-well plates, one tissue per well with consistent cell density and a size variation <10%. It's easy to evaluate and adopt rLiMT's since you can use the exact same endpoints and assay technology as with current 2D culture based assays.

If you would like to know more please contact us.

New scaffold-free EST assay
The Embryonic Stem Cell Test (EST) is a reliable alternative to toxicity testing in animals but using the classic hanging drop method for EB production is a time-consuming, labour-intensive procedure. These drawbacks are completely overcome with the EST Assay Kit from InSphero that enables fast, highly reproducible, automated or semi-automated production of mouse embryoid bodies (EB) in 96-well plate format, ready for use in embryotoxicity and teratogenicity assays. The EST Assay Kit is based on a precision-engineered disposable top-plate (patent pending) that eliminates the need for manual plate turning and picking of EBs. The system is compatible with standard multichannel pipetting equipment.

If you would like to know more please contact us.

Visit us at SOT, SBS and AACR 2011 
Visit the InSphero booth at these upcoming meetings and find out how assay-ready 3D microtissues could reduce costs and vastly improve the reliability of your screening data.

  • SOT 50th Annual Meeting and ToxExpo 2011, March 6th – 10th, Washington, D.C., USA
    Launch of our Rat Liver Microtissues (rLiMT), free tutorial session on "Drug Testing Using 3D Microtissues" on Wednesday, March 9 from 10:30 AM to 11:30 AM and poster presentation “An Organotypic Microliver Platform for High Throughput Drug Testing” by Dr. Simon Messner on Thursday, March 10 from 8:30 AM to 12:00 PM. Learn more here.
  • SBS 17th Annual Conference & Exhibition 2011, March 27th – 30th, Orlando, FL, USA
    Launch of the first automation-compatible kit for embryoid body formation for Embryonic Stem Cell Toxicity (EST) testing. We'll be presenting the full range of our ready-to-use microtissues for HTS and HCS using scaffold-free 3D cell culture models and hold a poster presentation and free tutorial session on "Drug Testing Using 3D Microtissues" on Tuesday, March 29 from 8:00 AM to 9:00 AM. More information here.

  • AACR 102nd Annual Meeting 2011, April 2nd – 6th, Orlando, FL, USA
    USA launch of cell-line-based 3D cancer microtissues, including co-culture models. Plus, InSphero will launch new evaluation tools including cDNA samples from our microtissue portfolio. More information here.

To arrange a meeting or a webinar please send us an E-mail.

Next Workshop : "Implementing Scaffold-Free 3D Cell-Culture Technologies", Zurich, May 6th, 2011
Attending an InSphero workshop is an excellent way to get fully updated with the latest information on 3D-cell-culture technologies for toxicological and efficacy studies. Our expert team, with their many years of combined experience, is in a unqiue position to provide you with information on different approaches to 3D culture and assays and the main issues affecting quality and costs in this segment of the industry today.
The next workshop will take place in Zurich, Switzerland, on May 6th, 2011. This will be a whole day event starting at 9:00am. 

We strongly advise you to pre-book now as the number of places is limited. Register here.

Workshops Feedback - Boston and San Francisco, Nov 2010
InSphero ran two half-day workshops, "Drug Testing Using 3D Microtissues", in Boston and San Francisco in November 2010. Participants gained valuable insights into the use of different 3D cell culture and microtissue culture technologies and applications in oncology and toxicology. In addition, examples of the successful application of skin microtissue models in validated processes were presented as well as high-content screening data. Our next workshop will take place in Zurich (May 2011) and in the USA in the fall (date and venue to be announced shortly). 

Interested in attending an InSphero workshop? Please let us know.

MMB 2011 – call for papers
InSphero is supporting MMB 2011 " The 6th International Conference on Microtechnologies in Medicine and Biology", Lucerne, Switzerland, May 4th-6th, 2011, see : conference website. If you would like to meet InSphero at this event please let us know in advance.

About InSphero

InSphero is the leading, award-winning supplier of assay-ready 3D microtissues for drug discovery and in vitro toxicology. We offer single and multicell microtissues off-the-shelf, 1 x microtissue per well in standard plate format, helping you to improve data-relevance and to reduce the overall cost of drug discovery. The company, headquartered in Zurich, Switzerland, has established a solid customer base with more than ten global pharmaceutical and cosmetics companies. InSphero, founded in 2009, is a spin-off company of the Swiss Federal Institute of Technology (ETH) Zurich and the University Zurich. Currently, InSphero employs 15 specialists and occupies 230 sqm of production, laboratory and office space at the Technopark in Zurich, Switzerland. InSphero was recognized for its scientific and commercial achievements with a number of awards, including the VentureKick award, Heuberger Entrepreneurial Award and CTIstartup certification.

Our mailing address is:
InSphero Inc.
74 Orion St
Brunswick, ME 04011-5031

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